scholarly journals Pharmacokinetic studies of argipidine (MD-805) in rats. (II): Plasma level profile, distribution, metabolism and excretion after single or consecutive intravenous administration of argipidine.

1986 ◽  
Vol 1 (4) ◽  
pp. 377-395
Author(s):  
Seiu IIDA ◽  
Teiko KOMATSU ◽  
Masato IWAMOTO ◽  
Yoshiyuki FUJIMURA ◽  
Hiroshi NAKAI ◽  
...  
Keyword(s):  
Plasma Level ◽  
Intravenous Administration ◽  
Pharmacokinetic Studies ◽  
Profile Distribution ◽  
Level Profile

scholarly journals Studies on the metabolic fate of Benazepril hydrochloride in rats I: Plasma level profile, distribution, metabolism and excretion after single administration.

1992 ◽  
Vol 7 (3) ◽  
pp. 331-352
Author(s):  
Kazuo UNO ◽  
Satoru YAMAGAMI ◽  
Hiroka SHIGETOH ◽  
Yoshio ESUMI ◽  
Matsuo TAKAICHI ◽  
...  
Keyword(s):  
Plasma Level ◽  
Single Administration ◽  
Metabolic Fate ◽  
Profile Distribution ◽  
Level Profile

scholarly journals Simultaneous Determination of 5 Active Components of Periploca forrestii Schltr Extract in Rat Plasma by UPLC-MS and Its Application to Pharmacokinetic Studies in Normal and Adjuvant-Induced Arthritis Model Rats

2020 ◽  
Vol 15 (12) ◽  
pp. 1934578X2098143
Author(s):  
Hui Liu ◽  
Hao Chen ◽  
Xiaoli Qin ◽  
Xue Ma ◽  
Zipeng Gong ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chlorogenic Acid ◽  
Intravenous Administration ◽  
Area Under The Curve ◽  
Pharmacokinetic Studies ◽  
Active Components ◽  
Arthritis Model ◽  
Adjuvant Induced Arthritis ◽  
Neochlorogenic Acid

Periploca forrestii Schltr ( P. forrestii) is a herb used in traditional Chinese medicine for its anti-rheumatoid arthritis effect. The aim of this study was to compare the pharmacokinetic properties of the 5 active components of this plant: neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid C, and periplocin between normal rats and adjuvant-induced arthritis model rats. After the intravenous administration (177.78 mg/kg) of P. forrestii extract, samples were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry. Compared with normal rats, the area under the curve [(AUC)(0-t), AUC(0-∞)], mean residence time [(MRT)(0-t), MRT(0-∞)] of neochlorogenic acid-treated rats decreased significantly, and drug clearance (CL) and apparent volume of distribution (V) increased significantly; the V of chlorogenic acid-treated rats decreased significantly, and MRT(0-t) significantly increased; the AUC(0-t) and AUC(0-∞) of cryptochlorogenic acid-treated rats decreased significantly, and CL and V increased significantly; the AUC(0-t) and MRT(0-t) of isochlorogenic acid C-treated rats decreased significantly, and V increased significantly; the AUC(0-t) and AUC(0-∞) of periplocin-treated rats increased significantly, and MRT(0-t), MRT(0-∞), CL, and V decreased significantly in model rats. The disease condition of rheumatoid arthritis in rats had a significant effect on the in vivo pharmacokinetics of P. forrestii after the intravenous administration.

scholarly journals Pharmacokinetic studies of 1.ALPHA.,24(R)-(OH)2D3(TV-02)(5). Plasma level and excretion in beagle dogs.

1990 ◽  
Vol 5 (1) ◽  
pp. 63-69
Author(s):  
Tomohiro OHTA ◽  
Hirohide MIMURA ◽  
Masaru YAMAMOTO ◽  
Mamoru KIYOKI ◽  
Takeo OHBA ◽  
...  
Keyword(s):  
Plasma Level ◽  
Pharmacokinetic Studies ◽  
Beagle Dogs

scholarly journals Pharmacokinetic studies of 1.ALPHA., 24(R)-(OH)2D3(TV-02)(2). Plasma level, distribution, metabolism and excretion after repeated subcutaneous administration to rats.

1990 ◽  
Vol 5 (1) ◽  
pp. 25-37 ◽  
Author(s):  
Tomohiro OHTA ◽  
Masaru YAMAMOTO ◽  
Hirohide MIMURA ◽  
Takashi MATSUNAGA ◽  
Mamoru KIYOKI ◽  
...  
Keyword(s):  
Plasma Level ◽  
Subcutaneous Administration ◽  
Pharmacokinetic Studies

In Vivo Inhibition Of Thromboxane A2-Synthetase : Protective Effect Against Collagen And Arachidonate Infusion

1981 ◽  
Author(s):  
D Sincholle ◽  
C Fontaine ◽  
B Martin ◽  
C Bonne ◽  
P Regnault
Keyword(s):  
Blood Pressure ◽  
Plasma Level ◽  
Oral Treatment ◽  
Lethal Dose ◽  
Thromboxane A2 ◽  
Pharmacokinetic Studies ◽  
Antithrombotic Drugs ◽  
Thromboxane Synthetase ◽  
Derivatives Of

Rabbits and rats anaesthetised with thiopental were infused intravenously either with sodium arachidonate or collagen. Blood pressure and pneumogram were recorded and Thromboxane B2 (T×B2) plasma level was measured prior and after infusion. The aggregating agents elicited hypotension, respiratory break down and killed the animals. These events were associated with an increase in plasma T×B2 concentration. Intraperitoneal pretreatment of animals with derivatives of imidazole (1 -(3-hydroxy-1-oct enyl)-imidazole , chlorhydrat e (CBS6l2) and its nicotinic ester (CBS634) delayed toxic effects and death. In the standard conditions used in this study, the lethal dose of arachidonate in the rabbit was 8.4 t 1.0 mg/kg. This dose was increased to 21.6 ± 4.3 and 50.4 ± 8.0 when the animals were pretreated with CBS6l2 at the dose of respectively 12.5 mg/kg and 25 mg/kg. In the same way, the lethal dose of collagen in the rat was 0.5 ± 0.1 mg/kg in controls and 1.2 t 0.1 mg/kg after treatment with thromboxane-synthetase inhibitor (CBS634 = 25 mg/kg). The lethal dose of collagen was correlated to the concentration of T×B2 formed in the blood (controls : 4.4 ± 0.3 ; treated : 1.7 ± 0.2 ng/ml).Potential interest of these antithrombotic drugs could be strengthened by further pharmacokinetic studies after oral treatment actually in progress.

Plasma level profile of haloperidol in man following intramuscular administration

1974 ◽  
Vol 7 (2) ◽  
pp. 99-103 ◽  
Author(s):  
W. A. Cressman ◽  
J. R. Bianchine ◽  
V. B. Slotnick ◽  
P. C. Johnson ◽  
J. Plostnieks
Keyword(s):  
Plasma Level ◽  
Intramuscular Administration ◽  
Level Profile
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