Population Pharmacokinetics of Pranlukast Hydrate Dry Syrup in Children with Allergic Rhinitis and Bronchial Asthma

2006 ◽  
Vol 21 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Susumu Nakade ◽  
Shinya Ueda ◽  
Tomoya Ohno ◽  
Kazuki Nakayama ◽  
Yasuyuki Miyata ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Population Pharmacokinetics ◽  
Bronchial Asthma

scholarly journals Population Pharmacokinetics of Ramatroban in Healthy Volunteers and Patients with Bronchial Asthma/Perennial Allergic Rhinitis.

1997 ◽  
Vol 12 (2) ◽  
pp. 121-129
Author(s):  
Takahiko TANIGAWA ◽  
Kazuhito OKUMURA ◽  
Koichi KAWANO ◽  
Takamichi MATSUKI ◽  
Eiji YUKAWA ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Healthy Volunteers ◽  
Population Pharmacokinetics ◽  
Bronchial Asthma ◽  
Perennial Allergic Rhinitis

Atopic dermatitis: new horizons of therapy

2019 ◽  
Vol 1 (7) ◽  
pp. 29-32 ◽  
Author(s):  
L. S. Kruglova ◽  
E. M. Gensler
Keyword(s):  
Blood Pressure ◽  
Immune Response ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Targeted Therapy ◽  
Inflammatory Response ◽  
Bronchial Asthma ◽  
New Horizons ◽  
The Past

Over the past decades, the first breakthrough milestone in the treatment of severe forms of atopic dermatitis (AD) has been targeted therapy aimed at inhibiting IL-4 and IL-13. This was made possible thanks to advances in the understanding of the pathogenesis of AD, the driver of which is the Th2-type immune response, which also underlies such manifestations of atopy as bronchial asthma, allergic rhinitis, and polynosis. In the case of the Th2-type immune response, cytokines IL-4 and IL-13 are secreted, which are the main promoters of the inflammatory response in AD. Inhibition of IL-4 and IL-13 leads to the prevention of inflammation and is an effective approach to therapy. The use of therapy aimed at inhibition of cytokines allows you to effectively cope with the manifestations of severe and moderately severe blood pressure.

ОЦЕНКА ЦИТОКИНОВОГО ПРОФИЛЯ СЫВОРОТКИ КРОВИ И СУБПОПУЛЯЦИЙ Т-ЛИМФОЦИТОВ У ДЕТЕЙ С АЛЛЕРГИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ ОРГАНОВ ДЫХАНИЯ

2019 ◽  
pp. 52-60
Author(s):  
E.V. Prosekova ◽  
A.I. Turyanskaya ◽  
N.G. Plekhova ◽  
M.S. Dolgopolov ◽  
V.A. Sabynych
Keyword(s):  
Allergic Rhinitis ◽  
Bronchial Asthma ◽  
Allergic Inflammation ◽  
Allergic Diseases ◽  
Control Group ◽  
Healthy Children ◽  
Serum Cytokine ◽  
Immunological Parameters ◽  
Low Level ◽  
Level Of Significance

