scholarly journals Sulforaphane displays the growth inhibition, cytotoxicity and enhancement of retinoic acid-induced superoxide-generating activity in human monoblastic U937 cells

2019 ◽  
Vol 6 (8) ◽  
pp. 319-325 ◽  
Author(s):  
Sumiko Akiyoshi ◽  
Hidehiko Kikuchi ◽  
Futoshi Kuribayashi ◽  
Harishkumar Madhyastha ◽  
Hisanori Minami
Keyword(s):  
Retinoic Acid ◽  
Growth Inhibition ◽  
U937 Cells

scholarly journals Orphan Receptor COUP-TF Is Required for Induction of Retinoic Acid Receptor β, Growth Inhibition, and Apoptosis by Retinoic Acid in Cancer Cells

2000 ◽  
Vol 20 (3) ◽  
pp. 957-970 ◽  
Author(s):  
Bingzhen Lin ◽  
Guo-quan Chen ◽  
Dongmei Xiao ◽  
Siva Kumar Kolluri ◽  
Xihua Cao ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Retinoic Acid Receptor ◽  
Critical Role ◽  
Orphan Receptor ◽  
Dependent Manner ◽  
Anticancer Activities ◽  
Transient Transfection Assay ◽  
Acid Receptor

ABSTRACT Retinoic acid receptor β (RARβ) plays a critical role in mediating the anticancer effects of retinoids. Expression of RARβ is highly induced by retinoic acid (RA) through a RA response element (βRARE) that is activated by heterodimers of RARs and retinoid X receptors (RXRs). However, RARβ induction is often lost in cancer cells despite expression of RARs and RXRs. In this study, we provide evidence that orphan receptor COUP-TF is required for induction of RARβ expression, growth inhibition, and apoptosis by RA in cancer cells. Expression of COUP-TF correlates with RARβ induction in a variety of cancer cell lines. In addition, stable expression of COUP-TF in COUP-TF-negative cancer cells restores induction of RARβ expression, growth inhibition, and apoptosis by RA, whereas inhibition of COUP-TF by expression of COUP-TF antisense RNA represses the RA effects. In a transient transfection assay, COUP-TF strongly induced transcriptional activity of the RARβ promoter in a RA- and RARα-dependent manner. By mutation analysis, we demonstrate that the effect of COUP-TF requires its binding to a DR-8 element present in the RARβ promoter. The binding of COUP-TF to the DR-8 element synergistically increases the RA-dependent RARα transactivation function by enhancing the interaction of RARα with its coactivator CREB binding protein. These results demonstrate that COUP-TF, by serving as an accessory protein for RARα to induce RARβ expression, plays a critical role in regulating the anticancer activities of retinoids.

scholarly journals Correction to: Role of mitochondria and cardiolipins in growth inhibition of breast cancer cells by retinoic acid

2019 ◽  
Vol 38 (1) ◽  
Author(s):  
Mineko Terao ◽  
Laura Goracci ◽  
Valentina Celestini ◽  
Mami Kurosaki ◽  
Marco Bolis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Original Publication

In the original publication of this article [1], the images of Figs. 4 and 5 were exchanged and the legends of the two figures did not correspond due to a typesetting error.

Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells

Blood ◽  
2015 ◽  
Vol 125 (22) ◽  
pp. 3455-3465 ◽  
Author(s):  
Maria Paola Martelli ◽  
Ilaria Gionfriddo ◽  
Federica Mezzasoma ◽  
Francesca Milano ◽  
Sara Pierangeli ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Cell Growth ◽  
Growth Inhibition ◽  
Arsenic Trioxide ◽  
Cell Growth Inhibition ◽  
Protein Levels ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Key Points

Key Points ATRA and ATO affect NPM1 protein levels in AML cells and induce cell growth inhibition and apoptosis. AML cells with mutated NPM1 respond to ATRA/ATO, and this might be exploited therapeutically.

Retinoic acid receptor α mediates growth inhibition by retinoids in rat pancreatic carcinoma DSL-6A/C1 cells

1998 ◽  
Vol 114 ◽  
pp. A444-A445
Author(s):  
F.H. Brembeck ◽  
A. Kaiser ◽  
K. Detjen ◽  
H. Hotz ◽  
T. Foitzik ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Growth Inhibition ◽  
Pancreatic Carcinoma ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Α
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