scholarly journals Embryonic mortality and intrauterine growth retardation (IUGR) associated with placental alterations in pregnant rats treated with methyl methanesulfonate (MMS) at the peri-implantation stage

2008 ◽  
Vol 33 (5) ◽  
pp. 585-598 ◽  
Author(s):  
Ryohei Yokoi ◽  
Morimichi Hayashi ◽  
Toru Tamura ◽  
Kazuo Kobayashi ◽  
Junji Kuroda ◽  
...  
Keyword(s):  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Embryonic Mortality ◽  
Methyl Methanesulfonate ◽  
Pregnant Rats ◽  
Intrauterine Growth

scholarly journals Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study

2005 ◽  
Vol 16 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Daniela Atili Brandini ◽  
Miguel Angel Sala ◽  
Ruberval Armando Lopes ◽  
Marisa Semprini ◽  
Mary Garcia Duarte Contrera
Keyword(s):  
Cigarette Smoke ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Pregnant Rats ◽  
Rat Fetus ◽  
Meckel's Cartilage ◽  
Intrauterine Growth ◽  
Meckel’S Cartilage ◽  
Female Wistar Rats ◽  
Experimental Group

The purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel's cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage.

scholarly journals Experimental investigation of the lipin gravidoprotective action in the model of placental disfunction caused by oxidative stress

2014 ◽  
Vol 12 (2) ◽  
pp. 59-64
Author(s):  
Olesya Viktorovna Kudina
Keyword(s):  
Oxidative Stress ◽  
Experimental Investigation ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Morphological Changes ◽  
Placental Insufficiency ◽  
Pronounced Effect ◽  
Pregnant Rats ◽  
Reference Drug ◽  
Intrauterine Growth

In the model of placental insufficiency caused by tetrachlormethane during organogenesis in rats, a pronounced effect of the gravidoprotective drug lipin was found assessed in their ability to prevent intrauterine growth retardation of rats and to normalize the morphological changes in the liver, kidney and placenta of pregnant rats. The drug lipin exceeds the reference drug essentiale on the sum of these indicators.

Placental Alterations, Intrauterine Growth Retardation and Teratogenicity Associated with Enalapril Use in Pregnant Rats

Neonatology ◽  
1992 ◽  
Vol 61 (2) ◽  
pp. 124-130 ◽  
Author(s):  
Gloria Valdés ◽  
Daniela Marinovic ◽  
Cristián Falcón ◽  
Rodrigo Chuaqui ◽  
Ignacio Duarte
Keyword(s):  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Pregnant Rats ◽  
Intrauterine Growth

Imbalance in the system L-arginin-NO in pathogenesis of obstetric complications and intrauterine growth retardation (Literature review)

2016 ◽  
pp. 43-47
Author(s):  
O.V. Basystyi ◽  
Keyword(s):  
Nitric Oxide ◽  
Literature Review ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Obstetric Complications ◽  
Pathogenetic Role ◽  
Intrauterine Growth ◽  
System L ◽  
Nitric Oxide Deficiency

The data of domestic and foreign literature on etiology, pathogenesis and intrauterine growth retardation diagnosis are presented in the paper. It highlights pathogenetic role of nitric oxide deficiency in case of obstetric complications and intrauterine growth retardation. Key words: intrauterine growth retardation (IUGR), system L-arginin–NO, obstetric complications.

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