scholarly journals Usefulness of HepaRG cells in the mitochondrial function assay for the estimation of potential risk of idiosyncratic drug-induced liver injury

2020 ◽  
Vol 7 (3) ◽  
pp. 153-160
Author(s):  
Keisuke Goda ◽  
Taku Masuyama
Keyword(s):  
Liver Injury ◽  
Mitochondrial Function ◽  
Potential Risk ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Heparg Cells

scholarly journals Novel biomarkers for potential risk stratification of drug induced liver injury (DILI)

Medicine ◽  
2019 ◽  
Vol 98 (50) ◽  
pp. e18322 ◽  
Author(s):  
Mohammed Ibn-Mas’ud Danjuma ◽  
Jamal Sajid ◽  
Haajra Fatima ◽  
Abdel-Naser Elzouki
Keyword(s):  
Liver Injury ◽  
Risk Stratification ◽  
Potential Risk ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Novel Biomarkers

A modified multiparametric assay using HepaRG cells for predicting the degree of drug-induced liver injury risk

2016 ◽  
Vol 37 (3) ◽  
pp. 382-390 ◽  
Author(s):  
Takafumi Tomida ◽  
Hayao Okamura ◽  
Tsuyoshi Yokoi ◽  
Yoshihiro Konno
Keyword(s):  
Liver Injury ◽  
Injury Risk ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Heparg Cells

The in silico identification of human bile salt export pump (ABCB11) inhibitors associated with cholestatic drug-induced liver injury

2017 ◽  
Vol 13 (2) ◽  
pp. 417-424 ◽  
Author(s):  
Lili Xi ◽  
Jia Yao ◽  
Yuhui Wei ◽  
Xin'an Wu ◽  
Xiaojun Yao ◽  
...  
Keyword(s):  
Liver Injury ◽  
Potential Risk ◽  
Screening Tools ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Human Bile ◽  
Drug Induced Liver Injury ◽  
In Silico Identification ◽  
Integrated Screening ◽  
Pharmacophore Models

The RF and pharmacophore models can be considered as integrated screening tools to indicate the potential risk of cholestatic DILI.

Multiparametric assay using HepaRG cells for predicting drug-induced liver injury

2015 ◽  
Vol 236 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Takafumi Tomida ◽  
Hayao Okamura ◽  
Masahiro Satsukawa ◽  
Tsuyoshi Yokoi ◽  
Yoshihiro Konno
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Heparg Cells

scholarly journals Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

Hepatology ◽  
2014 ◽  
Vol 60 (3) ◽  
pp. 1015-1022 ◽  
Author(s):  
Michael D. Aleo ◽  
Yi Luo ◽  
Rachel Swiss ◽  
Paul D. Bonin ◽  
David M. Potter ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Mitochondrial Function ◽  
Injury Severity ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Dual Inhibition

scholarly journals Design and synthesis of acetaminophen probe APAP-P1 for identification of the toxicity targets thioredoxin reductase-1 in HepaRG cells

RSC Advances ◽  
2019 ◽  
Vol 9 (27) ◽  
pp. 15224-15228
Author(s):  
Shan Wang ◽  
Yu Tian ◽  
Shan Lu ◽  
Ruiying Wang ◽  
Hai Shang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Drug Administration ◽  
Drug Withdrawal ◽  
Food And Drug Administration ◽  
Thioredoxin Reductase ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Design And Synthesis ◽  
Thioredoxin Reductase 1 ◽  
Heparg Cells

Drug-induced liver injury is one of the main causes of drug non-approval and drug withdrawal by the Food and Drug Administration (FDA).

Leberschaden unter oraler Antikoagulation, Statin- und ACE-Hemmertherapie

Praxis ◽  
2010 ◽  
Vol 99 (21) ◽  
pp. 1259-1265 ◽  
Author(s):  
Bruggisser ◽  
Terraciano ◽  
Rätz Bravo ◽  
Haschke
Keyword(s):  
Liver Injury ◽  
Wird Eine ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Ein 71-jähriger Patient stellt sich mit Epistaxis und ikterischen Skleren auf der Notfallstation vor. Der Patient steht unter einer Therapie mit Phenprocoumon, Atorvastatin und Perindopril. Anamnestisch besteht ein langjähriger Alkoholabusus. Laborchemisch werden massiv erhöhte Leberwerte (ALAT, Bilirubin) gesehen. Der INR ist unter oraler Antikoagulation und bei akuter Leberinsuffizienz >12. Die weiterführenden Abklärungen schliessen eine Virushepatitis und eine Autoimmunhepatitis aus. Nachdem eine Leberbiopsie durchgeführt werden kann, wird eine medikamentös-toxische Hepatitis, ausgelöst durch die Komedikation von Atorvastatin, Phenprocoumon und Perindopril bei durch Alkohol bereits vorgeschädigter Leber diagnostiziert. Epidemiologie, Pathophysiologie und Klink der medikamentös induzierten Leberschäden (drug induced liver injury, DILI), speziell von Coumarinen, Statinen und ACE-Hemmern werden im Anschluss an den Fallbericht diskutiert.

Drug-induced liver injury network (DILIN)

Hepatology ◽  
2004 ◽  
Vol 40 (4) ◽  
pp. 773-773 ◽  
Author(s):  
Jay H. Hoofnagle
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury
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