scholarly journals Trends in oral cavity cancer incidence, mortality, survival and treatment in the Netherlands

2016 ◽  
Vol 139 (3) ◽  
pp. 574-583 ◽  
Author(s):  
Boukje A.C. van Dijk ◽  
Marieke T. Brands ◽  
Sandra M.E. Geurts ◽  
Matthias A.W. Merkx ◽  
Jan L.N. Roodenburg
Keyword(s):  
The Netherlands ◽  
Oral Cavity ◽  
Cancer Incidence ◽  
Oral Cavity Cancer

scholarly journals Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Gijs Geleijnse ◽  
RuRu Chun-Ju Chiang ◽  
Melle Sieswerda ◽  
Melinda Schuurman ◽  
K. C. Lee ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
The Netherlands ◽  
Oral Cavity ◽  
Cancer Registry ◽  
Hospital Volume ◽  
Oral Cavity Cancer ◽  
Lower Grade ◽  
Risk Of Death ◽  
Patient Level ◽  
Netherlands Cancer Registry

AbstractThe difference in incidence of oral cavity cancer (OCC) between Taiwan and the Netherlands is striking. Different risk factors and treatment expertise may result in survival differences between the two countries. However due to regulatory restrictions, patient-level analyses of combined data from the Netherlands and Taiwan are infeasible. We implemented a software infrastructure for federated analyses on data from multiple organisations. We included 41,633‬ patients with single-tumour OCC between 2004 and 2016, undergoing surgery, from the Taiwan Cancer Registry and Netherlands Cancer Registry. Federated Cox Proportional Hazard was used to analyse associations between patient and tumour characteristics, country, treatment and hospital volume with survival. Five factors showed differential effects on survival of OCC patients in the Netherlands and Taiwan: age at diagnosis, stage, grade, treatment and hospital volume. The risk of death for OCC patients younger than 60 years, with advanced stage, higher grade or receiving adjuvant therapy after surgery was lower in the Netherlands than in Taiwan; but patients older than 70 years, with early stage, lower grade and receiving surgery alone in the Netherlands were at higher risk of death than those in Taiwan. The mortality risk of OCC in Taiwanese patients treated in hospitals with higher hospital volume (≥ 50 surgeries per year) was lower than in Dutch patients. We conducted analyses without exchanging patient-level information, overcoming barriers for sharing privacy sensitive information. The outcomes of patients treated in the Netherlands and Taiwan were slightly different after controlling for other prognostic factors.

scholarly journals Oral cavity cancer incidence and mortality in China, 2010

2015 ◽  
Vol 11 (6) ◽  
pp. 149 ◽  
Author(s):  
Qing-Min Xia ◽  
Chuan-Ming Zheng ◽  
Ming-Hua Ge ◽  
Shuang-Shuang Zhang ◽  
Zhuo Tan ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Cancer Incidence ◽  
Oral Cavity Cancer ◽  
Incidence And Mortality

scholarly journals Trends in oropharyngeal and oral cavity cancer incidence of human papillomavirus (HPV)-related and HPV-unrelated sites in a multicultural population

Cancer ◽  
2010 ◽  
pp. NA-NA ◽  
Author(s):  
Ajit Auluck ◽  
Greg Hislop ◽  
Chris Bajdik ◽  
Catherine Poh ◽  
Lewei Zhang ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Oral Cavity ◽  
Cancer Incidence ◽  
Oral Cavity Cancer

Oral cavity cancer incidence rates in Osaka, Japan between 2000 and 2014

Oral Oncology ◽  
2020 ◽  
Vol 105 ◽  
pp. 104653 ◽  
Author(s):  
Shihoko Koyama ◽  
Takahiro Tabuchi ◽  
Sumiyo Okawa ◽  
Toshitaka Morishima ◽  
Shunsuke Ishimoto ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Cancer Incidence ◽  
Oral Cavity Cancer ◽  
Incidence Rates ◽  
Cancer Incidence Rates

Preoperative prognostic nutritional index predicts prognosis of patients with oral cavity cancer

Oral Diseases ◽  
2021 ◽  
Author(s):  
Ku‐Hao Fang ◽  
Sheng‐Wei Chang ◽  
Yi‐Chan Lee ◽  
Ethan I Huang ◽  
Chia‐Hsuan Lai ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Oral Cavity Cancer ◽  
Prognostic Nutritional Index ◽  
Nutritional Index

scholarly journals Translation of c-Met Targeted Image-Guided Surgery Solutions in Oral Cavity Cancer—Initial Proof of Concept Data

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2674
Author(s):  
Tessa Buckle ◽  
Maarten van Alphen ◽  
Matthias N. van Oosterom ◽  
Florian van Beurden ◽  
Nina Heimburger ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Oral Cavity Cancer ◽  
Ex Vivo ◽  
Intermediate Step ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Tumor Identification ◽  
Imaging Results ◽  
Pathological Evaluation ◽  
Fluorescence Camera

Intraoperative tumor identification (extension/margins/metastases) via receptor-specific targeting is one of the ultimate promises of fluorescence-guided surgery. The translation of fluorescent tracers that enable tumor visualization forms a critical component in the realization of this approach. Ex vivo assessment of surgical specimens after topical tracer application could help provide an intermediate step between preclinical evaluation and first-in-human trials. Here, the suitability of the c-Met receptor as a potential surgical target in oral cavity cancer was explored via topical ex vivo application of the fluorescent tracer EMI-137. Freshly excised tumor specimens obtained from ten patients with squamous cell carcinoma of the tongue were incubated with EMI-137 and imaged with a clinical-grade Cy5 prototype fluorescence camera. In-house developed image processing software allowed video-rate assessment of the tumor-to-background ratio (TBR). Fluorescence imaging results were related to standard pathological evaluation and c-MET immunohistochemistry. After incubation with EMI-137, 9/10 tumors were fluorescently illuminated. Immunohistochemistry revealed c-Met expression in all ten specimens. Non-visualization could be linked to a more deeply situated lesion. Tumor assessment was improved via video representation of the TBR (median TBR: 2.5 (range 1.8–3.1)). Ex vivo evaluation of tumor specimens suggests that c-Met is a possible candidate for fluorescence-guided surgery in oral cavity cancer.

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