scholarly journals Genotoxicity evaluation of oil prepared from the internal organs of the Japanese giant scallop (Patinopecten yessoensis)

2019 ◽  
Vol 6 (4) ◽  
pp. 137-143
Author(s):  
Koki Sugimoto ◽  
Ryota Hosomi ◽  
Kenji Fukunaga ◽  
Takaki Shimono ◽  
Seiji Kanda ◽  
...  
Keyword(s):  
Internal Organs ◽  
Patinopecten Yessoensis

scholarly journals Repeated 28-day and 13-week dose toxicity studies of oils prepared from the internal organs of the Japanese giant scallop (Patinopecten yessoensis) in rats

2020 ◽  
Vol 7 (4) ◽  
pp. 177-188
Author(s):  
Koki Sugimoto ◽  
Eito Shimizu ◽  
Nozomi Hagihara ◽  
Ryota Hosomi ◽  
Kenji Fukunaga ◽  
...  
Keyword(s):  
Internal Organs ◽  
Patinopecten Yessoensis ◽  
Toxicity Studies

scholarly journals Single and Repeated Dose 28-Day and 13-Week Toxicity Studies of Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis) in Mice

Foods ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 691
Author(s):  
Koki Sugimoto ◽  
Toshifumi Tanizaki ◽  
Eito Shimizu ◽  
Ryota Hosomi ◽  
Kenji Fukunaga ◽  
...  
Keyword(s):  
Oral Dose ◽  
Clinical Signs ◽  
Toxicity Study ◽  
Toxic Substances ◽  
Food Ingredient ◽  
Internal Organs ◽  
Experimental Conditions ◽  
Patinopecten Yessoensis ◽  
Food Ingredients ◽  
Toxicity Studies

Internal organs of discarded scallops are rich in omega-3 polyunsaturated fatty acids, but it is not used as a food ingredient due to the presence of toxic substances. Recently, our research team prepared high-quality scallop oil (SCO) from the internal organs of the Japanese giant scallop (Patinopecten yessoensis), in which cadmium and diarrhetic shellfish toxin are below regulated levels. In this study, SCO was prepared from the internal organs of scallops obtained from Mutsu and Uchiura bays in Japan, and was referred to as SCO-M (scallop oil from Mutsu bay) and SCO-U (scallop oil from Uchiura bay), respectively. Acute and subacute toxicity studies were performed to assess the safety of the prepared SCO. In acute toxicity study, mice were orally administered SCO-M and SCO-U at a single dose of 5,000 mg/kg body weight. In a 28-day repeated oral dose toxicity study, the mice were fed diets containing 1% and 5% SCO-M and SCO-U; and in a 13-week repeated oral dose toxicity study, the mice were fed 5% SCO-M and SCO-U. There were no toxicologically significant changes in clinical signs, hematology, blood chemistry, and organ weights at any dose during the experiment. Therefore, it was concluded that SCO-M and SCO-U are safe for use as food ingredients under the experimental conditions of this study.

scholarly journals Dietary Phospholipids Prepared From Scallop Internal Organs Attenuate the Serum and Liver Cholesterol Contents by Enhancing the Expression of Cholesterol Hydroxylase in the Liver of Mice

2021 ◽  
Vol 8 ◽  
Author(s):  
Koki Sugimoto ◽  
Ryota Hosomi ◽  
Munehiro Yoshida ◽  
Kenji Fukunaga
Keyword(s):  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Farnesoid X Receptor ◽  
Liver Cholesterol ◽  
Internal Organs ◽  
Patinopecten Yessoensis ◽  
Cholesterol Lowering ◽  
Lowering Effect ◽  
Fa Composition ◽  
Cholesterol Lowering Effect

