Ω3 Fatty Acids Activate Ciliary FFAR4 to Trigger Adipogenesis in Perivascular Preadipocytes

2018 ◽  
Author(s):  
Keren I. Hilgendorf ◽  
Carl T. Johnson ◽  
Anja Mezger ◽  
Janos Demeter ◽  
William J. Greenleaf ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Ω3 Fatty Acids

Platelet Aggregation in Finnish Men and Its Relation to Fatty Acids in Platelets, Plasma and Adipose Tissue

1985 ◽  
Vol 54 (03) ◽  
pp. 563-569 ◽  
Author(s):  
M K Salo ◽  
E Vartiainen ◽  
P Puska ◽  
T Nikkari
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Platelet Aggregation ◽  
Acid Composition ◽  
Saturated Fatty Acids ◽  
Free Living ◽  
Ω3 Fatty Acids ◽  
Induced Aggregation

SummaryPlatelet aggregation and its relation to fatty acid composition of platelets, plasma and adipose tissue was determined in 196 randomly selected, free-living, 40-49-year-old men in two regions of Finland (east and southwest) with a nearly twofold difference in the IHD rate.There were no significant east-southwest differences in platelet aggregation induced with ADP, thrombin or epinephrine. ADP-induced platelet secondary aggregation showed significant negative associations with all C20-C22 ω3-fatty acids in platelets (r = -0.26 - -0.40) and with the platelet 20: 5ω3/20: 4ω 6 and ω3/ ω6 ratios, but significant positive correlations with the contents of 18:2 in adipose tissue (r = 0.20) and plasma triglycerides (TG) (r = 0.29). Epinephrine-induced aggregation correlated negatively with 20: 5ω 3 in plasma cholesteryl esters (CE) (r = -0.23) and TG (r = -0.29), and positively with the total percentage of saturated fatty acids in platelets (r = 0.33), but had no significant correlations with any of the ω6-fatty acids. Thrombin-induced aggregation correlated negatively with the ω3/6ω ratio in adipose tissue (r = -0.25) and the 20: 3ω6/20: 4ω 6 ratio in plasma CE (r = -0.27) and free fatty acids (FFA) (r = -0.23), and positively with adipose tissue 18:2 (r = 0.23) and 20:4ω6 (r = 0.22) in plasma phospholipids (PL).The percentages of prostanoid precursors in platelet lipids, i. e. 20: 3ω 6, 20: 4ω 6 and 20 :5ω 3, correlated best with the same fatty acids in plasma CE (r = 0.32 - 0.77) and PL (r = 0.28 - 0.74). Platelet 20: 5ω 3 had highly significant negative correlations with the percentage of 18:2 in adipose tissue and all plasma lipid fractions (r = -0.35 - -0.44).These results suggest that, among a free-living population, relatively small changes in the fatty acid composition of plasma and platelets may be reflected in significant differences in platelet aggregation, and that an increase in linoleate-rich vegetable fat in the diet may not affect platelet function favourably unless it is accompanied by an adequate supply of ω3 fatty acids.

Effect of ω3 fatty acids on oxidative stress in humans: GC–MS measurement of urinary F2-isoprostane excretion

Redox Report ◽  
2000 ◽  
Vol 5 (1) ◽  
pp. 45-46 ◽  
Author(s):  
T.A. Mori ◽  
I.B. Puddey ◽  
V. Burke ◽  
K.D. Croft ◽  
D.W. Dunstan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Ω3 Fatty Acids

Oleogel-structured composite for the stabilization of ω3 fatty acids in fish oil

2018 ◽  
Vol 9 (11) ◽  
pp. 5598-5606 ◽  
Author(s):  
Michelle C. Lee ◽  
Xiaofei Jiang ◽  
J. Thomas Brenna ◽  
Alireza Abbaspourrad
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Whey Protein ◽  
Whey Protein Isolate ◽  
Protein Isolate ◽  
Compartment System ◽  
Cyclodextrin Complexation ◽  
Ω3 Fatty Acids

The fish oil is encapsulated in a multi-compartment system featuring β-cyclodextrin complexation within whey protein isolate (WPI) coated oleogel particles.

Bioaccumulation and Bioconversion of Dietary Labeled Fatty Acids in Artemia and Winter Flounder (Pseudopleuronectes americanus)

1985 ◽  
Vol 42 (8) ◽  
pp. 1430-1438 ◽  
Author(s):  
Paul S. Schauer ◽  
Kenneth L. Simpson
Keyword(s):  
Fatty Acids ◽  
Rice Bran ◽  
Winter Flounder ◽  
Pseudopleuronectes Americanus ◽  
Ω3 Fatty Acids

One-day-old Artemia were fed for 14 d on nine different rice bran diets, most containing either [1-14C]18:2 ω6 or [1-14C]18:3 ω3, along with various nonlabeled fatty acids. The 15-d-old Artemia were then fed as labeled diets to winter flounder (Pseudopleuronectes americanus). Although 18:2 ω6, 18:3 ω3, and 20:5 ω3 were primarily bioaccumulated, all 15-d-old Artemia groups contained some22:6 ω3, even when it was not present in the diet. Therefore, the 15-d-old Artemia had bioconverted small amounts of 18:2 ω6 and 18:3 ω3 to 20:5 ω3 and 22:6 ω3. The bioconversion rate was substantially reduced when either 20:5 ω3 or 22:6 ω3 was present in the diet. When fed the 15-d-old Artemia, the winter flounder accumulated 20:5 ω3 and 22:6 ω3 and also bioconverted some of the 18:3 ω3 to 20:5 ω3 and 22:6 ω3. Those fish fed diets that contained lower levels of 20:5 ω3 and 22:6 ω3 contained higher levels of radioactively labeled 20:5 ω3 and 22:6 ω3. When 20:5 ω3 and 22:6 ω3 were present from the diet, the radioactivity generally accumulated in the 20:4 ω3 and 20:5 ω3 fatty acids.

scholarly journals Reduced prostaglandin F2α release from blood mononuclear leukocytes after oral supplementation of ω3 fatty acids: the OmegAD study

2009 ◽  
Vol 51 (5) ◽  
pp. 1179-1185 ◽  
Author(s):  
Inger Vedin ◽  
Tommy Cederholm ◽  
Yvonne Freund-Levi ◽  
Hans Basun ◽  
Erik Hjorth ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Prostaglandin F2α ◽  
Mononuclear Leukocytes ◽  
Oral Supplementation ◽  
Ω3 Fatty Acids
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