Intravenously Administered Iduronate-2-Sulfatase Fused with Anti-Human Transferrin Receptor Antibody (Jr-141) Crosses the Blood-Brain Barrier to Address Central Nervous System Disorders in Hunter Syndrome: A Randomised, Open-Label, Phase 1/2 Trial

2018 ◽  
Author(s):  
Torayuki Okuyama ◽  
Yoshikatsu Eto ◽  
Norio Sakai ◽  
Kohtaro Minami ◽  
Tatsuyoshi Yamamoto ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Transferrin Receptor ◽  
Phase 1 ◽  
Hunter Syndrome ◽  
Open Label ◽  
Central Nervous System Disorders ◽  
Human Transferrin Receptor ◽  
Open Label Phase

Glucocorticoid signalling and resistance at the blood–brain barrier in central nervous system disorders

2012 ◽  
Vol 56 (5-6) ◽  
pp. 355
Author(s):  
Christoph Kleinschnitz ◽  
Kinga Blecharz ◽  
Timo Kahles ◽  
Tobias Schwarz ◽  
Peter Kraft ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Central Nervous System Disorders ◽  
Blood Brain

Central nervous system disorders and damage: Implications for stress, anxiety, and depression

2007 ◽  
Author(s):  
P. S. Seibert ◽  
P. D. Parker ◽  
C. M. Patterson ◽  
N. Whitener ◽  
J. O'Donnell ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Anxiety And Depression ◽  
Central Nervous System Disorders

Ethanolamine: A Potential Promoiety with Additional Effects in the Brain

2020 ◽  
Vol 19 ◽  
Author(s):  
Asfree Gwanyanya ◽  
Christie Nicole Godsmark ◽  
Roisin Kelly-Laubscher
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Design ◽  
Cell Signaling ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
The Central Nervous System ◽  
Bioactive Molecule ◽  
Positive Functions ◽  
The Brain

Abstract: Ethanolamine is a bioactive molecule found in several cells, including those in the central nervous system (CNS). In the brain, ethanolamine and ethanolamine-related molecules have emerged as prodrug moieties that can promote drug movement across the blood-brain barrier. This improvement in the ability to target drugs to the brain may also mean that in the process ethanolamine concentrations in the brain are increased enough for ethanolamine to exert its own neurological ac-tions. Ethanolamine and its associated products have various positive functions ranging from cell signaling to molecular storage, and alterations in their levels have been linked to neurodegenerative conditions such as Alzheimer’s disease. This mini-review focuses on the effects of ethanolamine in the CNS and highlights the possible implications of these effects for drug design.

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