Lessons from the Crystallographic Analysis of Small Molecule Binding to Human Serum Albumin

2009 ◽  
Vol 24 (4) ◽  
pp. 342-357 ◽  
Author(s):  
Stephen Curry
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Small Molecule ◽  
Crystallographic Analysis

Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin

2010 ◽  
Vol 171 (3) ◽  
pp. 353-360 ◽  
Author(s):  
Kim Langmach Hein ◽  
Ulrich Kragh-Hansen ◽  
J. Preben Morth ◽  
Martin D. Jeppesen ◽  
Daniel Otzen ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Binding Site ◽  
Crystallographic Analysis

scholarly journals Protein encapsulation: a new approach for improving the capability of small-molecule fluorogenic probes

2020 ◽  
Vol 11 (4) ◽  
pp. 1107-1113 ◽  
Author(s):  
Hai-Hao Han ◽  
Adam C. Sedgwick ◽  
Ying Shang ◽  
Na Li ◽  
Tingting Liu ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Fluorescent Probe ◽  
Small Molecule ◽  
Protein Encapsulation ◽  
New Approach ◽  
Fluorogenic Probes ◽  
Guest Chemistry

Herein, we report a protein-based hybridization strategy that exploits the host–guest chemistry of HSA (human serum albumin) to solubilize the otherwise cell impermeable ONOO− fluorescent probe Pinkment-OAc.

In Vivo Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders

2021 ◽  
Vol 32 (2) ◽  
pp. 279-289
Author(s):  
Julien C. Vantourout ◽  
Andrew M. Mason ◽  
Josephine Yuen ◽  
Graham L. Simpson ◽  
Ghotas Evindar ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Small Molecule ◽  
Half Life ◽  
Life Extension ◽  
Metalloproteinase Inhibitors

scholarly journals A fluorescence-based high throughput assay for the determination of small molecule−human serum albumin protein binding

2014 ◽  
Vol 406 (7) ◽  
pp. 1867-1875 ◽  
Author(s):  
Megan M. McCallum ◽  
Alan J. Pawlak ◽  
William R. Shadrick ◽  
Anton Simeonov ◽  
Ajit Jadhav ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Protein Binding ◽  
Human Serum ◽  
Small Molecule ◽  
High Throughput ◽  
High Throughput Assay

scholarly journals Crystallographic Analysis of Human Serum Albumin Complexed with 4Z,15E-Bilirubin-IXα

2008 ◽  
Vol 381 (2) ◽  
pp. 394-406 ◽  
Author(s):  
Patricia A. Zunszain ◽  
Jamie Ghuman ◽  
Antony F. McDonagh ◽  
Stephen Curry
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Crystallographic Analysis
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