Pleural Ultrasound Elastography: A Novel Technique for the Differential Diagnosis of Malignant Pleural Effusion

2018 ◽  
Author(s):  
Bin Jiang ◽  
Xue-lian Li ◽  
Yan Yin ◽  
Qin Zhang ◽  
Tong Zang ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Pleural Effusion ◽  
Malignant Pleural Effusion ◽  
Ultrasound Elastography ◽  
Novel Technique

The Differential Diagnosis in Nonlymphoproliferative Malignant Pleural Effusion Cytopathology and Its Correlation with Patients’ Demographics

2018 ◽  
Vol 62 (5-6) ◽  
pp. 436-442 ◽  
Author(s):  
Erika F. Rodriguez ◽  
Sayanan Chowsilpa ◽  
Zahra Maleki
Keyword(s):  
Differential Diagnosis ◽  
African American ◽  
Pleural Effusion ◽  
Malignant Pleural Effusion ◽  
Primary Site ◽  
Gi Tract ◽  
Asian Patients ◽  
Caucasian Patients ◽  
The Impact ◽  
Upper Gastrointestinal

Background: We report our experience with malignant pleural effusion (MPE) and the impact of patients’ demographics on the differential diagnosis at the primary site. Methods: After IRB approval, we searched our pathology database from January 2013 to January 2017 for patients with positive pleural effusions (PEs). Patients’ demographics and clinical histories were noted. Results: 474 patients were identified (288 females [61%] and 186 males [39%]), ranging in age from 19 to 64 years old. Ethnicity was distributed as follows: Caucasian (n = 330, 70%), African American (n = 114, 24%) and Asian (n = 30, 6%). The most common primary sites were the lung (n = 180, 37%), followed by the breast (n = 81, 17%), and the gynecologic system (67, 13%). The lung was the most common primary for all ethnicities (n = 190, 40%). The second-most common primary site was the breast in African Americans and Caucasians and upper gastrointestinal (GI) tract in Asians. In 5 cases (1%), the primary tumor could not be determined. Conclusion: Cytology examination is a useful method to diagnose primary sites of PE. Pulmonary primary is the most common cause of effusion in all ethnicities. In African American and Caucasian patients, the breast was the second-most common site of MPE, while in Asian patients it was the upper GI tract.

scholarly journals Differential diagnosis between lymphoma-associated malignant pleural effusion and tuberculous pleural effusion

2019 ◽  
Vol 7 (16) ◽  
pp. 373-373 ◽  
Author(s):  
Chang Ho Kim ◽  
Hong Geun Oh ◽  
Sang Yub Lee ◽  
Jae Kwang Lim ◽  
Yong Hoon Lee ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Pleural Effusion ◽  
Malignant Pleural Effusion ◽  
Tuberculous Pleural Effusion

scholarly journals Reactive oxygen species modulator 1, a novel protein, combined with carcinoembryonic antigen in differentiating malignant from benign pleural effusion

Tumor Biology ◽  
2017 ◽  
Vol 39 (5) ◽  
pp. 101042831769837 ◽  
Author(s):  
Xianmeng Chen ◽  
Na Zhang ◽  
Jiahui Dong ◽  
Gengyun Sun
Keyword(s):  
Reactive Oxygen Species ◽  
Differential Diagnosis ◽  
Pleural Effusion ◽  
Carcinoembryonic Antigen ◽  
Sensitivity And Specificity ◽  
Malignant Pleural Effusion ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cutoff Value ◽  
Benign Pleural Effusion

The differential diagnosis of malignant pleural effusion and benign pleural effusion remains a clinical problem. Reactive oxygen species modulator 1 is a novel protein overexpressed in various human tumors. The objective of this study was to evaluate the diagnostic value of joint detection of reactive oxygen species modulator 1 and carcinoembryonic antigen in the differential diagnosis of malignant pleural effusion and benign pleural effusion. One hundred two consecutive patients with pleural effusion (including 52 malignant pleural effusion and 50 benign pleural effusion) were registered in this study. Levels of reactive oxygen species modulator 1 and carcinoembryonic antigen were measured by enzyme-linked immunosorbent assay and radioimmunoassay, respectively. Results showed that the concentrations of reactive oxygen species modulator 1 both in pleural fluid and serum of patients with malignant pleural effusion were significantly higher than those of benign pleural effusion (both p < 0.05). The diagnostic sensitivity and specificity of pleural fluid reactive oxygen species modulator 1 were 61.54% and 82.00%, respectively, with the optimized cutoff value of 589.70 pg/mL. However, the diagnostic sensitivity and specificity of serum reactive oxygen species modulator 1 were only 41.38% and 86.21%, respectively, with the cutoff value of 27.22 ng/mL, indicating that serum reactive oxygen species modulator 1 may not be a good option in the differential diagnosis of malignant pleural effusion and benign pleural effusion. The sensitivity and specificity of pleural fluid carcinoembryonic antigen were 69.23% and 88.00%, respectively, at the cutoff value of 3.05 ng/mL, while serum carcinoembryonic antigen were 80.77% and 72.00% at the cutoff value of 2.60 ng/mL. The sensitivity could be raised to 88.17% in parallel detection of plural fluid reactive oxygen species modulator 1 and carcinoembryonic antigen concentration, and the specificity could be improved to 97.84% in serial detection.

scholarly journals Differential diagnosis between benign and malignant pleural effusion with dual-energy spectral CT

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0193714 ◽  
Author(s):  
Xirong Zhang ◽  
Haifeng Duan ◽  
Yong Yu ◽  
Chunling Ma ◽  
Zhanli Ren ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Pleural Effusion ◽  
Malignant Pleural Effusion ◽  
Dual Energy ◽  
Spectral Ct
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