Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat <i>in vivo</i> and <i>in vitro</i> data sets using a simplified physiologically based pharmacokinetic model

Mayu Yanagi; Yusuke Kamiya; Norie Murayama; Kaito Banju; Makiko Shimizu; Hiroshi Yamazaki

doi:10.2131/jts.46.391

Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat in vivo and in vitro data sets using a simplified physiologically based pharmacokinetic model

The Journal of Toxicological Sciences ◽

10.2131/jts.46.391 ◽

2021 ◽

Vol 46 (9) ◽

pp. 391-399

Author(s):

Mayu Yanagi ◽

Yusuke Kamiya ◽

Norie Murayama ◽

Kaito Banju ◽

Makiko Shimizu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Pyrrolizidine Alkaloid ◽

Metabolic Profiles ◽

Data Sets ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data

Drug Metabolism and Disposition ◽

10.1124/dmd.112.050294 ◽

2013 ◽

Vol 41 (4) ◽

pp. 744-753 ◽

Cited By ~ 15

Author(s):

Katherine L. Gill ◽

Michael Gertz ◽

J. Brian Houston ◽

Aleksandra Galetin

Keyword(s):

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Simulation of Toluene Kinetics in the Rat by a Physiologically Based Pharmacokinetic Model with Application of Biotransformation Parameters Derived Independently in Vitro and in Vivo

Toxicological Sciences ◽

10.1093/toxsci/32.2.260 ◽

1996 ◽

Vol 32 (2) ◽

pp. 260-268

Author(s):

JOOST DEJONGH ◽

BAS J. BLAAUBOER

Keyword(s):

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Development of a Physiologically Based Pharmacokinetic Model for Sinogliatin, a First-in-Class Glucokinase Activator, by Integrating Allometric Scaling, In Vitro to In Vivo Exploration and Steady-State Concentration–Mean Residence Time Methods: Mechanistic Understanding of its Pharmacokinetics

Clinical Pharmacokinetics ◽

10.1007/s40262-018-0631-z ◽

2018 ◽

Vol 57 (10) ◽

pp. 1307-1323 ◽

Cited By ~ 4

Author(s):

Ling Song ◽

Yi Zhang ◽

Ji Jiang ◽

Shuang Ren ◽

Li Chen ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Allometric Scaling ◽

Physiologically Based Pharmacokinetic Model ◽

Steady State Concentration ◽

Glucokinase Activator ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

State Concentration

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Combining an In Vitro Kinetic Model with a Physiologically-Based Pharmacokinetic Model to Assess the Potential In Vivo Fate of Polyvinyl Pyrrolidone-Vinyl Acetate Copolymers

Pharmaceutical Research ◽

10.1007/s11095-017-2305-1 ◽

2018 ◽

Vol 35 (4) ◽

Author(s):

Daniel S. Hsieh ◽

Liang Luo ◽

Yan Xu ◽

Joshua D. Engstrom ◽

Qi Gao

Keyword(s):

Kinetic Model ◽

Vinyl Acetate ◽

Pharmacokinetic Model ◽

Polyvinyl Pyrrolidone ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Biopharmaceutic In Vitro In Vivo Extrapolation (IVIV_E) Informed Physiologically-Based Pharmacokinetic Model of Ritonavir Norvir Tablet Absorption in Humans Under Fasted and Fed State Conditions

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.0c00043 ◽

2020 ◽

Vol 17 (7) ◽

pp. 2329-2344 ◽

Cited By ~ 4

Author(s):

Sumit Arora ◽

Amita Pansari ◽

Peter Kilford ◽

Masoud Jamei ◽

Iain Gardner ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Fed State ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation

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Physiologically Based Pharmacokinetic Model for Tetrachlorobenzyltoluenes in Rat: Comparison of in Vitro and in Vivo Metabolic Rates

Toxicological Sciences ◽

10.1093/toxsci/63.1.22 ◽

2001 ◽

Vol 63 (1) ◽

pp. 22-28 ◽

Cited By ~ 9

Author(s):

H. J. Kramer

Keyword(s):

Pharmacokinetic Model ◽

Metabolic Rates ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Development of a Physiologically Based Pharmacokinetic Model for the Rat Central Nervous System and Determination of an In Vitro–In Vivo Scaling Methodology for the Blood–Brain Barrier Permeability of Two Transporter Substrates, Morphine and Oxycodone

Journal of Pharmaceutical Sciences ◽

10.1002/jps.23266 ◽

2012 ◽

Vol 101 (11) ◽

pp. 4277-4292 ◽

Cited By ~ 35

Author(s):

Kathryn Ball ◽

François Bouzom ◽

Jean-Michel Scherrmann ◽

Bernard Walther ◽

Xavier Declèves

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Brain Barrier Permeability ◽

Physiologically Based

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The Novel In Vitro Method to Calculate Tissue-to-Plasma Partition Coefficient in Humans for Predicting Pharmacokinetic Profiles by Physiologically-Based Pharmacokinetic Model With High Predictability

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2020.04.002 ◽

2020 ◽

Vol 109 (7) ◽

pp. 2345-2355

Author(s):

Kei Mayumi ◽

Miho Tachibana ◽

Mei Yoshida ◽

Shuichi Ohnishi ◽

Takushi Kanazu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

The Novel ◽

Physiologically Based Pharmacokinetic Model ◽

In Vitro Method ◽

Physiologically Based Pharmacokinetic ◽

Pharmacokinetic Profiles ◽

Physiologically Based ◽

High Predictability ◽

Plasma Partition Coefficient

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Epimerization of moxalactam by albumin and simulation of in vivo epimerization by a physiologically based pharmacokinetic model

Chirality ◽

10.1002/(sici)1520-636x(1999)11:4<309::aid-chir8>3.0.co;2-g ◽

1999 ◽

Vol 11 (4) ◽

pp. 309-315 ◽

Cited By ~ 3

Author(s):

Takayoshi Yoshikawa ◽

Takayoshi Oguma ◽

Teruhisa Ichihashi ◽

Haruki Kinoshita ◽

Koichiro Hirano ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Evaluation of an integrated in vitro–in silico PBPK (physiologically based pharmacokinetic) model to provide estimates of human bioavailability

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2005.11.002 ◽

2006 ◽

Vol 308 (1-2) ◽

pp. 133-139 ◽

Cited By ~ 16

Author(s):

Hongliang Cai ◽

Chad Stoner ◽

Anita Reddy ◽

Sascha Freiwald ◽

Danielle Smith ◽

...

Keyword(s):

In Silico ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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