scholarly journals Carotid-Femoral Pulse Wave Velocity Is Associated With Cerebral White Matter Lesions in Type 2 Diabetes

Diabetes Care ◽  
2012 ◽  
Vol 36 (3) ◽  
pp. 722-728 ◽  
Author(s):  
E. Laugesen ◽  
P. Hoyem ◽  
B. Stausbol-Gron ◽  
A. Mikkelsen ◽  
S. Thrysoe ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
White Matter ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Cerebral White Matter Lesions

Determinants of 1-Year Changes of Brachial Ankle Pulse Wave Velocity (baPWV) in Patients with Type 2 Diabetes Mellitus

2008 ◽  
Vol 32 (4) ◽  
pp. 346 ◽  
Author(s):  
Kyung Won Yun ◽  
Bo Hyun Kim ◽  
Young Pil Bae ◽  
Byeong Do Yi ◽  
Seung Woo Lee ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave

Determinants of the Brachial-Ankle Pulse Wave Velocity (baPWV) in Patients with Type 2 Diabetes Mellitus

2008 ◽  
Vol 23 (4) ◽  
pp. 253 ◽  
Author(s):  
Seong Woo Lee ◽  
Kyung Won Yun ◽  
Yun Sik Yu ◽  
Hong Kyu Lim ◽  
Yung Pil Bae ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave

scholarly journals Association of serum FAM19A5 with metabolic and vascular risk factors in human subjects with or without type 2 diabetes

2019 ◽  
Vol 16 (6) ◽  
pp. 530-538 ◽  
Author(s):  
You-Bin Lee ◽  
Hwan-Jin Hwang ◽  
Jung A Kim ◽  
Soon Young Hwang ◽  
Eun Roh ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Human Subjects ◽  
Glycated Haemoglobin ◽  
Vascular Risk ◽  
Waist To Hip Ratio

Objectives: A recent experimental study revealed that family with sequence similarity 19 [chemokine (C-C motif)-like] member A5 (FAM19A5), a novel secreted adipokine, has inhibitory effects on vascular smooth muscle cell proliferation and migration, and on neointima formation in injured arteries. We investigated the associations between serum FAM19A5 concentration and cardio-metabolic risk factors for the first time in human subjects. Methods: Circulating FAM19A5 concentrations and their associations with cardio-metabolic risk factors were explored in 223 individuals (45 without diabetes and 178 with type 2 diabetes). Results: Serum FAM19A5 concentrations (pg/mL) were greater in patients with type 2 diabetes [median (interquartile range), 172.70 (116.19, 286.42)] compared with non-diabetic subjects [92.09 (70.32, 147.24)] ( p < 0.001). Increasing serum FAM19A5 tertile was associated with trends of increasing waist-to-hip ratio, fasting plasma glucose, glycated haemoglobin and mean brachial-ankle pulse wave velocity. Serum FAM19A5 was positively correlated with waist circumference, waist-to-hip ratio, alanine aminotransferase, fasting plasma glucose, glycated haemoglobin and mean brachial-ankle pulse wave velocity. Multiple stepwise regression analyses identified waist-to-hip ratio, low-density lipoprotein cholesterol and brachial-ankle pulse wave velocity as determining factors for log-transformed serum FAM19A5 concentration (R2 = 0.0689). Conclusion: A novel adipokine FAM19A5 was related to various metabolic and vascular risk factors in humans, suggesting its potential as a biomarker of cardio-metabolic disease.

scholarly journals Association between brachial-ankle pulse wave velocity and risk of type 2 diabetes mellitus: results from a cohort study

2020 ◽  
Vol 8 (1) ◽  
pp. e001317
Author(s):  
Yan-mei Lou ◽  
Min-qi Liao ◽  
Chang-yi Wang ◽  
Hong-en Chen ◽  
Xiao-lin Peng ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cohort Study ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Cox Proportional Hazards ◽  
New Onset

IntroductionBrachial-ankle pulse wave velocity (ba-PWV), as a simple and easily measured marker of arterial stiffness, has not been prospectively explored for its role in type 2 diabetes mellitus (T2DM) risk among the general population. This study aimed to explore the association between baseline ba-PWV value and new-onset T2DM among Chinese adults.Research design and methodsUsing data from Xiaotangshan Hospital, we conducted a prospective cohort study among those who underwent annual or biennial health check-up examinations and who had their ba-PWV measured from 2009 to 2016. We explored the risk of new-onset T2DM across ba-PWV tertiles using Cox proportional-hazards regression analysis.ResultsOf 6122 adults (68.9% male; mean age: 51.0 (SD 13.0) years) without T2DM and with ba-PWV measured at baseline, 599 participants developed T2DM during an average of 3.8 (SD 2.3) years of follow-up. After multivariable adjustment, ba-PWV was positively related to T2DM risk (p for trend=0.008). Compared with the lowest ba-PWV tertile, the HRs and their 95% CIs were 1.57 (1.18 to 2.10) for the second and 1.66 (1.24 to 2.22) for the third tertile. The risk across ba-PWV tertiles increased steadily from 1000 cm/s to 1400 cm/s and then reached a plateau. Subgroup analyses indicated a significantly higher risk among those aged <65 years and current smokers (p for interactions: <0.001 and 0.006).ConclusionsOur findings suggest that ba-PWV might be a useful and independent predictor of new-onset T2DM with ba-PWV ranging between 1000 cm/s and 1400 cm/s, especially among younger individuals and current smokers.

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