Расширение спектра изучаемых клонов Тхелперов определило более сложные иммунные механизмы реализации аллергического воспаления. Цель. Характеристика показателей и взаимосвязей цитокинового профиля сыворотки и субпопуляционного состава Тлимфоцитов периферической крови у детей с бронхиальной астмой и аллергическим ринитом. Материалы и методы. Проведено комплексное обследование 150 детей в возрасте 311 лет с верифицированным диагнозом бронхиальной астмы, аллергического ринита и 30 здоровых сверстников. Иммунологические параметры крови оценивали методом проточной цитометрии, концентрации интерлейкинов и IgE в сыворотке крови определяли методом твердофазного иммуноферментного анализа. При статистической обработке использовали программы Statistica 10 с критическим уровнем значимости р0,05. Результаты. У детей с аллергическими заболеваниями в сыворотке крови определены высокие уровни содержания интерлейкинов4, 8, 13, 17А, сопоставимый с показателями группы контроля уровень IL17F и низкое содержание IFNy. При бронхиальной астме и аллергическом рините у детей выявлено увеличение количества CD3CD8CD45RO, CD3CD8CD45RACD45RO Тлимфоцитов и CD3CD4 Тхелперов и повышение количество Th17 при снижении CD3CD4CD45RO клеток памяти. В группе здоровых детей популяция Th17 составляла 9,491,6, у детей с аллергическими заболеваниями количество данных клеток было значимо выше 14,50,77 (р0,001). Анализ сывороточного содержания цитокинов у детей с изолированным течением БА и в сочетании с аллергическим ринитом выявил разнонаправленные корреляции, отличающиеся по силе и направленности от таковых в группе здоровых детей. Заключение. У детей при изолированном течении бронхиальной астмы и в сочетании с аллергическим ринитом выявлены: сопоставимое с показателями здоровых детей количество CD3CD4 Тклеток, дисбаланс в субпопуляционном составе Тхелперов за счет преобладания Th2 и Th17, активация синтеза IL17A, IL4, IL8, IL13, низкий уровень сывороточного IFNy, изменения силы и направленности взаимосвязей цитокинового профиля и спектра субпопуляций Тлимфоцитов.Expansion of the range of examined Thelper clones has determined more complex immune mechanisms for the implementation of allergic inflammation. Objective. To characterize the parameters and relationships between the serum cytokine profile and Tlymphocyte subpopulation in peripheral blood of children with bronchial asthma and allergic rhinitis. Materials and methods. 150 children aged between 311 years old with bronchial asthma, and allergic rhinitis and 30 healthy volunteers were examined. Immunological parameters were assessed by flow cytometry, the concentration of serum interleukins and IgE were determined by means of enzymelinked immunosorbent assay. Statistical analysis was performed with Statistica 10 program with a critical level of significance p0.05. Results. High levels of interleukins 4, 8, 13, 17A were determined, IL7F level was not significantly different from that in control group and low level of IFNy was found in the serum of children with allergic diseases. The number of CD3CD8CD45RO, CD3CD8CD45RACD45RO Tlymphocytes, CD3CD4 Thelper cells and Th17 were increased and at the same time CD3CD4CD45RO memory cells were decreased In bronchial asthma and allergic rhinitis children. Number of Th17 cells in healthy children was 9.491.6, in allergic children it was significantly higher 14.50.77 (p0.001). Analyses of serum cytokine count in children with isolated BA and in association with allergic rhinitis revealed multidirectional correlations differing in strength and direction from those in the group of healthy children. Conclusion. In children with isolated bronchial asthma and associated with allergic rhinitis the following parameters were found: CD3CD4 Tcells count was comparable to that in healthy children, the imbalance of Thelper subpopulation: prevalence of Th2 and Th17, activation of IL17A, IL4, IL8, IL13 synthesis and low level of serum IFNy.

Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma

2007 ◽  
Vol 59 (9-10) ◽  
pp. 852-882 ◽  
Author(s):  
Michael H. Smolensky ◽  
Bjoern Lemmer ◽  
Alain E. Reinberg
Keyword(s):  
Allergic Rhinitis ◽  
Bronchial Asthma

scholarly journals A study on prevalence and effects of allergic rhinitis and asthma on quality of life among secondary school’s student in Kinta District, Perak

2019 ◽  
Vol 10 (SPL1) ◽  
Author(s):  
Soe AK ◽  
Aizat AF ◽  
Bellahcene MA ◽  
Atiqah N ◽  
Husna N
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Secondary School ◽  
Bronchial Asthma ◽  
Secondary School Students ◽  
School Students ◽  
Cross Sectional ◽  
Chronic Respiratory Diseases ◽  
Validated Questionnaire

Allergic rhinitis (AR) and bronchial asthma (BA) are common inflammatory chronic respiratory diseases, and they are significant public health challenges on a global scale. The prevalence of these diseases are on the rise in all regions of the world, affecting all ages but more commonly among children and adolescences. Both AR and BA affect patients to a different extent with variable restrictions in the physical, emotional, and social aspects of the patient's life. They may be seen as two presentations of the same disease by sharing common epidemiologic, histologic, physiologic, and immunopathologic linkages. To determine the prevalence and impact of allergic rhinitis, asthma and allergic rhinitis with asthma on quality of life among secondary school students in Kinta District, Perak. A cross-sectional study was done among secondary school students from randomly selected three schools in Kinta District, Ipoh, Perak. A well-vetted and validated questionnaire was used to collect the data, and statistical analysis was done to determine the prevalence and impact of AR, BA, or both. A total of 250 secondary school students were involved in this study. Malays were the majority among the participants. The prevalence of AR alone, BA alone, and disease co-occurance were 27.2%, 9.2%, and 8%, respectively. Nearly 20% of the participants were troublesome but low scale in terms of quality of life followed by disturbed sleep, restricted participation in school, and daily activities. Only 6% of the participants experienced sleep disturbance due to asthma, but daily anti-asthmatic medication was essential in only 1.2%. This study showed that although a relatively high prevalence of allergic rhinitis and bronchial asthma. There was no significant low quality of life among sufferers.  

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