scholarly journals Reduced prostaglandin F2α release from blood mononuclear leukocytes after oral supplementation of ω3 fatty acids: the OmegAD study

2009 ◽  
Vol 51 (5) ◽  
pp. 1179-1185 ◽  
Author(s):  
Inger Vedin ◽  
Tommy Cederholm ◽  
Yvonne Freund-Levi ◽  
Hans Basun ◽  
Erik Hjorth ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Prostaglandin F2α ◽  
Mononuclear Leukocytes ◽  
Oral Supplementation ◽  
Ω3 Fatty Acids

Platelet Aggregation in Finnish Men and Its Relation to Fatty Acids in Platelets, Plasma and Adipose Tissue

1985 ◽  
Vol 54 (03) ◽  
pp. 563-569 ◽  
Author(s):  
M K Salo ◽  
E Vartiainen ◽  
P Puska ◽  
T Nikkari
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Platelet Aggregation ◽  
Acid Composition ◽  
Saturated Fatty Acids ◽  
Free Living ◽  
Ω3 Fatty Acids ◽  
Induced Aggregation

SummaryPlatelet aggregation and its relation to fatty acid composition of platelets, plasma and adipose tissue was determined in 196 randomly selected, free-living, 40-49-year-old men in two regions of Finland (east and southwest) with a nearly twofold difference in the IHD rate.There were no significant east-southwest differences in platelet aggregation induced with ADP, thrombin or epinephrine. ADP-induced platelet secondary aggregation showed significant negative associations with all C20-C22 ω3-fatty acids in platelets (r = -0.26 - -0.40) and with the platelet 20: 5ω3/20: 4ω 6 and ω3/ ω6 ratios, but significant positive correlations with the contents of 18:2 in adipose tissue (r = 0.20) and plasma triglycerides (TG) (r = 0.29). Epinephrine-induced aggregation correlated negatively with 20: 5ω 3 in plasma cholesteryl esters (CE) (r = -0.23) and TG (r = -0.29), and positively with the total percentage of saturated fatty acids in platelets (r = 0.33), but had no significant correlations with any of the ω6-fatty acids. Thrombin-induced aggregation correlated negatively with the ω3/6ω ratio in adipose tissue (r = -0.25) and the 20: 3ω6/20: 4ω 6 ratio in plasma CE (r = -0.27) and free fatty acids (FFA) (r = -0.23), and positively with adipose tissue 18:2 (r = 0.23) and 20:4ω6 (r = 0.22) in plasma phospholipids (PL).The percentages of prostanoid precursors in platelet lipids, i. e. 20: 3ω 6, 20: 4ω 6 and 20 :5ω 3, correlated best with the same fatty acids in plasma CE (r = 0.32 - 0.77) and PL (r = 0.28 - 0.74). Platelet 20: 5ω 3 had highly significant negative correlations with the percentage of 18:2 in adipose tissue and all plasma lipid fractions (r = -0.35 - -0.44).These results suggest that, among a free-living population, relatively small changes in the fatty acid composition of plasma and platelets may be reflected in significant differences in platelet aggregation, and that an increase in linoleate-rich vegetable fat in the diet may not affect platelet function favourably unless it is accompanied by an adequate supply of ω3 fatty acids.

Ω3 Fatty Acids Activate Ciliary FFAR4 to Trigger Adipogenesis in Perivascular Preadipocytes

2018 ◽  
Author(s):  
Keren I. Hilgendorf ◽  
Carl T. Johnson ◽  
Anja Mezger ◽  
Janos Demeter ◽  
William J. Greenleaf ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Ω3 Fatty Acids

scholarly journals Effect of dietary supplementation with omega-3 and -6 on fresh and frozen/thawed sperm quality of dogs

2017 ◽  
Vol 38 (5) ◽  
pp. 3069 ◽  
Author(s):  
Ana Carolina Rodrigues ◽  
Camila Montanari Ruiz ◽  
Carla Daniela Dan De Nardo ◽  
Gabriele Barros Mothé ◽  
Fabiano Martinez Rossi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Sperm Motility ◽  
Sperm Quality ◽  
Dietary Supplementation ◽  
Reproductive Efficiency ◽  
Omega 3 ◽  
Oral Supplementation ◽  
Animal Reproduction ◽  
Fresh Semen

