Exploring Characteristic Alteration of the White Matter Functional Networks at Rest in Children with Attention-Deficit/Hyperactivity Disorder

2019 ◽  
Author(s):  
Xuan Bu ◽  
Kaili Liang ◽  
Qingxia Lin ◽  
Hailong Li ◽  
Yingxue Gao ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
White Matter ◽  
Attention Deficit ◽  
Functional Networks ◽  
Hyperactivity Disorder

scholarly journals Exploring white matter functional networks in children with attention-deficit/hyperactivity disorder

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Xuan Bu ◽  
Kaili Liang ◽  
Qingxia Lin ◽  
Yingxue Gao ◽  
Andan Qian ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
White Matter ◽  
Attention Deficit ◽  
Default Mode Network ◽  
Functional Networks ◽  
Attention Network ◽  
Attention Networks ◽  
Default Mode ◽  
Hyperactivity Disorder ◽  
Drug Naïve

Abstract Attention-deficit/hyperactivity disorder has been identified to involve the impairment of large-scale functional networks within grey matter, and recent studies have suggested that white matter, which also encodes neural activity, can manifest intrinsic functional organization similar to that of grey matter. However, the alterations in white matter functional networks in attention-deficit/hyperactivity disorder remain unknown. We recruited a total of 99 children, including 66 drug-naive patients and 33 typically developing controls aged from 6 to 14, to characterize the alterations in functional networks within white matter in drug-naive children with attention-deficit/hyperactivity disorder. Using clustering analysis, resting-state functional MRI data in the white matter were parsed into different networks. Intrinsic activity within each network and connectivity between networks and the associations between network activity strength and clinical symptoms were assessed. We identified eight distinct white matter functional networks: the default mode network, the somatomotor network, the dorsal attention network, the ventral attention network, the visual network, the deep frontoparietal network, the deep frontal network and the inferior corticospinal-posterior cerebellum network. The default mode, somatomotor, dorsal attention and ventral attention networks showed lower spontaneous neural activity in patients. In particular, the default mode network and the somatomotor network largely showed higher connectivity with other networks, which correlated with more severe hyperactive behaviour, while the dorsal and ventral attention networks mainly had lower connectivity with other networks, which correlated with poor attention performance. In conclusion, there are two distinct patterns of white matter functional networks in children with attention-deficit/hyperactivity disorder, with one being the hyperactivity-related hot networks including default mode network and somatomotor network and the other being inattention-related cold networks including dorsal attention and ventral attention network. These results extended upon our understanding of brain functional networks in attention-deficit/hyperactivity disorder from the perspective of white matter dysfunction.

scholarly journals COMT genotype affects brain white matter pathways in attention-deficit/hyperactivity disorder

2014 ◽  
Vol 36 (1) ◽  
pp. 367-377 ◽  
Author(s):  
Soon-Beom Hong ◽  
Andrew Zalesky ◽  
Subin Park ◽  
Young-Hui Yang ◽  
Min-Hyeon Park ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
White Matter ◽  
Attention Deficit ◽  
Comt Genotype ◽  
Hyperactivity Disorder ◽  
Brain White Matter

Abnormal asymmetry in frontostriatal white matter in children with attention deficit hyperactivity disorder

2015 ◽  
Vol 10 (4) ◽  
pp. 1080-1089 ◽  
Author(s):  
Timothy J. Silk ◽  
Veronika Vilgis ◽  
Chris Adamson ◽  
Jian Chen ◽  
Lisa Smit ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
White Matter ◽  
Attention Deficit ◽  
Hyperactivity Disorder

scholarly journals Comprehensive Examination of Frontal Regions in Boys and Girls with Attention-Deficit/Hyperactivity Disorder

2011 ◽  
Vol 17 (6) ◽  
pp. 1047-1057 ◽  
Author(s):  
E. Mark Mahone ◽  
Marin E. Ranta ◽  
Deana Crocetti ◽  
Jessica O'Brien ◽  
Walter E. Kaufmann ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
White Matter ◽  
Frontal Lobe ◽  
Gray Matter ◽  
Attention Deficit ◽  
Hyperactivity Disorder ◽  
Matter Volume ◽  
Medial Pfc ◽  
Gray Matter Volumes ◽  
Girls With Adhd

AbstractThe current study examined regional frontal lobe volumes based on functionally relevant subdivisions in contemporaneously recruited samples of boys and girls with and without attention-deficit/hyperactivity disorder (ADHD). Forty-four boys (21 ADHD, 23 control) and 42 girls (21 ADHD, 21 control), ages 8–13 years, participated. Sulcal–gyral landmarks were used to manually delimit functionally relevant regions within the frontal lobe: primary motor cortex, anterior cingulate, deep white matter, premotor regions [supplementary motor complex (SMC), frontal eye field, lateral premotor cortex (LPM)], and prefrontal cortex (PFC) regions [medial PFC, dorsolateral PFC (DLPFC), inferior PFC, lateral orbitofrontal cortex (OFC), and medial OFC]. Compared to sex-matched controls, boys and girls with ADHD showed reduced volumes (gray and white matter) in the left SMC. Conversely, girls (but not boys) with ADHD showed reduced gray matter volume in left LPM; while boys (but not girls) with ADHD showed reduced white matter volume in left medial PFC. Reduced left SMC gray matter volumes predicted increased go/no–go commission rate in children with ADHD. Reduced left LPM gray matter volumes predicted increased go/no–go variability, but only among girls with ADHD. Results highlight different patterns of anomalous frontal lobe development among boys and girls with ADHD beyond that detected by measuring whole lobar volumes. (JINS, 2011, 17, 1047–1057)

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