Liver Fibrosis Associated with Potential Vinyl Chloride and Ethylene Dichloride Exposure from the Petrochemical Industry

2020 ◽  
Author(s):  
Tzu-Hsuen Yuan ◽  
Jun-Lin Chen ◽  
Ruei-Hao Shie ◽  
Yen-Po Yeh ◽  
Chang-Chuan Chan
Keyword(s):  
Liver Fibrosis ◽  
Vinyl Chloride ◽  
Petrochemical Industry ◽  
Ethylene Dichloride

Liver fibrosis associated with potential vinyl chloride and ethylene dichloride exposure from the petrochemical industry

2020 ◽  
Vol 739 ◽  
pp. 139920 ◽  
Author(s):  
Tzu-Hsuen Yuan ◽  
Jun-Lin Chen ◽  
Ruei-Hao Shie ◽  
Yen-Po Yeh ◽  
Yi-Hsuan Chen ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Vinyl Chloride ◽  
Petrochemical Industry ◽  
Ethylene Dichloride

Coke Produced in the Commercial Pyrolysis of Ethylene Dichloride into Vinyl Chloride

1996 ◽  
Vol 35 (10) ◽  
pp. 3803-3807 ◽  
Author(s):  
Isao Mochida ◽  
Tadanori Tsunawaki ◽  
Chiaki Sotowa ◽  
Yozo Korai ◽  
Kazuo Higuchi
Keyword(s):  
Vinyl Chloride ◽  
Ethylene Dichloride

Problems and Prospects of Production of Vinyl Chloride, and Its Toxicity (Review)

2018 ◽  
Vol 6 (5) ◽  
pp. 68-76
Author(s):  
Галина Бодиенкова ◽  
Galina Bodienkova
Keyword(s):  
Vinyl Chloride ◽  
Polyvinyl Chloride ◽  
Building Materials ◽  
The Body ◽  
Polymer Materials ◽  
Ethylene Dichloride ◽  
Technical Equipment ◽  
Toxic Substances ◽  
Nervous Systems ◽  
Labor Conditions

The paper gives an overview of the literature data reflecting the issue’s current state and prospects for vinyl chloride production in Russia and abroad. A brief analysis of topical questions on vinyl chloride toxicity and its influence on workers’ body functional systems have been presented. According to international experts’ estimation more than 2 million people are involved in vinyl chloride and polyvinylchloride production. Vinyl chloride is a feedstock for the production of polyvinyl chloride resin and various polymer materials based on it — finishing and building materials, packaging containers for food, pipes for household and drinking water supply, technical equipment, household items, artificial leather and goods based on it. Vinyl chloride consumption is growing every year. It has been included in the lists of the most dangerous and toxic substances. Experimental and clinical studies have shown its complex toxic effect on the body, characterized by damage to the central and peripheral nervous systems, liver, bone system, connective tissue, manifestation of carcinogenic, mutagenic, teratogenic effects. Main sources of industrial hazards remain vinyl chloride and ethylene dichloride — chemicals of 1 to 2 classes of danger, which in modern conditions, as a rule, do not exceed, or only slightly exceed hygienic standards. In accordance with this, cases of occupational intoxication are the rare ones (mainly when the production technology and safety precautions are violated), and are most often not clearly expressed. At the same time, workers’ labor conditions in vinyl chloride and polyvinyl chloride production facilities are classified as harmful, which is facilitated, in addition to a chemical factor, by unfavorable microclimatic conditions and production noise. In this connection, at a number of enterprises there is an increase in the number of diseases related to the circulatory and nervous systems, as well as mental disorders. At healthy and trained workers which are in contact with vinyl chloride, have been revealed changes in the immune system, characterized by imbalance of cytokines and violation of autoimmune regulation. In this regard, it is advisable to improve the methodology for assessing of occupational risk taking into account specific labor conditions, including highly informative indicators of early changes in the workers’ health status.

Effect of the CYP2E1 genotype on vinyl chloride monomer-induced liver fibrosis among polyvinyl chloride workers

Toxicology ◽  
2007 ◽  
Vol 239 (1-2) ◽  
pp. 34-44 ◽  
Author(s):  
Hui-I Hsieh ◽  
Pau-Chung Chen ◽  
Ruey-Hong Wong ◽  
Jung-Der Wang ◽  
Pei-Ming Yang ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Vinyl Chloride ◽  
Polyvinyl Chloride ◽  
Vinyl Chloride Monomer
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