The in silico identification of human bile salt export pump (ABCB11) inhibitors associated with cholestatic drug-induced liver injury

2017 ◽  
Vol 13 (2) ◽  
pp. 417-424 ◽  
Author(s):  
Lili Xi ◽  
Jia Yao ◽  
Yuhui Wei ◽  
Xin'an Wu ◽  
Xiaojun Yao ◽  
...  
Keyword(s):  
Liver Injury ◽  
Potential Risk ◽  
Screening Tools ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Human Bile ◽  
Drug Induced Liver Injury ◽  
In Silico Identification ◽  
Integrated Screening ◽  
Pharmacophore Models

The RF and pharmacophore models can be considered as integrated screening tools to indicate the potential risk of cholestatic DILI.

scholarly journals Novel biomarkers for potential risk stratification of drug induced liver injury (DILI)

Medicine ◽  
2019 ◽  
Vol 98 (50) ◽  
pp. e18322 ◽  
Author(s):  
Mohammed Ibn-Mas’ud Danjuma ◽  
Jamal Sajid ◽  
Haajra Fatima ◽  
Abdel-Naser Elzouki
Keyword(s):  
Liver Injury ◽  
Risk Stratification ◽  
Potential Risk ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Novel Biomarkers

scholarly journals Cholestatic Drug Induced Liver Injury: A Function of Bile Salt Export Pump Inhibition and Farnesoid X Receptor Antagonism

2018 ◽  
Vol 4 (3) ◽  
pp. 265-279 ◽  
Author(s):  
Jonathan P. Jackson ◽  
Kimberly M. Freeman ◽  
Robert L. St. Claire ◽  
Chris B. Black ◽  
Kenneth R. Brouwer
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Farnesoid X Receptor ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Receptor Antagonism ◽  
Drug Induced Liver Injury

Role of chemical structures and the 1331T>C bile salt export pump polymorphism in idiosyncratic drug-induced liver injury

2013 ◽  
Vol 33 (9) ◽  
pp. 1378-1385 ◽  
Author(s):  
Eugenia Ulzurrun ◽  
Camilla Stephens ◽  
Esperanza Crespo ◽  
Francisco Ruiz-Cabello ◽  
Julia Ruiz-Nuñez ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Chemical Structures

Evaluation of the relationship between inhibition of the bile salt export pump in vitro and risk of drug-induced liver injury in man

Toxicology ◽  
2010 ◽  
Vol 278 (3) ◽  
pp. 356
Author(s):  
Sarah Dawson ◽  
Simone Stahl ◽  
Jane Barber ◽  
Claire Summers ◽  
Nikki Paul ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
The Relationship

In Silico Identification of Proteins Associated with Drug-induced Liver Injury Based on the Prediction of Drug-target Interactions

2017 ◽  
Vol 36 (7) ◽  
pp. 1600142 ◽  
Author(s):  
Sergey Ivanov ◽  
Maxim Semin ◽  
Alexey Lagunin ◽  
Dmitry Filimonov ◽  
Vladimir Poroikov
Keyword(s):  
Liver Injury ◽  
In Silico ◽  
Drug Target ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
In Silico Identification

scholarly journals Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

Hepatology ◽  
2014 ◽  
Vol 60 (3) ◽  
pp. 1015-1022 ◽  
Author(s):  
Michael D. Aleo ◽  
Yi Luo ◽  
Rachel Swiss ◽  
Paul D. Bonin ◽  
David M. Potter ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Mitochondrial Function ◽  
Injury Severity ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Dual Inhibition
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