scholarly journals Effect of perinatal exposure to Bisphenol-A on DNA methylation and histone acetylation in cerebral cortex and hippocampus of postnatal male mice

2017 ◽  
Vol 42 (3) ◽  
pp. 281-289 ◽  
Author(s):  
Dhiraj Kumar ◽  
Mahendra Kumar Thakur
Keyword(s):  
Dna Methylation ◽  
Cerebral Cortex ◽  
Bisphenol A ◽  
Histone Acetylation ◽  
Perinatal Exposure ◽  
Male Mice

scholarly journals Multigenerational and transgenerational impact of paternal bisphenol A exposure on male fertility in a mouse model

2020 ◽  
Vol 35 (8) ◽  
pp. 1740-1752 ◽  
Author(s):  
Md Saidur Rahman ◽  
Won-Ki Pang ◽  
Do-Yeal Ryu ◽  
Yoo-Jin Park ◽  
Myung-Geol Pang
Keyword(s):  
Dna Methylation ◽  
Bisphenol A ◽  
Large Scale ◽  
Corn Oil ◽  
Sperm Count ◽  
Future Generations ◽  
High Dose ◽  
Male Mice ◽  
Paternal Exposure ◽  
Methylation Patterns

Abstract STUDY QUESTION How does paternal exposure to bisphenol A (BPA) affect the fertility of male offspring in mice in future generations? SUMMARY ANSWER Paternal exposure to BPA adversely affects spermatogenesis, several important sperm functions and DNA methylation patterns in spermatozoa, which have both multigenerational (in F0 and F1) and partial transgenerational (mainly noticed in F2, but F3) impacts on the fertility of the offspring. WHAT IS KNOWN ALREADY BPA, a synthetic endocrine disruptor, is used extensively to manufacture polycarbonate plastics and epoxy resins. Growing evidence suggests that exposure to BPA during the developmental stages results in atypical reproductive phenotypes that could persist for generations to come. STUDY DESIGN, SIZE, DURATION CD-1 male mice (F0) were treated with BPA (5 or 50 mg/kg body weight per day (bw/day)) or ethinylestradiol (EE) (0.4 μg/kg bw/day) for 6 weeks. Control mice were treated with vehicle (corn oil) only. The treated male mice were bred with untreated female mice to produce first filial generation (F1 offspring). The F2 and F3 offspring were produced similarly, without further exposure to BPA. PARTICIPANTS/MATERIALS, SETTING, METHODS Histological changes in the testis along with functional, biochemical and epigenetic (DNA methylation) properties of spermatozoa were investigated. Subsequently, each parameter of the F0–F3 generations was compared between BPA-treated mice and control mice. MAIN RESULTS AND THE ROLE OF CHANCE Paternal BPA exposure disrupted spermatogenesis by decreasing the size and number of testicular seminiferous epithelial cells, which eventually led to a decline in the total sperm count of F0–F2 offspring (P < 0.05). We further showed that a high BPA dose decreased sperm motility in F0–F2 males by mediating the overproduction of reactive oxygen species (F0–F1) and decreasing intracellular ATP (F0–F2) in spermatozoa (P < 0.05). These changes in spermatozoa were associated with altered global DNA methylation patterns in the spermatozoa of F0–F3 males (P < 0.05). Furthermore, we noticed that BPA compromised sperm fertility in mice from the F0–F2 (in the both dose groups) and F3 generations (in the high-dose group only). The overall reproductive toxicity of BPA was equivalent to or higher (high dose) than that of the tested dose of EE. LARGE SCALE DATA N/A. LIMITATIONS, REASONS FOR CAUTION Further research is required to determine the variables (e.g. lowest BPA dose) that are capable of producing changes in sperm function and fertility in future generations. WIDER IMPLICATIONS OF THE FINDINGS These results may shed light on how occupational exposure to BPA can affect offspring fertility in humans. STUDY FUNDING/COMPETING INTEREST(S) This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (Grant No. NRF-2018R1A6A1A03025159). M.S.R. was supported by Korea Research Fellowship Program through the NRF funded by the Ministry of Science and ICT (Grant No. 2017H1D3A1A02013844). There are no competing interests.

