scholarly journals Refined Best-Response Correspondence and Dynamics

2009 ◽  
Author(s):  
Dieter Balkenborg ◽  
Josef Hofbauer ◽  
Christoph Kuzmics
Keyword(s):  
Best Response ◽  
Best Response Correspondence

The Game of Voting

2011 ◽  
Author(s):  
Michel Balinski ◽  
Rida Laraki
Keyword(s):  
Condorcet Winner ◽  
Election Outcome ◽  
Equilibrium Outcome ◽  
Grade Distribution ◽  
Best Response ◽  
Strong Equilibria ◽  
Majority Judgment ◽  
Best Response Correspondence

This chapter compares majority judgment mechanism to other methods, including first-past-the-post and Borda’s method, among others, in the context of the game of voting. The concept of utilities, which depends on grade distribution of the electorate, is extended to election output. When the identity of the election winner is dependent on the utilities of voters, Condorcet-winner is elected by a large number of strong-equilibria strategy-profiles. The chapter explores best-response correspondence, according to which, if the number of possible equilibria is very small and sometimes unique, the Condorcet-winner emerges as the unique, possible equilibrium outcome and honest votes determine the election outcome.

scholarly journals The refined best-response correspondence in normal form games

2014 ◽  
Vol 44 (1) ◽  
pp. 165-193 ◽  
Author(s):  
Dieter Balkenborg ◽  
Josef Hofbauer ◽  
Christoph Kuzmics
Keyword(s):  
Normal Form ◽  
Normal Form Games ◽  
Best Response ◽  
Best Response Correspondence

Implications

2017 ◽  
Author(s):  
Karl Widerquist ◽  
Grant S. McCall
Keyword(s):  
Property Rights ◽  
The State ◽  
Natural Property ◽  
Government Failure ◽  
State Of Nature ◽  
Best Response ◽  
Lockean Proviso ◽  
Definition Of ◽  
Taking Action ◽  
Disadvantaged People

Earlier chapters of this book found that the Hobbesian hypothesis is false; the Lockean proviso is unfulfilled; contemporary states and property rights systems fail to meet the standard that social contract and natural property rights theories require for their justification. This chapter assesses the implications of those findings for the two theories. Section 1 argues that, whether contractarians accept or reject these findings, they need to clarify their argument to remove equivocation. Section 2 invites efforts to refute this book’s empirical findings. Section 3 discusses a response open only to property rights theorists: concede this book’s empirical findings and blame government failure. Section 4 considers the argument that this book misidentifies the state of nature. Section 5 considers a “bracketing strategy,” which admits that observed stateless societies fit the definition of the state of nature, but argues that they are not the relevant forms of statelessness today. Section 6 discusses the implications of accepting both the truth and relevance of the book’s findings, concluding that the best response is to fulfil the Lockean proviso by taking action to improve the lives of disadvantaged people.

A Case of Duodenal Neuroendocrine Carcinoma Treated with Amrubicin as Second-line Chemotherapy

2015 ◽  
Vol 24 (3) ◽  
pp. 379-382
Author(s):  
Tadahisa Inoue ◽  
Hitoshi Sano ◽  
Takashi Mizushima ◽  
Hirotada Nishie ◽  
Hiroyasu Iwasaki ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Distant Metastases ◽  
Salvage Chemotherapy ◽  
Second Line ◽  
Effective Treatment Option ◽  
Second Line Chemotherapy ◽  
Best Response ◽  
Long Term Effect ◽  
Line Chemotherapy

We present the case of a Japanese man in his 60s with duodenal neuroendocrine carcinoma with distant metastases. Chemotherapy with irinotecan plus cisplatin was initiated as a first-line regimen. However, disease progression was observed after only two cycles. Therefore, amrubicin was administered as a second-line chemotherapy. The patient showed a long-term effect of amrubicin therapy, and the best response was a partial response after seven cycles. For duodenal neuroendocrine carcinoma, amrubicin therapy can be considered an effective treatment option as salvage chemotherapy.

Respon Padi Gogo Terhadap Residu Pupuk Organik

Agrotek ◽  
2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Baso Daeng
Keyword(s):  
Environmental Sustainability ◽  
Upland Rice ◽  
Organic Fertilizer ◽  
Growing Season ◽  
Chicken Manure ◽  
Good Effect ◽  
Best Response ◽  
Different Types ◽  
Main Plot ◽  
Plot Design

<em>The rate of conversion of paddy fields and irrigation water crisis suggest to consider the development of upland rice.� Empowerment of organic-based dryland done to increase rice, as well as environmental sustainability efforts.� The purpose of this experiment was to determine the effect of organic fertilizer residue to upland rice in the second growing season.� Experiments using a split-split plot design.� The main plot consisted of a dosage of 50% and 100% organic fertilizer in the first growing season.� Sub plot consisted of chicken manure (20 tons ha<sup>-1</sup>), <span style="text-decoration: underline;">Centrosema</span>� <span style="text-decoration: underline;">pubescens</span> (4.3 tons ha<sup>-1</sup>) + chicken manure (10 tons ha<sup>-1</sup>), and <span style="text-decoration: underline;">Thitonia</span> <span style="text-decoration: underline;">diversifolia</span> (4.3 tons ha<sup>-1</sup>) + chicken manure (10 tons ha<sup>-1</sup>).� Sub-sub plot consist of Danau Gaung and Batu Tegi varieties.� The different types of fertilizer had no effect on plant productivity.� The addition of <span style="text-decoration: underline;">Thitonia</span> <span style="text-decoration: underline;">diversifolia</span> gave a good effect on some growth variable and its resistance due pathogen attack.� Batu Tegi varieties are varieties that give the best response from an organic fertilizer.� Interaction between dosage, type of fertilizer, and varieties do not provide areal impact.</em>

scholarly journals Social Pressure in Networks Induces Public Good Provision

Games ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 4
Author(s):  
David Jimenez-Gomez
Keyword(s):  
Public Good ◽  
Small Group ◽  
Dynamic Model ◽  
Network Topology ◽  
Social Pressure ◽  
Public Good Provision ◽  
Public Good Game ◽  
The Public ◽  
Best Response ◽  
Good Provision

