Monoamine Oxidase B Predicts Poor Prognosis in Colorectal Cancer Patients, and Its Expression Is Significantly Associated with Epithelial to Mesenchymal Transition

2019 ◽  
Author(s):  
Yi-Chieh Yang ◽  
Tsung-Ching Lai ◽  
Chia-Yi Su ◽  
Yi-Hua Jan ◽  
Ming-Hsien Chien ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Monoamine Oxidase ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Epithelial To Mesenchymal Transition ◽  
Monoamine Oxidase B ◽  
Mesenchymal Transition ◽  
Colorectal Cancer Patients

scholarly journals Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients

2021 ◽  
Vol 22 (9) ◽  
pp. 5019
Author(s):  
Helena Oliveres ◽  
David Pesántez ◽  
Joan Maurel
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Tyrosine Kinases ◽  
Epithelial To Mesenchymal Transition ◽  
Acquired Resistance ◽  
Post Translational Modification ◽  
Mesenchymal Transition ◽  
Igf1r Signaling ◽  
Colorectal Cancer Patients

Insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation. Upregulation of the IGF1R pathway constitutes a common paradigm shared with other receptor tyrosine kinases such as EGFR, HER2, and MET in different cancer types, including colon cancer. The main IGF1R signaling pathways are PI3K-AKT and MAPK-MEK. However, different processes, such as post-translational modification (SUMOylation), epithelial-to-mesenchymal transition (EMT), and microenvironment complexity, can also contribute to intrinsic and acquired resistance. Here, we discuss new strategies for adequate drug development in metastatic colorectal cancer patients.

scholarly journals KRAS and PIK3CA bi-mutations predict a poor prognosis in colorectal cancer patients: A single-site report

2020 ◽  
Vol 13 (12) ◽  
pp. 100874
Author(s):  
Qianxin Luo ◽  
Dianke Chen ◽  
Xinjuan Fan ◽  
Xinhui Fu ◽  
Tenghui Ma ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Single Site ◽  
Colorectal Cancer Patients

scholarly journals Monoamine Oxidase B Expression Correlates with a Poor Prognosis in Colorectal Cancer Patients and Is Significantly Associated with Epithelial-to-Mesenchymal Transition-Related Gene Signatures

2020 ◽  
Vol 21 (8) ◽  
pp. 2813 ◽  
Author(s):  
Yi-Chieh Yang ◽  
Ming-Hsien Chien ◽  
Tsung-Ching Lai ◽  
Chia-Yi Su ◽  
Yi-Hua Jan ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Epithelial To Mesenchymal Transition ◽  
Disease Free Survival ◽  
In Silico Analysis ◽  
Tissue Microarrays ◽  
Disease Stage ◽  
Clinicopathological Parameters ◽  
Gene Expressions ◽  
Mesenchymal Transition ◽  
Colorectal Cancer Patients

Monoamine oxidases (MAOs) including MAOA and MAOB are enzymes located on the outer membranes of mitochondria, which are responsible for catalyzing monoamine oxidation. Recently, increased level of MAOs were shown in several cancer types. However, possible roles of MAOs have not yet been elucidated in the progression and prognosis of colorectal carcinoma (CRC). We therefore analyzed the importance of MAOs in CRC by an in silico analysis and tissue microarrays. Several independent cohorts indicated that high expression of MAOB, but not MAOA, was correlated with a worse disease stage and poorer survival. In total, 203 colorectal adenocarcinoma cases underwent immunohistochemical staining of MAOs, and associations with clinicopathological parameters and patient outcomes were evaluated. We found that MAOB is highly expressed in CRC tissues compared to normal colorectal tissues, and its expression was significantly correlated with a higher recurrence rate and a poor prognosis. Moreover, according to the univariate and multivariate analyses, we found that MAOB could be an independent prognostic factor for overall survival and disease-free survival, and its prognostic value was better than T and N stage. Furthermore, significant positive and negative correlations of MAOB with mesenchymal-type and epithelial-type gene expressions were observed in CRC tissues. According to the highlighted characteristics of MAOB in CRC, MAOB can be used as a novel indicator to predict the progression and prognosis of CRC patients.

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