scholarly journals Metabolic Fate of SK-896, a New Human Motilin Analogue ([Leu13]motilin-Hse). (III): Feto-Placental Transfer and Excretion into Milk in Rats after Single Intravenous Injection of 3H-SK-896.

2001 ◽  
Vol 16 (6) ◽  
pp. 528-536
Author(s):  
Yoshiyuki FURUTA ◽  
Yasusuke HORI ◽  
Yasutomi MITOH ◽  
Yukiharu NAKAYAMA ◽  
Yoshio SUZUKI
Keyword(s):  
Intravenous Injection ◽  
Placental Transfer ◽  
Metabolic Fate ◽  
Single Intravenous Injection

Radioautographic Observations on the Uptake and Distribution of Chromium-51 in Mice

1972 ◽  
Vol 11 (04) ◽  
pp. 419-427
Author(s):  
R. Söremark ◽  
M. Diab
Keyword(s):  
Intravenous Injection ◽  
Placental Transfer ◽  
Whole Body ◽  
Pregnant Mother ◽  
Single Intravenous Injection ◽  
Fetal Bone ◽  
Blood Brain ◽  
Hard Tissues ◽  
Yolk Sack

SummaryThe distribuition of 51Cr has been studied in mice by whole-body radioautography after a single intravenous injection of 51CrCl3.Hard tissues, skin, liver, cartilage and yolk sack epithelium were the tissues showing the highest concentration of radiochromium. Blood, brain, muscles and the pancreas showed a low uptake of 51Cr. A placental transfer of chromium from the pregnant mother to the fetus was demonstrated. An uptake in the fetal bone and skin was visible.

Pharmacokinetic profile and placental transfer of a single intravenous injection of [ 14 C]chlorpyrifos in pregnant rats

2002 ◽  
Vol 76 (8) ◽  
pp. 452-459 ◽  
Author(s):  
Ali Abdel-Rahman ◽  
Gregory Blumenthal ◽  
Sherif Abou-Donia ◽  
Fouad Ali ◽  
Abdel-Monem A. ◽  
...  
Keyword(s):  
Intravenous Injection ◽  
Placental Transfer ◽  
Pharmacokinetic Profile ◽  
Pregnant Rats ◽  
Single Intravenous Injection

RATE OF DISAPPEARANCE OF GROWTH HORMONE FROM THE PLASMA OF RATS AFTER A SINGLE INTRAVENOUS INJECTION

1955 ◽  
Vol 19 (2) ◽  
pp. 181-184 ◽  
Author(s):  
Carl A. Gemzell ◽  
Frank Heijkenskjöld ◽  
Lars Ström
Keyword(s):  
Growth Hormone ◽  
Intravenous Injection ◽  
Single Intravenous Injection

Metabolic fate of the new .BETA.-adrenoceptor antagonist, bisoprolol, in animals (3): Foeto-placental transfer and excretion into milk of 14C-bisoprolol in rats.

1989 ◽  
Vol 4 (2) ◽  
pp. 173-185
Author(s):  
Yasuhiro YAMADA ◽  
Mika NAKAHARA ◽  
Kazuaki NAITO ◽  
Michihiro KOHNO ◽  
Minezo OTSUKA ◽  
...  
Keyword(s):  
Placental Transfer ◽  
Metabolic Fate ◽  
Beta Adrenoceptor ◽  
Adrenoceptor Antagonist

The Distribution of [14C]Cholesterol in Muscle and Skin of Rhesus Monkeys after Intravenous Injection

1976 ◽  
Vol 50 (4) ◽  
pp. 307-310
Author(s):  
C. D. Moutafis ◽  
N. B. Myant
Keyword(s):  
Intravenous Injection ◽  
Rhesus Monkeys ◽  
Plasma Cholesterol ◽  
Specific Radioactivity ◽  
Compartment System ◽  
Local Synthesis ◽  
Single Intravenous Injection ◽  
Small Pool ◽  
Slow Turnover

1. The specific radioactivity of [14C]cholesterol in plasma and in serial biopsies of muscle and skin was measured in Rhesus monkeys for 156 days after a single intravenous injection of [14C]cholesterol. 2. Analysis of the specific radioactivity—time curves in terms of a two-compartment system indicated that all the cholesterol of muscle is exchangeable with the plasma cholesterol and that local synthesis does not contribute significantly to the cholesterol in muscle. 3. Analysis of the curve for specific radioactivity of skin cholesterol suggested the presence of a small pool of cholesterol with slow turnover. A contribution to skin cholesterol from local synthesis could not be excluded.