I develop a dynamic model with forward looking agents, and show that social pressure is effective in generating provision in a public good game: after a small group of agents start contributing to the public good, other agents decide to contribute as well due to a fear of being punished, and this generates contagion in the network. In contrast to earlier models in the literature, contagion happens fast, as part of the best response of fully rational individuals. The network topology has implications for whether contagion starts and the extent to which it spreads. I find conditions under which an agent decides to be the first to contribute in order to generate contagion in the network, as well as conditions for contribution due to a self-fulfilling fear of social pressure.

scholarly journals Short-course IL-15 given as a continuous infusion led to a massive expansion of effective NK cells: implications for combination therapy with antitumor antibodies

2021 ◽  
Vol 9 (4) ◽  
pp. e002193
Author(s):  
Sigrid P Dubois ◽  
Milos D Miljkovic ◽  
Thomas A Fleisher ◽  
Stefania Pittaluga ◽  
Jennifer Hsu-Albert ◽  
...  
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Intravenous Infusion ◽  
Nk Cell ◽  
Continuous Intravenous Infusion ◽  
Dose Escalation Study ◽  
Link Type ◽  
Best Response ◽  
Antitumor Antibodies ◽  
Interleukin 15

BackgroundFull application of cytokines as oncoimmunotherapeutics requires identification of optimal regimens. Our initial effort with intravenous bolus recombinant human interleukin-15 (rhIL-15) was limited by postinfusional reactions. Subcutaneous injection and continuous intravenous infusion for 10 days (CIV-10) provided rhIL-15 with less toxicity with CIV-10 giving the best increases in CD8+ lymphocytes and natural killer (NK) cells. To ease rhIL-15 administration, we shortened time of infusion. Treatment with rhIL-15 at a dose of 3–5 µg/kg as a 5-day continuous intravenous infusion (CIV-5) had no dose-limiting toxicities while effector cell stimulation was comparable to the CIV-10 regimen.MethodsEleven patients with metastatic cancers were treated with rhIL-15 CIV-5, 3 µg (n=4), 4 µg (n=3), and 5 µg/kg/day (n=4) in a phase I dose-escalation study (April 6, 2012).ResultsImpressive expansions of NK cells were seen at all dose levels (mean 34-fold), including CD56bright NK cells (mean 144-fold for 4 µg/kg), as well as an increase in CD8+ T cells (mean 3.38-fold). At 5 µg/kg/day, there were no dose-limiting toxicities but pulmonary capillary leak and slower patient recovery. This led to our choice of the 4 µg/kg as CIV-5 dose for further testing. Cytolytic capacity of CD56bright and CD56dim NK cells was increased by interleukin-15 assayed by antibody-dependent cellular cytotoxicity (ADCC), natural cytotoxicity and natural killer group 2D-mediated cytotoxicity. The best response was stable disease.ConclusionsIL-15 administered as CIV-5 substantially expanded NK cells with increased cytotoxic functions. Tumor-targeting monoclonal antibodies dependent on ADCC as their mechanism of action including alemtuzumab, obinutuzumab, avelumab, and mogamulizumab could benefit from those NK cell expansions and provide a promising therapeutic strategy.Trial registration numbersNCT01572493, NCT03759184, NCT03905135, NCT04185220 and NCT02689453.

scholarly journals Potentiometric Response of Solid-State Sensors Based on Ferric Phosphate for Iron(III) Determination

Sensors ◽  
2021 ◽  
Vol 21 (5) ◽  
pp. 1612
Author(s):  
Andrea Paut ◽  
Ante Prkić ◽  
Ivana Mitar ◽  
Perica Bošković ◽  
Dražan Jozić ◽  
...  
Keyword(s):  
Silver Sulfide ◽  
Potential Change ◽  
Linear Potential ◽  
Response Characteristics ◽  
Potentiometric Response ◽  
Best Response ◽  
Body Design ◽  
Long Lifetime ◽  
First Time

A novel ion-selective electrode with membranes based on iron(III) phosphate and silver sulfide integrated into a completely new electrode body design has been developed for the determination of iron(III) cations. The best response characteristics with linear potential change were found in the iron(III) concentration range from 3.97× 10−5 to 10−2 mol L−1. The detection limit was found to be 2.41× 10−5 mol L−1 with a slope of –20.53 ± 0.63 and regression coefficient of 0.9925, while the quantification limit was 3.97× 10−5 M. The potential change per concentration decade ranged from –13.59 ± 0.54 to –20.53 ± 1.56 for Electrode Body 1 (EB1) and from –17.28 ± 1.04 to –24 ± 1.87 for Electrode Body 2 (EB2), which is presented for the first time in this work. The prepared electrode has a long lifetime and the ability to detect changes in the concentration of iron cations within 20 s. Membrane M1 showed high recoveries in the determination of iron cations in iron(III) standard solutions (98.2–101.2%) as well as in two different pharmaceuticals (98.6–106.5%). This proves that this type of sensor is applicable in the determination of ferric cations in unknown samples, and the fact that all sensor parts are completely manufactured in our laboratory proves the simplicity of the method.

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