Perinatal exposure to bisphenol-A inhibits synaptogenesis and affects the synaptic morphological development in offspring male mice

Chemosphere ◽  
2013 ◽  
Vol 91 (8) ◽  
pp. 1073-1081 ◽  
Author(s):  
Xiaohong Xu ◽  
Lingdan Xie ◽  
Xing Hong ◽  
Qin Ruan ◽  
Hongfei Lu ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Morphological Development ◽  
Perinatal Exposure ◽  
Male Mice

scholarly journals Perinatal exposure to low-dose bisphenol A disrupts learning/memory and DNA methylation of estrogen receptor alpha in the hippocampus

2016 ◽  
Vol 5 (3) ◽  
pp. 828-835 ◽  
Author(s):  
Huailong Chang ◽  
Mu Wang ◽  
Wei Xia ◽  
Tian Chen ◽  
Wenqian Huo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Estrogen Receptor ◽  
Bisphenol A ◽  
Brain Development ◽  
Estrogen Receptor Alpha ◽  
Low Dose ◽  
Perinatal Exposure ◽  
Developmental Exposure ◽  
Receptor Alpha ◽  
And Behaviors

Developmental exposure to bisphenol A (BPA) has been indicated to pose long-lasting effects on brain development and behaviors in adulthood.

Effects of perinatal exposure to bisphenol A and di(2-ethylhexyl)-phthalate on gonadal development of male mice

2012 ◽  
Vol 19 (7) ◽  
pp. 2515-2527 ◽  
Author(s):  
Wei Xi ◽  
H. T. Wan ◽  
Y. G. Zhao ◽  
M. H. Wong ◽  
John P. Giesy ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Gonadal Development ◽  
Perinatal Exposure ◽  
Male Mice ◽  
Ethylhexyl Phthalate

Liver DNA methylation analysis in adult female C57BL/6JxFVB mice following perinatal exposure to bisphenol A

2015 ◽  
Vol 232 (1) ◽  
pp. 293-300 ◽  
Author(s):  
J.C.J. van Esterik ◽  
A.P. Vitins ◽  
H.M. Hodemaekers ◽  
J.H. Kamstra ◽  
J. Legler ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Bisphenol A ◽  
Adult Female ◽  
Perinatal Exposure ◽  
Methylation Analysis ◽  
Dna Methylation Analysis

DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers

2016 ◽  
Vol 373 (2) ◽  
pp. 185-192 ◽  
Author(s):  
Ching-Yu Yen ◽  
Hurng-Wern Huang ◽  
Chih-Wen Shu ◽  
Ming-Feng Hou ◽  
Shyng-Shiou F. Yuan ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Histone Acetylation ◽  
Therapeutic Approach ◽  
Epigenetic Modifications

scholarly journals Perinatal Exposure to Bisphenol A Increases Adult Mammary Gland Progesterone Response and Cell Number

2011 ◽  
Vol 25 (11) ◽  
pp. 1915-1923 ◽  
Author(s):  
Ayyakkannu Ayyanan ◽  
Ouahiba Laribi ◽  
Sonia Schuepbach-Mallepell ◽  
Christina Schrick ◽  
Maria Gutierrez ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Bisphenol A ◽  
Cell Number ◽  
Perinatal Exposure

scholarly journals Effects of Perinatal Exposure to Bisphenol A on Brain Neurotransmitters in Female Rat Offspring

2006 ◽  
Vol 44 (3) ◽  
pp. 510-524 ◽  
Author(s):  
Takeshi HONMA ◽  
Muneyuki MIYAGAWA ◽  
Megumi SUDA ◽  
Rui-Sheng WANG ◽  
Kenichi KOBAYASHI ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Perinatal Exposure ◽  
Female Rat ◽  
Rat Offspring ◽  
Brain Neurotransmitters
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