Pharmacokinetics and Tissue Residues of Sulfathiazole and Sulfamethazine in Pigs

1994 ◽  
Vol 57 (9) ◽  
pp. 796-801 ◽  
Author(s):  
LIEVE S. G. VAN POUCKE ◽  
CARLOS H. VAN PETEGHEM
Keyword(s):  
Intravenous Injection ◽  
Half Life ◽  
Intramuscular Injection ◽  
Compartment Model ◽  
Absolute Bioavailability ◽  
Pharmacokinetic Parameters ◽  
Tissue Concentrations ◽  
Single Intravenous Injection ◽  
The Individual ◽  
Residue Study

The plasma pharmacokinetics and tissue penetration of sulfathiazole (ST) and sulfamethazine (SM) after intravenous and intramuscular injection in pigs were studied. Following a single intravenous dose of 40 mg ST/kg of bodyweight or 80 mg SM/kg of bodyweight, the plasma ST and SM concentrations were best fitted to a two-compartment model. The areas under the curve were 447 ± 39 and 1485 ± 41 mg/h/L, clearances were 0.090 ± 0.007 and 0.054 ± 0.001 L/kg/h, volumes of distribution were 1.16 ± 0.16 and 0.77 ± 0.06 L/kg, half-lifes in distribution phase were l.18 ± 0.57 and 0.23 ± 0.16 h and half-lifes in eliminations phase were 9.0 ± l.6 and 9.8 ± 0.6 h. When the two compounds were administered simultaneously as a single intravenous injection, the pharmacokinetic parameters for ST were not significantly different. The values for SM show statistical differences for some important parameters: α, β and the AUC0–>∞ were significantly decreased and t1/2α, Vd and CIB were significantly increased. It can be concluded that after a single intravenous injection of 40 mg/kg, sulfathiazole has a high tl/2β resulting in higher tissue concentrations. This half-life, which is higher than what is reported in the literature, is not influenced by the simultaneous presence of sulfamethazine. The tl/2β for sulfamethazine after a single intravenous injection of 80 mg/kg is comparable to the data from the literature and is not influenced by the presence of sulfathiazole. Sulfathiazole and SM were also administered simultaneously as an intramuscular injection to healthy pigs at a dosage of 40 and 80 mg/kg bodyweight. Pharmacokinetic experiments were conducted on three pigs. From this pharmacokinetic study it can be concluded that upon a single intramuscular administration of 40 mg/kg of ST and 80 mg/kg of SM the absolute bioavailability in pigs is 0.92 ± 0.04 for ST and l.01 ± 0.07 for SM. Six pigs received five intramuscular im) injections as a single dose of ST and SM every 24 h for five consecutive days for the residue study. The pigs were slaughtered at different times after the last dose was given and samples were taken from various tissues and organs. Concentrations were determined by a microbiological method and a HPTLC method. No edible tissue contained more than 100 μg/kg of the individual sulfonamides after 10 days of withdrawal. It means that adult animals which have a shorter half-life and thus lower tissue concentrations will certainly meet the economic community EC) maximum residue limits after a 10 days withdrawal period.

scholarly journals Studies on Metabolic Fate of 14C-RU44570: Placental Transfer, Transfer into Milk, Absorption Site and Repeated Dosing in Rats, and Metabolism in Rats and Dogs.

1994 ◽  
Vol 9 (6) ◽  
pp. 762-792
Author(s):  
Masashi HIRAYAMA ◽  
Tatsuo MANABE ◽  
Yoshinari HASEGAWA ◽  
Yoshiharu KATAMI ◽  
Katsumi UOHAMA ◽  
...  
Keyword(s):  
Placental Transfer ◽  
Metabolic Fate ◽  
Repeated Dosing
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