Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy through regulation of gut microbiota and bile acid metabolism

2021 ◽  
Author(s):  
Ming-zhi Zhu ◽  
Fang Zhou ◽  
Jian Ouyang ◽  
Qi-ye Wang ◽  
Yi-long Li ◽  
...  
Keyword(s):  
Bile Acid ◽  
Synergistic Effect ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Low Doses ◽  
Combined Use

Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy. The synergistic effect may be attributed to regulation of gut microbiota and BA metabolism.

scholarly journals Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism

2019 ◽  
Vol 64 (1) ◽  
pp. 1900789 ◽  
Author(s):  
Yang Zhang ◽  
Gerd Bobe ◽  
Johana S. Revel ◽  
Richard R. Rodrigues ◽  
Thomas J. Sharpton ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Bile Acid ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism

scholarly journals Functional microbiomics: Evaluation of gut microbiota-bile acid metabolism interactions in health and disease

Methods ◽  
2018 ◽  
Vol 149 ◽  
pp. 49-58 ◽  
Author(s):  
Benjamin H. Mullish ◽  
Alexandros Pechlivanis ◽  
Grace F. Barker ◽  
Mark R. Thursz ◽  
Julian R. Marchesi ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Health And Disease

scholarly journals Gut Microbiota Dysbiosis Associated with Bile Acid Metabolism in Neonatal Cholestasis Disease

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Meng Li ◽  
Sixiang Liu ◽  
Mingying Wang ◽  
Hongwei Hu ◽  
Jianwen Yin ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Neonatal Cholestasis ◽  
Gut Microbiota Dysbiosis

The influence of rosuvastatin on the gastrointestinal microbiota and host gene expression profiles

2017 ◽  
Vol 312 (5) ◽  
pp. G488-G497 ◽  
Author(s):  
J. A. Nolan ◽  
P. Skuse ◽  
K. Govindarajan ◽  
E. Patterson ◽  
N. Konstantinidou ◽  
...  
Keyword(s):  
Gene Expression ◽  
Community Structure ◽  
Bile Acid ◽  
Microbial Community ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Bile Acid Metabolism ◽  
Gastrointestinal Microbiota

Statins are the most widely prescribed medications worldwide for the treatment of hypercholesterolemia. They inhibit the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-R), an enzyme involved in cholesterol synthesis in higher organisms and in isoprenoid biosynthesis in some bacteria. We hypothesized that statins may influence the microbial community in the gut through either direct inhibition or indirect mechanisms involving alterations to host responses. We therefore examined the impact of rosuvastatin (RSV) on the community structure of the murine gastrointestinal microbiota. RSV was orally administered to mice and the effects on the gut microbiota, host bile acid profiles, and markers of inflammation were analyzed. RSV significantly influenced the microbial community in both the cecum and feces, causing a significant decrease in α-diversity in the cecum and resulting in a reduction of several physiologically relevant bacterial groups. RSV treatment of mice significantly affected bile acid metabolism and impacted expression of inflammatory markers known to influence microbial community structure (including RegIIIγ and Camp) in the gut. This study suggests that a commonly used statin (RSV) leads to an altered gut microbial composition in normal mice with attendant impacts on local gene expression profiles, a finding that should prompt further studies to investigate the implications of statins for gut microbiota stability and health in humans. NEW & NOTEWORTHY This work demonstrates that rosuvastatin administration in mice affects the gastrointestinal microbiota, influences bile acid metabolism, and alters transcription of genes encoding factors involved in gut homeostasis and immunity in the gastrointestinal tract.

scholarly journals The Role of the Gut Microbiota in Bile Acid Metabolism

2017 ◽  
Vol 16 ◽  
pp. S21-S26 ◽  
Author(s):  
Oscar Ramírez-Pérez ◽  
Vania Cruz-Ramón ◽  
Paulina Chinchilla-López ◽  
Nahum Méndez-Sánchez
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism
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