scholarly journals Pulmonary toxicity screening of triclosan in rats after intratracheal instillation

2013 ◽  
Vol 38 (3) ◽  
pp. 471-475 ◽  
Author(s):  
Jung-Taek Kwon ◽  
Young-Su Yang ◽  
Min-Sung Kang ◽  
Gyun-Baek Seo ◽  
Dong Hun Lee ◽  
...  
Keyword(s):  
Pulmonary Toxicity ◽  
Intratracheal Instillation ◽  
Toxicity Screening

scholarly journals A 104-week pulmonary toxicity assessment of long and short single-wall carbon nanotubes after a single intratracheal instillation in rats

2017 ◽  
Vol 29 (11) ◽  
pp. 471-482 ◽  
Author(s):  
Kazumasa Honda ◽  
Masato Naya ◽  
Hiroshi Takehara ◽  
Hiromichi Kataura ◽  
Katsuhide Fujita ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Pulmonary Toxicity ◽  
Intratracheal Instillation ◽  
Toxicity Assessment ◽  
Single Wall Carbon Nanotubes ◽  
Single Wall Carbon

scholarly journals Comparison of Genotoxicity and Pulmonary Toxicity Study of Modified SiO2 Nanomaterials

2021 ◽  
Vol 11 (24) ◽  
pp. 11990
Author(s):  
Yng-Tay Chen ◽  
Po-Yi Lue ◽  
Po-Wei Chen ◽  
Pin-Ju Chueh ◽  
Fuu-Jen Tsai ◽  
...  
Keyword(s):  
Pulmonary Toxicity ◽  
Intratracheal Instillation ◽  
Lavage Fluid ◽  
Solid Content ◽  
Inhalation Toxicity ◽  
Nano Sio2 ◽  
Negative Results ◽  
Significant Difference ◽  
Chromosomal Aberration Test ◽  
Surface Modified

Surface-modified nano-SiO2 is a common additive in many products. However, the safety of nano-SiO2 products under various modifications is still unclear. In this study, we investigated the genotoxicity and acute pulmonary toxicity of nano-SiO2 with or without modification. The samples used in this study included: sample A (SA, 55.16 nm, 411.3 mg/mL), modified sample A (mSA, 82.29 nm, 37.7 mg/mL), sample B (SB, 22 nm, 358.0 mg/mL), and modified sample B (mSB, 86.64 nm, 37.7 mg/mL). In the genotoxicity study, we conducted an Ames test, chromosomal aberration test (CA), and a micronucleus (MN) test. The SA, mSA, and mSB groups showed negative results in all these genotoxicity tests. Only SB showed a weakly positive reaction in these assays, but the genotoxicity could be reversed after S9 metabolism or modification. In the acute pulmonary toxicity test, the rats were given an intratracheal instillation (IT) (0.5 mL/kg) of diluted samples and sacrificed after 1 or 14 days. The mortality rate, number of leukocytes and cytokines of TNF-α in the bronchoalveolar lavage fluid (BALF), and the pathology in the lungs were determined. The results revealed that mSA posed acute toxicity in rats. After modification, the pulmonary toxicity was increased in mSA but decreased in mSB on Day 1, and no significant difference was observed on Day 14. In conclusion, there was no observed genotoxicity in either SA or SB, while mSA posed acute inhalation toxicity to rats that decreased in mSB after modification. This indicates that the decrease in pH level in SA and decrease in the solid content in SB are considered after the trifluorosilane surface-modified amorphous nano-silica.

scholarly journals PULMONARY TOXICITY OF SIMULATED LUNAR AND MARTIAN DUSTS IN MICE: I. HISTOPATHOLOGY 7 AND 90 DAYS AFTER INTRATRACHEAL INSTILLATION

2002 ◽  
Vol 14 (9) ◽  
pp. 901-916 ◽  
Author(s):  
Chiu-Wing Lam ◽  
John T. James ◽  
Richard McCluskey ◽  
Shawn Cowper ◽  
John Balis ◽  
...  
Keyword(s):  
Pulmonary Toxicity ◽  
Intratracheal Instillation

Pulmonary toxicity of well-dispersed multi-wall carbon nanotubes following inhalation and intratracheal instillation

2011 ◽  
Vol 6 (6) ◽  
pp. 587-599 ◽  
Author(s):  
Yasuo Morimoto ◽  
Masami Hirohashi ◽  
Akira Ogami ◽  
Takako Oyabu ◽  
Toshihiko Myojo ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Pulmonary Toxicity ◽  
Intratracheal Instillation ◽  
Multi Wall Carbon Nanotubes

scholarly journals Long‐term observation of pulmonary toxicity of toner with external additives following a single intratracheal instillation in rats

2020 ◽  
Vol 62 (1) ◽  
Author(s):  
Taisuke Tomonaga ◽  
Hiroto Izumi ◽  
Yukiko Yoshiura ◽  
Takashi Marui ◽  
Ke‐Yong Wang ◽  
...  
Keyword(s):  
Pulmonary Toxicity ◽  
Intratracheal Instillation ◽  
Long Term Observation

scholarly journals Significance of Intratracheal Instillation Tests for the Screening of Pulmonary Toxicity of Nanomaterials

2017 ◽  
Vol 39 (2) ◽  
pp. 123-132 ◽  
Author(s):  
Yasuo MORIMOTO ◽  
Hiroto IZUMI ◽  
Yukiko YOSHIURA ◽  
Yuri FUJISAWA ◽  
Katsuhide FUJITA
Keyword(s):  
Pulmonary Toxicity ◽  
Intratracheal Instillation

scholarly journals Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories

2015 ◽  
Vol 85 ◽  
pp. 84-95 ◽  
Author(s):  
Nicklas Raun Jacobsen ◽  
Tobias Stoeger ◽  
Sybille van den Brule ◽  
Anne Thoustrup Saber ◽  
Andrea Beyerle ◽  
...  
Keyword(s):  
Zno Nanoparticles ◽  
Pulmonary Toxicity ◽  
Intratracheal Instillation
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