scholarly journals Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex

2019 ◽  
Author(s):  
Bor-Shuen Wang ◽  
Maria Sol Bernardez Sarria ◽  
Miao He ◽  
Michael C. Crair ◽  
Z. Josh Huang
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Chandelier Cell ◽  
Activity Dependent

scholarly journals Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex

Neuron ◽  
2020 ◽  
Author(s):  
Bor-Shuen Wang ◽  
Maria Sol Bernardez Sarria ◽  
Xu An ◽  
Miao He ◽  
Nazia M. Alam ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Chandelier Cell ◽  
Activity Dependent

scholarly journals Retinal and callosal activity-dependent chandelier cell elimination shapes binocularity in primary visual cortex

2019 ◽  
Author(s):  
Bor-Shuen Wang ◽  
Maria Sol Bernardez Sarria ◽  
Miao He ◽  
Michael C Crair ◽  
Z. Josh Huang
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Binocular Vision ◽  
Activity Patterns ◽  
Inhibitory Neuron ◽  
Chandelier Cell ◽  
Eye Opening ◽  
Chandelier Cells ◽  
Activity Dependent ◽  
Callosal Pathway

AbstractIn mammalian primary visual cortex (V1), integration of the left and right visual scene into a binocular percept derives from convergent ipsi- and contralateral geniculocortical inputs and trans-callosal projections between the two hemispheres. However, the underlying developmental mechanisms remain incompletely understood. Using genetic methods in mice we found that during the days before eye-opening, retinal and callosal activity drives massive apoptosis of GABAergic chandelier cells (ChCs) in the binocular region of V1. Blockade of ChC elimination resulted in a contralateral-dominated V1 and deficient binocular vision. As activity patterns within and between retinas prior to vision convey organization of the visual field, their regulation of ChC density through the trans-callosal pathway may prime a nascent binocular territory for subsequent experience-driven tuning during the post-vision critical period.One Sentence SummaryPrior to eye opening the developing retina primes the visual cortex for binocular vision by adjusting the density of a cortical inhibitory neuron type.

scholarly journals Activity-dependent regulation of MHC class I expression in the developing primary visual cortex of the common marmoset monkey

2011 ◽  
Vol 7 (1) ◽  
pp. 1 ◽  
Author(s):  
Adema Ribic ◽  
Gabriele Flügge ◽  
Christina Schlumbohm ◽  
Kerstin Mätz-Rensing ◽  
Lutz Walter ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Mhc Class I ◽  
Primary Visual Cortex ◽  
Common Marmoset ◽  
Class I ◽  
Marmoset Monkey ◽  
The Common ◽  
Activity Dependent
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