scholarly journals Human Serum Albumin-modified Fe3O4 Magnetic Nanoparticles for Affinity-SALDI-MS of Small-Molecule Drugs in Biological Liquids

2012 ◽  
Vol 28 (9) ◽  
pp. 893-900 ◽  
Author(s):  
Yuichi IWAKI ◽  
Hideya KAWASAKI ◽  
Ryuichi ARAKAWA
Keyword(s):  
Magnetic Nanoparticles ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Small Molecule ◽  
Fe3o4 Magnetic Nanoparticles ◽  
Small Molecule Drugs ◽  
Biological Liquids ◽  
Saldi Ms

Interaction Between Ketoconazole and Human Serum Albumin on Epoxy Modified Magnetic Nanoparticles for Drug Delivery

2013 ◽  
Vol 13 (10) ◽  
pp. 6522-6528 ◽  
Author(s):  
Esra Maltas ◽  
Mustafa Ozmen ◽  
Burak Yildirimer ◽  
Semahat Kucukkolbasi ◽  
Salih Yildiz
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Modified Magnetic Nanoparticles

scholarly journals A Rapid Study of Botanical Drug–Drug Interaction with Protein by Re-ligand Fishing using Human Serum Albumin–Functionalized Magnetic Nanoparticles

2015 ◽  
Vol 10 (12) ◽  
pp. 1934578X1501001
Author(s):  
Lin-Sen Qing ◽  
Ying Xue ◽  
Li-Sheng Ding ◽  
Yi-Ming Liu ◽  
Jian Liang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Free Form ◽  
Steroidal Saponins ◽  
Competitive Situation ◽  
Functionalized Magnetic Nanoparticles ◽  
Botanical Drug ◽  
Ligand Fishing

A great many active constituents of botanical drugs bind to human serum albumin (HSA) reversibly with a dynamic balance between the free- and bound-forms in blood. The curative or side effect of a drug depends on its free-form level, which is always influenced by other drugs, combined dosed or multi-constituents of botanical drugs. This paper presented a rapid and convenient methodology to investigate the drug-drug interactions with HSA. The interaction of two steroidal saponins, dioscin and pseudo-protodioscin, from a botanical drug was studied for their equilibrium time and equilibrium amount by re-ligand fishing using HSA functionalized magnetic nanoparticles. A clear competitive situation was obtained by this method. The equilibrium was reached soon about 15 s at a ratio of 0.44: 1. Furthermore, the interaction of pseudo-protodioscin to total steroidal saponins from DAXXK was also studied. The operation procedures of this method were faster and more convenient compared with other methods reported.

scholarly journals Protein encapsulation: a new approach for improving the capability of small-molecule fluorogenic probes

2020 ◽  
Vol 11 (4) ◽  
pp. 1107-1113 ◽  
Author(s):  
Hai-Hao Han ◽  
Adam C. Sedgwick ◽  
Ying Shang ◽  
Na Li ◽  
Tingting Liu ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Fluorescent Probe ◽  
Small Molecule ◽  
Protein Encapsulation ◽  
New Approach ◽  
Fluorogenic Probes ◽  
Guest Chemistry

Herein, we report a protein-based hybridization strategy that exploits the host–guest chemistry of HSA (human serum albumin) to solubilize the otherwise cell impermeable ONOO− fluorescent probe Pinkment-OAc.

In Vivo Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders

2021 ◽  
Vol 32 (2) ◽  
pp. 279-289
Author(s):  
Julien C. Vantourout ◽  
Andrew M. Mason ◽  
Josephine Yuen ◽  
Graham L. Simpson ◽  
Ghotas Evindar ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Small Molecule ◽  
Half Life ◽  
Life Extension ◽  
Metalloproteinase Inhibitors

scholarly journals A fluorescence-based high throughput assay for the determination of small molecule−human serum albumin protein binding

2014 ◽  
Vol 406 (7) ◽  
pp. 1867-1875 ◽  
Author(s):  
Megan M. McCallum ◽  
Alan J. Pawlak ◽  
William R. Shadrick ◽  
Anton Simeonov ◽  
Ajit Jadhav ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Protein Binding ◽  
Human Serum ◽  
Small Molecule ◽  
High Throughput ◽  
High Throughput Assay

Human serum albumin as an effective coating for hydrophobic photosensitizes immobilization on magnetic nanoparticles

2019 ◽  
Vol 475 ◽  
pp. 108-114 ◽  
Author(s):  
Petr Ostroverkhov ◽  
Alevtina Semkina ◽  
Aleksey Nikitin ◽  
Alexander Smirnov ◽  
Daria Vedenyapina ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum
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