scholarly journals Studies on the Metabolic Fate of Levothyroxine-Sodium. (2): Plasma Concentration of T4, T3 and TSH, Urinary Excretion and Protein Binding in Thyroidectomized Dogs.

1994 ◽  
Vol 9 (2) ◽  
pp. 201-223
Author(s):  
Satoshi IWAMURA ◽  
Hiromi MORI ◽  
Noriyuki KUWAYAMA ◽  
Akira FUJIKATA
Keyword(s):  
Plasma Concentration ◽  
Protein Binding ◽  
Urinary Excretion ◽  
Levothyroxine Sodium ◽  
Metabolic Fate

scholarly journals Effect of L-cysteine on plasma concentration and urinary excretion of 1-(tetrahydro-2-furanyl)-5-fluorouracil metabolites.

1991 ◽  
Vol 39 (4) ◽  
pp. 1068-1071
Author(s):  
Nobuo KAWABATA ◽  
Kenichi YANO ◽  
Hiromitsu OHNO ◽  
Toshiaki NAKASHIMA
Keyword(s):  
Plasma Concentration ◽  
Urinary Excretion

Urinary calculi formation in sheep on high wheat grain diets

1982 ◽  
Vol 33 (5) ◽  
pp. 843 ◽  
Author(s):  
IR Godwin ◽  
VJ Williams
Keyword(s):  
Plasma Concentration ◽  
Urinary Excretion ◽  
Urinary Calculi ◽  
Inorganic Phosphorus ◽  
Wheat Grain ◽  
Faecal Output ◽  
The Third ◽  
P Concentration ◽  
Calcium Phosphorus

The effects of calcium, phosphorus and magnesium contents of diets containing different proportions of wheat grain to roughage on the excretion of minerals involved in urinary calculi formation by sheep, were examined in three separate studies: the first, with six sheep, determined the effects of increasing the percentage of wheat grain in the diet on the digestibilities of Ca, P and Mg, the excretion of these three elements in urine and on the propensity of the diets to form calculi; the second involved two sheep and studied the effects of supplementing a 90% grain diet with CaCO3 and roughage on faecal and urinary excretion of Ca, P and Mg; the third was carried out using four sheep fed on a 75 % grain diet and examined the effects of supplementation with extra P, Ca and roughage on Ca, P and Mg excretion. Urinary P concentration was directly correlated with the formation of calculi. Plasma inorganic phosphorus (P,) increased when grain in the diet was 75 % or greater and this led to increased urinary P excretion. The addition of CaCO3 reduced urinary P without large changes in plasma P1 and increased the faecal output of P. Extra roughage added to high grain diets reduced the digestibility of both Ca and P and the plasma concentration and urinary excretion of P. The significance of these findings for the prevention of urinary calculi in sheep is discussed.

scholarly journals Comparison of Isoflavones Among Dietary Intake, Plasma Concentration and Urinary Excretion for Accurate Estimation of Phytoestrogen Intake

2000 ◽  
Vol 10 (2) ◽  
pp. 127-135 ◽  
Author(s):  
Yusuke Arai ◽  
Mariko Uehara ◽  
Yuho Sato ◽  
Mitsuru Kimira ◽  
Akira Eboshida ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Dietary Intake ◽  
Urinary Excretion ◽  
Accurate Estimation

scholarly journals Studies on protein binding of antibiotics. IV. Effect of the binding of drug to 100,000*g supernatant fluid of rabbit liver homogenates on urinary excretion.

1982 ◽  
Vol 35 (11) ◽  
pp. 1603-1609
Author(s):  
YASUO WATANABE ◽  
RIEKO KITAYAMA ◽  
TOSHIO HAYASHI ◽  
YOSHIFUMI NAKASHIMA ◽  
MASASHI NOGUCHI ◽  
...  
Keyword(s):  
Protein Binding ◽  
Urinary Excretion ◽  
Rabbit Liver ◽  
Supernatant Fluid ◽  
Liver Homogenates

ANDROGEN METABOLISM IN CONGENITAL ADRENAL HYPERPLASIA DUE TO 11 β-HYDROXYLASE DEFICIENCY

PEDIATRICS ◽  
1969 ◽  
Vol 44 (2) ◽  
pp. 201-208
Author(s):  
S. Douglas Frasier ◽  
Richard Horton ◽  
Robert A. Ulstrom
Keyword(s):  
Plasma Concentration ◽  
Urinary Excretion ◽  
Congenital Adrenal Hyperplasia ◽  
Conversion Ratio ◽  
Metabolic Clearance ◽  
Adrenal Hyperplasia ◽  
Metabolic Clearance Rate ◽  
Hydroxylase Deficiency ◽  
Glucocorticoid Administration

The plasma concentration of androstenedione and testosterone, metabolic clearance rate of androstenedione, and in vivo conversion ratio of androstenedione to testosterone have been studied in a normotensive 5-year-old female with congenital adrenal hyperplasia due to a deficiency of 11 β-hydroxylase. Prior to glucocorticoid administration, the urinary excretion of 17-ketosteroids varied from 2.2 to 4.9 mg/24 hours, urinary excretion of pregnanetriol varied from 0.7 to 2.2 mg/24 hours, and total 17-hydroxysteroid excretion varied from 1.2 to 7.5 mg/24 hours. Urinary tetrahydro-11-deoxy cortisol (TSH) was detected at a concentration of 550 µg/24 hours. The plasma concentration of androstenedione varied from 100 to 530 mµg/100 ml and the plasma concentration of testosterone varied from 40 to 90 mµg/100 ml. These values are significantly elevated when compared to those obtained in normal prepubertal females. Urinary steroid excretion and plasma androgen concentrations fell to normal in response to glucocorticoid administration. The metabolic clearance rate of androstenedione was 890 liters per day per M2 and the in vivo conversion ratio of androstenedione to testosterone was 11%. The calculated production rate of androstenedione was 4.7 mg per day per M2. Virilization in congenital adrenal hyperplasia due to 11 β-hydroxylase deficiency can be explained by an elevated plasma concentration of testosterone, which can be accounted for on the basis of conversion from androstenedione.

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