scholarly journals A pharmacokinetics study on Oxiracetam in rats. (II): Plasma levels profile, tissue distribution, metabolism and excretion during and after the repeated oral administration.

1991 ◽  
Vol 6 (4) ◽  
pp. 655-664
Author(s):  
Hiroka SHIGETOH ◽  
Satoru YAMAGAMI ◽  
Kazuo UNO ◽  
Noriyasu TAKAYANAGI ◽  
Yoshio ESUMI ◽  
...  
Keyword(s):  
Oral Administration ◽  
Tissue Distribution ◽  
Plasma Levels ◽  
Pharmacokinetics Study

Absorption, Tissue Distribution and Elimination of 4-[3H]-Epigallocatechin Gallate in Beagle Dogs

2003 ◽  
Vol 22 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Robert R. Swezey ◽  
Daphne E. Aldridge ◽  
Susanna E. Le Valley ◽  
James A. Crowell ◽  
Yukihiko Hara ◽  
...  
Keyword(s):  
Oral Administration ◽  
Tissue Distribution ◽  
Plasma Levels ◽  
Half Life ◽  
Peak Plasma ◽  
Parent Compound ◽  
Epigallocatechin Gallate ◽  
Total Radioactivity ◽  
Repeat Dose ◽  
Beagle Dogs

Polyphenols found in tea are potent antioxidants and have inhibitory activity against tumorigenicity. The purpose of the described study was to assess the absorption, tissue distribution, and elimination of epigallocatechin gallate (EGCG), the principal catechin found in green tea, in a nonrodent species. 4-[3H]-EGCG was administered to beagle dogs by intravenous (IV) and oral routes. Following IV administration of 25 mg/kg, radioactivity in the bloodstream resided predominantly in the plasma. Distribution occurred during the first hour, and the plasma levels of total radioactivity declined with a mean half-life of approximately 7 hours. The apparent volume of distribution (0.65 l/kg) indicated wide distribution, and the total body clearance (1.01 ml/min-kg) was low. A subsequent single oral dose (250 mg/kg) was rapidly absorbed, with peak plasma levels at about 1 hour after administration, followed by elimination with a mean half-life of 8.61 hours. The mean area under the curve (AUC) for total radioactivity was approximately 20% of the value following IV administration (corrected for dose administered). Excretion of radioactivity in the feces predominated over urinary excretion following both IV and oral administration of [3H]-EGCG. Tissue distribution was determined 1 hour after an IV dose (25 mg/kg) administered after 27 days of oral treatment with EGCG (250 mg/kg/day) to mimic chronic consumption of tea. Radioactivity was distributed to a variety of epithelial tissues; the highest concentrations were observed in the liver and gastrointestinal tract tissues. Repeat dose oral administration of EGCG resulted in significantly lower blood radioactivity compared to the concentration following a single dose. These results are generally in accord with previous studies in rodents and indicate that, after oral administration, EGCG (as parent compound and metabolites) is widely distributed to tissues where it can exert a chemopreventive effect.

scholarly journals A pharmacokinetics study of Oxiracetam in rats (I): Plasma levels profile, tissue distribution, metabolism and excretion after single administration.

1991 ◽  
Vol 6 (4) ◽  
pp. 637-653
Author(s):  
Hiroka SHIGETOH ◽  
Satoru YAMAGAMI ◽  
Kazuo UNO ◽  
Noriyasu TAKAYANAGI ◽  
Yoshio ESUMI ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Plasma Levels ◽  
Single Administration ◽  
Pharmacokinetics Study

Plasma levels and absorption of methaqualone after oral administration to man

1972 ◽  
Vol 13 (5part1) ◽  
pp. 719-723 ◽  
Author(s):  
Robert N. Morris ◽  
Gwendolyn A. Gunderson ◽  
Steven W. Babcock ◽  
John F. Zaroslinski
Keyword(s):  
Oral Administration ◽  
Plasma Levels

Oral N-acetylcysteine protects against perfluoroisobutene toxicity in rats

1997 ◽  
Vol 16 (4) ◽  
pp. 212-216 ◽  
Author(s):  
Alison F Lailey
Keyword(s):  
Oral Administration ◽  
Pulmonary Oedema ◽  
Plasma Levels ◽  
Pyrolysis Product ◽  
Lavage Fluid ◽  
Lethal Effects ◽  
Duration Of Protection ◽  
Gas Exposure

1 Perfluoroisobutene, a pyrolysis product of polytetra fluoroethene may cause pulmonary oedema and death when inhaled. Oral N-acetylcysteine has shown protection against inhalation of perfluoroisobutene and in this study we have tried to elucidate the mechanism by which protection is mediated. 2 Protection against the lethal effects of inhaled per fluoroisobutene has been shown when N-acetylcys teine has been orally administered 4, 6 or 8 h before gas exposure. 3 Plasma levels of cysteine, glutathione and N-acetylcys teine were increased for up to 7 h following oral administration of Nac. 4 N-acetylcysteine was not detected in the bronchio alveolar lavage fluid following oral administration. 5 Duration of protection in vivo has been related to the duration of increased thiol levels in the plasma.

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