Hydrogen-bonded water in laumontite II: Experimental determination of site-specific thermodynamic properties of hydration of the W1 and W5 sites

2003 ◽  
Vol 88 (7) ◽  
pp. 1060-1072 ◽  
Author(s):  
Thráinn Fridriksson ◽  
J. William Carey ◽  
David L. Bish ◽  
Philip S. Neuhoff ◽  
Dennis K. Bird
Keyword(s):  
Thermodynamic Properties ◽  
Experimental Determination ◽  
Site Specific ◽  
Hydrogen Bonded

scholarly journals Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Laurence Abrami ◽  
Tiziano Dallavilla ◽  
Patrick A Sandoz ◽  
Mustafa Demir ◽  
Béatrice Kunz ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Mathematical Modelling ◽  
Experimental Determination ◽  
Kinetic Parameters ◽  
Turnover Rate ◽  
Data Driven ◽  
Lipid Modification ◽  
Site Specific

S-Palmitoylation is the only reversible post-translational lipid modification. Knowledge about the DHHC palmitoyltransferase family is still limited. Here we show that human ZDHHC6, which modifies key proteins of the endoplasmic reticulum, is controlled by an upstream palmitoyltransferase, ZDHHC16, revealing the first palmitoylation cascade. The combination of site specific mutagenesis of the three ZDHHC6 palmitoylation sites, experimental determination of kinetic parameters and data-driven mathematical modelling allowed us to obtain detailed information on the eight differentially palmitoylated ZDHHC6 species. We found that species rapidly interconvert through the action of ZDHHC16 and the Acyl Protein Thioesterase APT2, that each species varies in terms of turnover rate and activity, altogether allowing the cell to robustly tune its ZDHHC6 activity.

Experimental determination of the thermodynamic properties of the Laves phases in the Cr–Fe–Nb system

2016 ◽  
Vol 624 ◽  
pp. 47-54 ◽  
Author(s):  
E.A. Syutkin ◽  
A. Jacob ◽  
C. Schmetterer ◽  
A.V. Khvan ◽  
B. Hallstedt ◽  
...  
Keyword(s):  
Thermodynamic Properties ◽  
Experimental Determination ◽  
Laves Phases
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