scholarly journals A pharmacokinetics study of Oxiracetam in rats (I): Plasma levels profile, tissue distribution, metabolism and excretion after single administration.

1991 ◽  
Vol 6 (4) ◽  
pp. 637-653
Author(s):  
Hiroka SHIGETOH ◽  
Satoru YAMAGAMI ◽  
Kazuo UNO ◽  
Noriyasu TAKAYANAGI ◽  
Yoshio ESUMI ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Plasma Levels ◽  
Single Administration ◽  
Pharmacokinetics Study

Comparative pharmacokinetics study of anastrozole after single administration and combination with celecoxib

Xenobiotica ◽  
2017 ◽  
Vol 48 (3) ◽  
pp. 279-284
Author(s):  
Xiaoyang Sun ◽  
Mingming Lv ◽  
Binjie Wang ◽  
Simin Zhao ◽  
Ping Guo ◽  
...  
Keyword(s):  
Single Administration ◽  
Pharmacokinetics Study

Absorption, Tissue Distribution and Elimination of 4-[3H]-Epigallocatechin Gallate in Beagle Dogs

2003 ◽  
Vol 22 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Robert R. Swezey ◽  
Daphne E. Aldridge ◽  
Susanna E. Le Valley ◽  
James A. Crowell ◽  
Yukihiko Hara ◽  
...  
Keyword(s):  
Oral Administration ◽  
Tissue Distribution ◽  
Plasma Levels ◽  
Half Life ◽  
Peak Plasma ◽  
Parent Compound ◽  
Epigallocatechin Gallate ◽  
Total Radioactivity ◽  
Repeat Dose ◽  
Beagle Dogs

Polyphenols found in tea are potent antioxidants and have inhibitory activity against tumorigenicity. The purpose of the described study was to assess the absorption, tissue distribution, and elimination of epigallocatechin gallate (EGCG), the principal catechin found in green tea, in a nonrodent species. 4-[3H]-EGCG was administered to beagle dogs by intravenous (IV) and oral routes. Following IV administration of 25 mg/kg, radioactivity in the bloodstream resided predominantly in the plasma. Distribution occurred during the first hour, and the plasma levels of total radioactivity declined with a mean half-life of approximately 7 hours. The apparent volume of distribution (0.65 l/kg) indicated wide distribution, and the total body clearance (1.01 ml/min-kg) was low. A subsequent single oral dose (250 mg/kg) was rapidly absorbed, with peak plasma levels at about 1 hour after administration, followed by elimination with a mean half-life of 8.61 hours. The mean area under the curve (AUC) for total radioactivity was approximately 20% of the value following IV administration (corrected for dose administered). Excretion of radioactivity in the feces predominated over urinary excretion following both IV and oral administration of [3H]-EGCG. Tissue distribution was determined 1 hour after an IV dose (25 mg/kg) administered after 27 days of oral treatment with EGCG (250 mg/kg/day) to mimic chronic consumption of tea. Radioactivity was distributed to a variety of epithelial tissues; the highest concentrations were observed in the liver and gastrointestinal tract tissues. Repeat dose oral administration of EGCG resulted in significantly lower blood radioactivity compared to the concentration following a single dose. These results are generally in accord with previous studies in rodents and indicate that, after oral administration, EGCG (as parent compound and metabolites) is widely distributed to tissues where it can exert a chemopreventive effect.

Plasma and Tissue Distribution of Adriamycin in Patients with Pelvic Cancer

1981 ◽  
Vol 67 (6) ◽  
pp. 533-537 ◽  
Author(s):  
Elena Piazza ◽  
Nicola Natale ◽  
Ada Trabattoni ◽  
Cesare Mariscotti ◽  
Leonardo Mosca ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Ascitic Fluid ◽  
Plasma Levels ◽  
Invasive Tumor ◽  
Pelvic Cancer ◽  
Cutaneous Tissue ◽  
Fluorescent Compounds ◽  
Neoplastic Tissues

The levels of adriamycin in plasma, ascitic fluid and normal and neoplastic tissues sampled during surgery of 3 patients with advanced pelvic cancer were measured by fluorimetry. The highest content of fluorescent compounds was found in tumoral masses in necrotic or scarcely viable tissue; viable and invasive tumor areas scored fluorescence levels comparable with normal adnexa. Ascitic fluid contained levels of fluorescence comparable to the last observed phase of plasma levels. Adipose and cutaneous tissue scored the lowest concentrations.

Urokinase type plasminogen activator and inhibitor type-1 plasma levels in colorectal cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A599-A600 ◽  
Author(s):  
L HERSZENYI ◽  
F FARINATI ◽  
G ISTVAN ◽  
M PAOLI ◽  
G ROVERONI ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Plasminogen Activator ◽  
Plasma Levels ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Inhibitor Type
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