Decellularized Porcine Cornea-Based Hydrogels for Regeneration of Corneal Epithelium and Stroma

2020 ◽  
Author(s):  
Fuyan Wang ◽  
Weiyun Shi ◽  
Hua Li ◽  
Long Zhao ◽  
Dapeng Sun ◽  
...  
Keyword(s):  
Corneal Epithelium ◽  
Porcine Cornea

scholarly journals Sleep Deprivation Induces Dry Eye Through Inhibition of PPARα Expression in Corneal Epithelium

2018 ◽  
Vol 59 (13) ◽  
pp. 5494 ◽  
Author(s):  
Liying Tang ◽  
Xue Wang ◽  
Jieli Wu ◽  
San Ming Li ◽  
Zhaoqiang Zhang ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Dry Eye ◽  
Corneal Epithelium

scholarly journals Kynurenic Acid Accelerates Healing of Corneal Epithelium In Vitro and In Vivo

2021 ◽  
Vol 14 (8) ◽  
pp. 753
Author(s):  
Anna Matysik-Woźniak ◽  
Waldemar A. Turski ◽  
Monika Turska ◽  
Roman Paduch ◽  
Mirosław Łańcut ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Corneal Epithelium ◽  
Kynurenic Acid ◽  
Pharmaceutical Products ◽  
Corneal Epithelial Cell ◽  
Eye Drops ◽  
Conjunctival Epithelium ◽  
Corneal Erosion

Kynurenic acid (KYNA) is an endogenous compound with a multidirectional effect. It possesses antiapoptotic, anti-inflammatory, and antioxidative properties that may be beneficial in the treatment of corneal injuries. Moreover, KYNA has been used successfully to improve the healing outcome of skin wounds. The aim of the present study is to evaluate the effects of KYNA on corneal and conjunctival cells in vitro and the re-epithelization of corneal erosion in rabbits in vivo. Normal human corneal epithelial cell (10.014 pRSV-T) and conjunctival epithelial cell (HC0597) lines were used. Cellular metabolism, cell viability, transwell migration, and the secretion of IL-1β, IL-6, and IL-10 were determined. In rabbits, after corneal de-epithelization, eye drops containing 0.002% and 1% KYNA were applied five times a day until full recovery. KYNA decreased metabolism but did not affect the proliferation of the corneal epithelium. It decreased both the metabolism and proliferation of conjunctival epithelium. KYNA enhanced the migration of corneal but not conjunctival epithelial cells. KYNA reduced the secretion of IL-1β and IL-6 from the corneal epithelium, leaving IL-10 secretion unaffected. The release of all studied cytokines from the conjunctival epithelium exposed to KYNA was unchanged. KYNA at higher concentration accelerated the healing of the corneal epithelium. These favorable properties of KYNA suggest that KYNA containing topical pharmaceutical products can be used in the treatment of ocular surface diseases.

The Effects of Fibronectin on the Adherence of Bacteria to Corneal Epithelium

Cornea ◽  
1991 ◽  
Vol 10 (5) ◽  
pp. 387-389 ◽  
Author(s):  
Alice Y. Matoba ◽  
Richard J. Hamill ◽  
Michael S. Osato
Keyword(s):  
Corneal Epithelium
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