Risk Factor Analysis of Severe Cerebral White Matter Hyperintensities in Type 2 Diabetes Patients: A Retrospective Single-Center Observational Study

2019 ◽  
Author(s):  
Jiayan Wu ◽  
Yunxiao Dou ◽  
Lu Liu ◽  
You Lu ◽  
Yanxin Zhao ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Factor Analysis ◽  
Risk Factor ◽  
White Matter ◽  
Observational Study ◽  
White Matter Hyperintensities ◽  
Cerebral White Matter ◽  
Single Center ◽  
Single Center Observational Study

scholarly journals Arterial stiffness and progression of cerebral white matter hyperintensities in patients with type 2 diabetes and matched controls: a 5-year cohort study

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Kristian L. Funck ◽  
Esben Laugesen ◽  
Pernille Høyem ◽  
Brian Stausbøl-Grøn ◽  
Won Y. Kim ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
White Matter ◽  
Arterial Stiffness ◽  
White Matter Hyperintensities ◽  
Cerebrovascular Diseases ◽  
Study Data ◽  
Cerebral White Matter ◽  
Intracranial Volume

Abstract Background Stroke is a serious complication in patients with type 2 diabetes (T2DM). Arterial stiffness may improve stroke prediction. We investigated the association between carotid-femoral pulse wave velocity [PWV] and the progression of cerebral white matter hyperintensities (WMH), a marker of stroke risk, in patients with T2DM and controls. Methods In a 5-year cohort study, data from 45 patients and 59 non-diabetic controls were available for analysis. At baseline, participants had a mean (± SD) age of 59  ±  10 years and patients had a median (range) diabetes duration of 1.8 (0.8–3.2) years. PWV was obtained by tonometry and WMH volume by an automated segmentation algorithm based on cerebral T2-FLAIR and T1 MRI (corrected by intracranial volume, cWMH). High PWV was defined above 8.94 m/s (corresponding to the reference of high PWV above 10 m/s using the standardized path length method). Results Patients with T2DM had a higher PWV than controls (8.8  ±  2.2 vs. 7.9  ±  1.4 m/s, p  <  0.01). WMH progression were similar in the two groups (p  =  0.5). One m/s increase in baseline PWV was associated with a 16% [95% CI 1–32%], p  <  0.05) increase in cWMH volume at 5 years follow-up after adjustment for age, sex, diabetes, pulse pressure and smoking. High PWV was associated with cWMH progression in the combined cohort (p  <  0.05). We found no interaction between diabetes and PWV on cWMH progression. Conclusions PWV is associated with cWMH progression in patients with type 2 diabetes and non-diabetic controls. Our results indicate that arterial stiffness may be involved early in the pathophysiology leading to cerebrovascular diseases.

scholarly journals Risk factor analysis of cerebral white matter hyperintensities in children with sickle cell disease

2015 ◽  
Vol 172 (2) ◽  
pp. 274-284 ◽  
Author(s):  
Veronica van der Land ◽  
Henri J. M. M. Mutsaerts ◽  
Marc Engelen ◽  
Harriët Heijboer ◽  
Mark Roest ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Risk Factor ◽  
White Matter ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
White Matter Hyperintensities ◽  
Risk Factor Analysis ◽  
Cerebral White Matter ◽  
Cell Disease

scholarly journals Disruption of the Cerebral White Matter Network Is Related to Slowing of Information Processing Speed in Patients With Type 2 Diabetes

Diabetes ◽  
2013 ◽  
Vol 62 (6) ◽  
pp. 2112-2115 ◽  
Author(s):  
Y. D. Reijmer ◽  
A. Leemans ◽  
M. Brundel ◽  
L. J. Kappelle ◽  
G. J. Biessels ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Information Processing ◽  
White Matter ◽  
Processing Speed ◽  
Cerebral White Matter ◽  
Information Processing Speed

scholarly journals Carotid-Femoral Pulse Wave Velocity Is Associated With Cerebral White Matter Lesions in Type 2 Diabetes

Diabetes Care ◽  
2012 ◽  
Vol 36 (3) ◽  
pp. 722-728 ◽  
Author(s):  
E. Laugesen ◽  
P. Hoyem ◽  
B. Stausbol-Gron ◽  
A. Mikkelsen ◽  
S. Thrysoe ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
White Matter ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Cerebral White Matter Lesions

scholarly journals Characteristics of Kawasaki Disease Patients during the COVID-19 Pandemic in Japan: A Single-Center, Observational Study

Children ◽  
2021 ◽  
Vol 8 (10) ◽  
pp. 913
Author(s):  
Shoichi Shimizu ◽  
Mamoru Ayusawa ◽  
Hidetoshi Go ◽  
Kimitaka Nakazaki ◽  
Hidemasa Namiki ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Observational Study ◽  
Retrospective Cohort ◽  
Clinical Characteristics ◽  
Macrophage Activation Syndrome ◽  
Macrophage Activation ◽  
Single Center ◽  
Present Stage ◽  
Single Center Observational Study

Background: Under the Coronavirus disease 2019 (COVID-19) pandemic, manifestations in children with Kawasaki disease (KD) are different between the Western and the Eastern countries. Particularly, there has not been a report comparing a series of KD in Japan, where KD was originally discovered and has a large number of registered cases. Methods: We compared patients with KD under the period of the COVID-19 pandemic in Japan with the report from Italy during its reported period by a retrospective, cohort, observational study in a Japanese single center. Results: Thirty-two patients with typical KD were treated during the study period, while the Italian study reported 10 patients with the signs of KD. Concerning the proof of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, none (0%) of our KD cases showed a positive result and one and no patients developed the macrophage activation syndrome (MAS) and Kawasaki disease shock syndrome (KDSS), respectively; however, eight (80%) patients in the Italian series were confirmed with SARS-CoV-2 infection. MAS and KDSS developed in six and five patients, respectively. Conclusions: Cases reported as COVID-19 pandemic-related KD in Italy showed significantly different clinical characteristics from the typical KD symptoms known in Japan. Although they show KD-like manifestations, we cannot conclude that SARS-CoV-2 has the same etiology of our ‘classic‘ KD at the present stage.

scholarly journals Prevalence and risk factor analysis for the nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

Medicine ◽  
2021 ◽  
Vol 100 (10) ◽  
pp. e24940
Author(s):  
Qiumei Zhou ◽  
Yulong Wang ◽  
Jiajia Wang ◽  
Yating Liu ◽  
Dehui Qi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Factor Analysis ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver
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