The Dephosphorylation of MCM2 at Serine27 Site Attenuates Ovarian Cancer Metastasis via Regulating Wnt/β-Catenin Signaling Pathway

2019 ◽  
Author(s):  
Huimin Li ◽  
Xinming Chi ◽  
Liying Chen ◽  
Xiaoyu Qi ◽  
Yuxin Bai ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Signaling Pathway ◽  
Cancer Metastasis

scholarly journals CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway

2015 ◽  
Vol 55 (11) ◽  
pp. 1688-1699 ◽  
Author(s):  
Qi Wang ◽  
Yong Tang ◽  
Hongjing Yu ◽  
Qiaoyun Yin ◽  
Mengdi Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Signaling Pathway ◽  
Tumor Cells ◽  
Cancer Metastasis ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

scholarly journals β-hCG promotes epithelial ovarian cancer metastasis through ERK/MMP2 signaling pathway

Cell Cycle ◽  
2018 ◽  
Vol 18 (1) ◽  
pp. 46-59 ◽  
Author(s):  
Weimin Wu ◽  
Hao Gao ◽  
Xiaofeng Li ◽  
Shumin Peng ◽  
Jing Yu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Signaling Pathway ◽  
Cancer Metastasis ◽  
Β Hcg

scholarly journals MGAT3-mediated glycosylation of tetraspanin CD82 at asparagine 157 suppresses ovarian cancer metastasis by inhibiting the integrin signaling pathway

Theranostics ◽  
2020 ◽  
Vol 10 (14) ◽  
pp. 6467-6482 ◽  
Author(s):  
Jun Li ◽  
Jiawen Xu ◽  
Luhan Li ◽  
Alessandro Ianni ◽  
Poonam Kumari ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Signaling Pathway ◽  
Cancer Metastasis ◽  
Integrin Signaling

scholarly journals Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 76266-76278 ◽  
Author(s):  
Haiying Niu ◽  
Wei Zhou ◽  
Yingxi Xu ◽  
Zhiqi Yin ◽  
Wenzhi Shen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Signaling Pathway ◽  
Cancer Metastasis

Exploring the Potential of Capsaicin Against Cancer Metastasis Based on TGF-β Signaling Modulation Through Module-based Network Pharmacology Approach

2020 ◽  
Vol 17 (5) ◽  
pp. 647-660 ◽  
Author(s):  
Shivananda Kandagalla ◽  
Sharath Belenahalli Shekarappa ◽  
Gollapalli Pavan ◽  
Umme Hani ◽  
Manjunatha Hanumanthappa
Keyword(s):  
Amino Acid ◽  
Amino Acid Composition ◽  
Signaling Pathway ◽  
Acid Composition ◽  
Protein Interaction ◽  
Cancer Metastasis ◽  
Enrichment Analysis ◽  
Functional Enrichment ◽  
Mode Analysis ◽  
Network Pharmacology

Background: Capsaicin is an active alkaloid /principal component of red pepper responsible for the pungency of chili pepper. Capsaicin by changing the intracellular redox homeostasis regulate a variety of signaling pathways ultimately producing a divergent cellular outcome. Several reports showed the potential of capsaicin against cancer metastasis, however unexplored molecular mechanism is still an active part of the research. Several growth factors have a critical role during cancer metastasis among them TGF- β signaling play a vital role. Methods: The present study aimed at analyzing capsaicin modulation of TGF-β signaling using network pharmacology approach. The chemical and protein interaction data of capsaicin was curated and abstracted using STITCH4.0, PubChem and ChEMBL database. Further, the compiled data set was subjected to the pathway and functional enrichment analysis using Protein Analysis THrough Evolutionary Relationship (PANTHER) and, Database for Annotation, Visualization, and Integrated Discovery (DAVID) database. Meanwhile, the pattern of amino acid composition across the capsaicin targets was analyzed using the EMBOSS Pepstat tool. Capsaicin targets involved in TGF- β were identified and their Protein-Protein Interaction (PPI) network constructed using STRING v10 and Cytoscape (v 3.2.1). From the above-constructed network, the clusters were mined using the MCODE clustering algorithm and finally binding affinity of capsaicin with its targets involved in TGF-β signaling pathway was analyzed using Autodock Vina. Results: The analysis explored capsaicin targets and, their associated functional and pathway annotations. Besides, the analysis also provides a detailed distinct pattern of amino acid composition across the capsaicin targets. The capsaicin targets described as MAPK14, JUN, SMAD3, MAPK3, MAPK1 and MYC involved in TGF-β signaling pathway through pathway enrichment analysis. The binding mode analysis of capsaicin with its targets has shown high affinity with MAPK3, MAPK1, JUN and MYC. Conclusion: The study explores the potential of capsaicin as a potent modulator of TGF-β signaling pathway during cancer metastasis and proposes new methodology and mechanism of action of capsaicin against TGF- β signaling pathway.

CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway

Life Sciences ◽  
2021 ◽  
Vol 268 ◽  
pp. 118996
Author(s):  
Jiangtao Yu ◽  
Xiaoli Hu ◽  
Xiuxiu Chen ◽  
Qiangyong Zhou ◽  
Qi Jiang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Ovarian Cancer Cells ◽  
Biological Functions ◽  
Akt Signaling Pathway

scholarly journals Entelon® (Vitis vinifera Seed Extract) Prevents Cancer Metastasis via the Downregulation of Interleukin-1 Alpha in Triple-Negative Breast Cancer Cells

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3644
Author(s):  
Daeun You ◽  
Yisun Jeong ◽  
Sun Young Yoon ◽  
Sung A Kim ◽  
Eunji Lo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signaling Pathway ◽  
Lung Metastasis ◽  
Triple Negative Breast Cancer ◽  
Cancer Metastasis ◽  
Triple Negative ◽  
Interleukin 1 ◽  
Metastatic Potential ◽  
Cancer Cell Proliferation ◽  
Dependent Pathway

Interleukin-1 (IL1) is a proinflammatory cytokine and promotes cancer cell proliferation and invasiveness in a diversity of cancers, such as breast and colon cancer. Here, we focused on the pharmacological effect of Entelon® (ETL) on the tumorigenesis of triple-negative breast cancer (TNBC) cells by IL1-alpha (IL1A). IL1A enhanced the cell growth and invasiveness of TNBC cells. We observed that abnormal IL1A induction is related with the poor prognosis of TNBC patients. IL1A also increased a variety of chemokines such as CCL2 and IL8. Interestingly, IL1A expression was reduced by the ETL treatment. Here, we found that ETL significantly decreased the MEK/ERK signaling pathway in TNBC cells. IL1A expression was reduced by UO126. Lastly, we studied the effect of ETL on the metastatic potential of TNBC cells. Our results showed that ETL significantly reduced the lung metastasis of TNBC cells. Our results showed that IL1A expression was regulated by the MEK/ERK- and PI3K/AKT-dependent pathway. Taken together, ETL inhibited the MEK/ERK and PI3K/AKT signaling pathway and suppressing the lung metastasis of TNBC cells through downregulation of IL1A. Therefore, we propose the possibility of ETL as an effective adjuvant for treating TNBC.

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