Winner and Losers in Gamification? The Role of Gamification in Third Level Learning and Higher Order Processing

2015 ◽  
Author(s):  
Mairead Brady ◽  
Ann Devitt ◽  
Markus Lamest ◽  
S. Gomez Pearson
Keyword(s):  
Higher Order ◽  
Order Processing

scholarly journals Complex spikes encode reward expectation signals during visuomotor association learning

2019 ◽  
Author(s):  
Naveen Sendhilnathan ◽  
Anna Ipata ◽  
Michael E. Goldberg
Keyword(s):  
Stimulus Onset ◽  
Higher Order ◽  
Independent Manner ◽  
General Role ◽  
Order Processing ◽  
Association Learning ◽  
Reward Delivery ◽  
Spike Signals ◽  
Complex Spikes

AbstractClimbing fiber input to Purkinje cells has been thought to instruct learning related changes in simple spikes and cause behavioral changes through an error-based learning mechanism. Although, this framework explains simple motor learning, it cannot be extended to learning higher-order skills. Recently the cerebellum has been implicated in a variety of cognitive tasks and reward-based learning. Here we show that when a monkey learns a new visuomotor association, complex spikes predict the time of the beginning of the trial in a learning independent manner as well as encode a learning contingent reward expectation signal after the stimulus onset and reward delivery. These complex spike signals are unrelated to and were unlikely to instruct the reward based signal found in the simple spikes. Our results provide a more general role of complex spikes in learning and higher-order processing while gathering evidence for their participation in reward based learning.

The novel guanylyl cyclase MsGC-I is strongly expressed in higher-order neuropils in the brain of Manduca sexta

2001 ◽  
Vol 204 (2) ◽  
pp. 305-314 ◽  
Author(s):  
A. Nighorn ◽  
P.J. Simpson ◽  
D.B. Morton
Keyword(s):  
Nervous System ◽  
Manduca Sexta ◽  
Guanylyl Cyclase ◽  
Higher Order ◽  
Adult Brain ◽  
Central Complex ◽  
Amino Acid Residues ◽  
Order Processing ◽  
Guanylyl Cyclases ◽  
The Brain

Guanylyl cyclases are usually characterized as being either soluble (sGCs) or receptor (rGCs). We have recently cloned a novel guanylyl cyclase, MsGC-I, from the developing nervous system of the hawkmoth Manduca sexta that cannot be classified as either an sGC or an rGC. MsGC-I shows highest sequence identity with receptor guanylyl cyclases throughout its catalytic and dimerization domains, but does not contain the ligand-binding, transmembrane or kinase-like domains characteristic of receptor guanylyl cyclases. In addition, MsGC-I contains a C-terminal extension of 149 amino acid residues. In this paper, we report the expression of MsGC-I in the adult. Northern blots show that it is expressed preferentially in the nervous system, with high levels in the pharate adult brain and antennae. In the antennae, immunohistochemical analyses show that it is expressed in the cell bodies and dendrites, but not axons, of olfactory receptor neurons. In the brain, it is expressed in a variety of sensory neuropils including the antennal and optic lobes. It is also expressed in structures involved in higher-order processing including the mushroom bodies and central complex. This complicated expression pattern suggests that this novel guanylyl cyclase plays an important role in mediating cyclic GMP levels in the nervous system of Manduca sexta.

scholarly journals Dynamics of Extreme Stratospheric Negative Heat Flux Events in an Idealized Model

2018 ◽  
Vol 75 (10) ◽  
pp. 3521-3540 ◽  
Author(s):  
Etienne Dunn-Sigouin ◽  
Tiffany Shaw
Keyword(s):  
Heat Flux ◽  
Wave Propagation ◽  
Recent Work ◽  
Wave Interaction ◽  
Higher Order ◽  
Negative Events ◽  
Flow Mechanism ◽  
Mean Flow ◽  
Idealized Model

Recent work has shown that extreme stratospheric wave-1 negative heat flux events couple with the troposphere via an anomalous wave-1 signal. Here, a dry dynamical core model is used to investigate the dynamical mechanisms underlying the events. Ensemble spectral nudging experiments are used to isolate the role of specific dynamical components: 1) the wave-1 precursor, 2) the stratospheric zonal-mean flow, and 3) the higher-order wavenumbers. The negative events are partially reproduced when nudging the wave-1 precursor and the zonal-mean flow whereas they are not reproduced when nudging either separately. Nudging the wave-1 precursor and the higher-order wavenumbers reproduces the events, including the evolution of the stratospheric zonal-mean flow. Mechanism denial experiments, whereby one component is fixed to the climatology and others are nudged to the event evolution, suggest higher-order wavenumbers play a role by modifying the zonal-mean flow and through stratospheric wave–wave interaction. Nudging all tropospheric wave precursors (wave-1 and higher-order wavenumbers) confirms they are the source of the stratospheric waves. Nudging all stratospheric waves reproduces the tropospheric wave-1 signal. Taken together, the experiments suggest the events are consistent with downward wave propagation from the stratosphere to the troposphere and highlight the key role of higher-order wavenumbers.

Higher order neurons in buccal ganglia of Pleurobranchaea elicit vomiting motor activity

1983 ◽  
Vol 50 (3) ◽  
pp. 658-670 ◽  
Author(s):  
A. D. McClellan
Keyword(s):  
High Frequency ◽  
Motor Pattern ◽  
Higher Order ◽  
Root Activity ◽  
Command Neurons ◽  
Sensory Inputs ◽  
Buccal Ganglia ◽  
Output Pattern ◽  
Stimulation Of

The buccal mass of the gastropod Pleurobranchaea is used during a regurgitation response that consists of a writhing phase interrupted by brief periodic bouts of a vomiting phase (17, 20). During transitions from writhing to vomiting, specific changes occur in the motor pattern (19, 20). Evidence is presented suggesting that at least some of the initiation or "command" neurons for vomiting reside in the buccal ganglia. The present paper examines the role of two candidate vomiting-initiation cells, the ventral white cells (VWC) and midganglionic cells (MC), in the buccal ganglia of isolated nervous systems. Stimulation of single VWCs activates a vomiting motor pattern, consisting in part of alternating buccal root activity. Furthermore, the VWCs fire in high-frequency bursts during episodes (i.e., bouts) of this same vomiting pattern. Mutual reexcitation between the VWCs and motor pattern generator (MPG) appears to produce the accelerated buildup and maintenance of vomiting rhythms. Brief stimulation of single MCs "triggers" bouts of a vomiting motor pattern, but the membrane potential of this cell is only modulated during this same pattern, at least in the isolated nervous system. It is proposed that in intact animals the MCs are activated by sensory inputs and briefly excite the VWC-MPG network, thereby turning on the mutual reexcitatory mechanism mentioned above and switching the output pattern. A general implication for gastropod research is that higher order neurons that activate buccal root activity cannot automatically be given the function of "feeding command neuron," as some cells clearly control other responses, such as vomiting.

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