scholarly journals MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients

2014 ◽  
Vol 110 (6) ◽  
pp. 1614-1621 ◽  
Author(s):  
M Pichler ◽  
A L Ress ◽  
E Winter ◽  
V Stiegelbauer ◽  
M Karbiener ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Cancer Patients ◽  
Epithelial To Mesenchymal Transition ◽  
Related Gene ◽  
Mesenchymal Transition ◽  
Colorectal Cancer Patients

scholarly journals Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients

2021 ◽  
Vol 22 (9) ◽  
pp. 5019
Author(s):  
Helena Oliveres ◽  
David Pesántez ◽  
Joan Maurel
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Tyrosine Kinases ◽  
Epithelial To Mesenchymal Transition ◽  
Acquired Resistance ◽  
Post Translational Modification ◽  
Mesenchymal Transition ◽  
Igf1r Signaling ◽  
Colorectal Cancer Patients

Insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation. Upregulation of the IGF1R pathway constitutes a common paradigm shared with other receptor tyrosine kinases such as EGFR, HER2, and MET in different cancer types, including colon cancer. The main IGF1R signaling pathways are PI3K-AKT and MAPK-MEK. However, different processes, such as post-translational modification (SUMOylation), epithelial-to-mesenchymal transition (EMT), and microenvironment complexity, can also contribute to intrinsic and acquired resistance. Here, we discuss new strategies for adequate drug development in metastatic colorectal cancer patients.

Prognostic value of tumor progression-related gene expression in colorectal cancer patients

2012 ◽  
Vol 138 (10) ◽  
pp. 1631-1640 ◽  
Author(s):  
Miriam E. Uhlmann ◽  
Milka Georgieva ◽  
Martin Sill ◽  
Ulrich Linnemann ◽  
Martin R. Berger
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Tumor Progression ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Related Gene ◽  
Colorectal Cancer Patients

scholarly journals Evaluation of ST13 gene expression in colorectal cancer patients

2005 ◽  
Vol 6 (12) ◽  
pp. 1170-1175 ◽  
Author(s):  
Qing-hua Dong ◽  
Shu Zheng ◽  
Yue Hu ◽  
Gong-xing Chen ◽  
Jia-yi Ding
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Cancer Patients ◽  
Colorectal Cancer Patients

scholarly journals The Influence of Tumor Microenvironment on ATG4D Gene Expression in Colorectal Cancer Patients

2018 ◽  
Vol 35 (12) ◽  
Author(s):  
Justyna Gil ◽  
David Ramsey ◽  
Pawel Pawlowski ◽  
Elzbieta Szmida ◽  
Przemyslaw Leszczynski ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Tumor Microenvironment ◽  
Cancer Patients ◽  
Colorectal Cancer Patients

Abstract 478: Investigating prognostic value of proinflammatory M1 gene expression in colorectal cancer patients

2019 ◽  
Author(s):  
Pankaj Ahluwalia ◽  
Chance Bloomer ◽  
Chetan Pundkar ◽  
Kimya Jones ◽  
Ashis Mondal ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Colorectal Cancer Patients
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