Targeted Delivery Systems of Small Interfering RNA by Systemic Administration

2007 ◽  
Vol 22 (3) ◽  
pp. 142-151 ◽  
Author(s):  
Shigeru Kawakami ◽  
Mitsuru Hashida
Keyword(s):  
Targeted Delivery ◽  
Small Interfering Rna ◽  
Delivery Systems ◽  
Systemic Administration ◽  
Interfering Rna ◽  
Targeted Delivery Systems

scholarly journals Targeted Delivery Systems for Molecular Therapy in Skeletal Disorders

2016 ◽  
Vol 17 (3) ◽  
pp. 428 ◽  
Author(s):  
Lei Dang ◽  
Jin Liu ◽  
Fangfei Li ◽  
Luyao Wang ◽  
Defang Li ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Delivery Systems ◽  
Molecular Therapy ◽  
Skeletal Disorders ◽  
Targeted Delivery Systems

scholarly journals Release of siRNA from Liposomes Induced by Curcumin

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Kazuyo Fujita ◽  
Yoshie Hiramatsu ◽  
Hideki Minematsu ◽  
Masaharu Somiya ◽  
Shun’ichi Kuroda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dose Response ◽  
Small Interfering Rna ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Experimental Conditions ◽  
Large Molecules ◽  
Maximal Induction ◽  
Interfering Rna ◽  
Bell Shaped Curve

Liposomes are a potential carrier of small interfering RNA (siRNA) for drug delivery systems (DDS). In this study, we searched for a molecule capable of controlling the release of siRNA from a certain type of liposomes and found that curcumin could induce the release of siRNA from the liposomes encapsulating siRNA within 30 min. However, the release of siRNA from the liposomes by curcumin showed a unique dose-response (i.e., bell-shaped curve) with a maximal induction at around 60 μg/ml of curcumin. Liposomal lipid compositions and temperatures influenced the efficiency in the release of siRNA induced by curcumin. About 10% of curcumin at a 60 μg/ml dose was incorporated into the liposomes within 30 min under our experimental conditions. Our results suggest a possibility that curcumin is useful in controlling the permeability of liposomes carrying large molecules like siRNA.

scholarly journals Natural Polysaccharides for siRNA Delivery: Nanocarriers Based on Chitosan, Hyaluronic Acid, and Their Derivatives

Molecules ◽  
2019 ◽  
Vol 24 (14) ◽  
pp. 2570 ◽  
Author(s):  
Inés Serrano-Sevilla ◽  
Álvaro Artiga ◽  
Scott G. Mitchell ◽  
Laura De Matteis ◽  
Jesús M. de la Fuente
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Small Interfering Rna ◽  
Drug Delivery Systems ◽  
Sirna Delivery ◽  
Delivery Systems ◽  
Low Toxicity ◽  
Interfering Rna

Natural polysaccharides are frequently used in the design of drug delivery systems due to their biocompatibility, biodegradability, and low toxicity. Moreover, they are diverse in structure, size, and charge, and their chemical functional groups can be easily modified to match the needs of the final application and mode of administration. This review focuses on polysaccharidic nanocarriers based on chitosan and hyaluronic acid for small interfering RNA (siRNA) delivery, which are highly positively and negatively charged, respectively. The key properties, strengths, and drawbacks of each polysaccharide are discussed. In addition, their use as efficient nanodelivery systems for gene silencing applications is put into context using the most recent examples from the literature. The latest advances in this field illustrate effectively how chitosan and hyaluronic acid can be modified or associated with other molecules in order to overcome their limitations to produce optimized siRNA delivery systems with promising in vitro and in vivo results.

Design of cyclic RGD-conjugated Aib-containing amphipathic helical peptides for targeted delivery of small interfering RNA

2016 ◽  
Vol 24 (18) ◽  
pp. 4478-4485 ◽  
Author(s):  
Shun-ichi Wada ◽  
Masashi Iwata ◽  
Yuka Ozaki ◽  
Takashi Ozaki ◽  
Junsuke Hayashi ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Small Interfering Rna ◽  
Helical Peptides ◽  
Interfering Rna

Cellular internalization of targeted and non-targeted delivery systems for contrast agents based on polyamidoamine dendrimers

2020 ◽  
Vol 69 (4) ◽  
pp. 793-803
Author(s):  
M. B. Sokol ◽  
M. R. Faustova ◽  
E. D. Nikolskaya ◽  
O. A. Zhunina ◽  
M. V. Fomicheva ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Targeted Delivery ◽  
Delivery Systems ◽  
Cellular Internalization ◽  
Polyamidoamine Dendrimers ◽  
Targeted Delivery Systems
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