For years, fatty acids have been recommended as a dietary supplement to improve canine hair. For animal reproduction, supplementation with omegas has been used to increase the reproductive efficiency and conception rate, but few studies have been conducted in dogs. The aim of this study was to evaluate the effects of daily dietary supplementation with omega-3 and -6 on the quality of fresh and frozen/thawed semen in canines. Semen was collected from seven dogs and evaluated for sperm motility, vigor, concentration, and morphology. The 17-week study included 119 ejaculates and was divided according to oral supplementation with omega-3 and -6: M1 (1st-5th week) or pre-supplementation; M2 (6th-9th week) and M3 (10th-13th week) or during supplementation; and M4 (14th-17th week) or post-supplementation. After analysis, the semen was frozen and then revaluated both immediately and 30 minutes (at 37° C) after thawing. Supplementation with omegas increased sperm motility, vigor, and concentration; however, supplementation had no influence on semen freezability. In addition, there was no improvement in sperm motility after supplementation when the thawed cells were maintained at 37° C for 30 minutes. We concluded that dietary supplementation with omega-3 and -6 for 4 to 8 weeks can improve the quality of fresh semen, although it has no effect on the freezability of canine semen.

Treatment of EFA deficiency with dietary triglycerides or phospholipids in a murine model of extrahepatic cholestasis

2004 ◽  
Vol 286 (5) ◽  
pp. G822-G832 ◽  
Author(s):  
Anniek Werner ◽  
Rick Havinga ◽  
Folkert Kuipers ◽  
Henkjan J. Verkade
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Bile Duct Ligation ◽  
Murine Models ◽  
High Fat ◽  
Initial Value ◽  
Extrahepatic Cholestasis ◽  
Oral Supplementation ◽  
Duct Ligation ◽  
Long Chain

Essential fatty acid (EFA) deficiency during cholestasis is mainly due to malabsorption of dietary EFA ( 23 ). Theoretically, dietary phospholipids (PL) may have a higher bioavailability than dietary triglycerides (TG) during cholestasis. We developed murine models for EFA deficiency (EFAD) with and without extrahepatic cholestasis and compared the efficacy of oral supplementation of EFA as PL or as TG. EFAD was induced in mice by feeding a high-fat EFAD diet. After 3 wk on this diet, bile duct ligation was performed in a subgroup of mice to establish extrahepatic cholestasis. Cholestatic and noncholestatic EFAD mice continued on the EFAD diet (controls) or were supplemented for 3 wk with EFA-rich TG or EFA-rich PL. Fatty acid composition was determined in plasma, erythrocytes, liver, and brain. After 4 wk of EFAD diet, induction of EFAD was confirmed by a sixfold increased triene-to-tetraene ratio (T/T ratio) in erythrocytes of noncholestatic and cholestatic mice ( P < 0.001). EFA-rich TG and EFA-rich PL were equally effective in preventing further increase of the erythrocyte T/T ratio, which was observed in cholestatic and noncholestatic nonsupplemented mice (12- and 16-fold the initial value, respectively). In cholestatic mice, EFA-rich PL was superior to EFA-rich TG in decreasing T/T ratios of liver TG and PL (each P < 0.05) and in increasing brain PL concentrations of the long-chain polyunsaturated fatty acids (LCPUFA) docosahexaenoic acid and arachidonic acid (each P < 0.05). We conclude that oral EFA supplementation in the form of PL is more effective than in the form of TG in increasing LCPUFA concentrations in liver and brain of cholestatic EFAD mice.

Effect of ω3 fatty acids on oxidative stress in humans: GC–MS measurement of urinary F2-isoprostane excretion

Redox Report ◽  
2000 ◽  
Vol 5 (1) ◽  
pp. 45-46 ◽  
Author(s):  
T.A. Mori ◽  
I.B. Puddey ◽  
V. Burke ◽  
K.D. Croft ◽  
D.W. Dunstan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Ω3 Fatty Acids

Oleogel-structured composite for the stabilization of ω3 fatty acids in fish oil

2018 ◽  
Vol 9 (11) ◽  
pp. 5598-5606 ◽  
Author(s):  
Michelle C. Lee ◽  
Xiaofei Jiang ◽  
J. Thomas Brenna ◽  
Alireza Abbaspourrad
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Whey Protein ◽  
Whey Protein Isolate ◽  
Protein Isolate ◽  
Compartment System ◽  
Cyclodextrin Complexation ◽  
Ω3 Fatty Acids

The fish oil is encapsulated in a multi-compartment system featuring β-cyclodextrin complexation within whey protein isolate (WPI) coated oleogel particles.

PP011-MON RAPID INCORPORATION OF OMEGA-3 FATTY ACIDS INTO COLONIC TISSUE AFTER ORAL SUPPLEMENTATION (II)

2011 ◽  
Vol 6 (1) ◽  
pp. 118-119
Author(s):  
L.S. Sørensen ◽  
H.H. Rasmussen ◽  
I.V. Aardestrup ◽  
O. Thorlacius-Ussing ◽  
K. Varming ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Colonic Tissue ◽  
Oral Supplementation ◽  
Rapid Incorporation
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