In this study, we successfully prepared scallop oil (SCO), which contains high levels of phospholipids (PL) and eicosapentaenoic acid (EPA), from the internal organs of the Japanese giant scallop (Patinopecten yessoensis), one of the most important underutilized fishery resources in Japan. The intake of SCO lowers the serum and liver cholesterol contents in mice; however, whether the fatty acids (FA) composition or PL of SCO exhibits any cholesterol-lowering effect remains unknown. To elucidate whether the cholesterol-lowering function is due to FA composition or PL of SCO, and investigate the cholesterol-lowering mechanism by SCO, in the present study, mice were fed SCO's PL fraction (SCO-PL), triglyceride (TG)-type oil with almost the same FA composition as SCO-PL, called SCO's TG fraction (SCO-TG), soybean oil (SOY-TG), and soybean's PL fraction (SOY-PL). Male C57BL/6J mice (5-week-old) were fed high-fat and cholesterol diets containing 3% (w/w) experimental oils (SOY-TG, SOY-PL, SCO-TG, and SCO-PL) for 28 days. The SCO-PL diet significantly decreased the serum and liver cholesterol contents compared with the SOY-TG diet, but the intake of SOY-PL and SCO-TG did not show this effect. This result indicated that the serum and liver cholesterol-lowering effect observed in the SCO intake group was due to the effect of SCO-PL. The cholesterol-lowering effect of SCO-PL was in part related to the promotion of liver cholesterol 7α-hydroxylase (CYP7A1) expression, which is the rate-limiting enzyme for bile acid synthesis. In contrast, the expression levels of the ileum farnesoid X receptor (Fxr) and fibroblast growth factor 15 (Fgf15), which inhibit the expression of liver CYP7A1, were significantly reduced in the SCO-PL group than the SOY-TG group. From these results, the increase in the liver CYP7A1 expression by dietary SCO-PL was in part through the reduction of the ileum Fxr/Fgf15 regulatory pathway. Therefore, this study showed that SCO-PL may be a health-promoting component as it lowers the serum and liver cholesterol contents by increasing the liver CYP7A1 expression, which is not seen in SOY-PL and SCO-TG.

Numerical and experimental investigation on internal membrane pressure wave inside sealed structure

2013 ◽  
Vol 61 (3) ◽  
pp. 613-621 ◽  
Author(s):  
W. Barnat
Keyword(s):  
Experimental Investigation ◽  
Pressure Wave ◽  
Pressure Increase ◽  
Internal Organs ◽  
Pressure Impulse ◽  
Internal Membrane ◽  
Contaminated Area

Abstract The article presents an approach to modeling the internal membrane pressure wave inside a sealed structure. During an explosion near a vehicle when a pressure wave reaches a hull, a pressure wave inside arises due to the hull’s bottom and the deformation of sides. They act like the piston - membrane. This membrane transfers the pressure impulse into the vehicle’s interior. A pressure increase causes the damage of internal organs or even death of occupants. In case of an armor penetration the pressure increase may be even larger. One of basic methods to protect a crew is to open hatches. However, such a method cannot be used in a contaminated area.

Rheumatoid Arthritis: History, Stages, Epidemiology, Pathogenesis, Diagnosis and Treatment

2017 ◽  
Vol 9 (02) ◽  
Author(s):  
Abeer Fauzi Al-Rubaye ◽  
Mohanad Jawad Kadhim ◽  
Imad Hadi Hameed
Keyword(s):  
Rheumatoid Arthritis ◽  
Medicinal Plants ◽  
Systemic Disease ◽  
Modern Medicine ◽  
Whole Body ◽  
Internal Organs ◽  
Synthetic Drugs ◽  
Relieve Pain ◽  
Medicinal Treatment ◽  
Natural Drugs

The pharmacological mechanisms of the medicinal plants traditionally used for RA in Persian medicine are discussed in the current review. Further investigations are mandatory to focus on bioefficacy of these phytochemicals for finding novel natural drugs. Rheumatoid arthritis is chronic, progressive, disabling autoimmune disease characterized by systemic inflammation of joints, damaging cartilage and bone around the joints. It is a systemic disease which means that it can affect the whole body and internal organs such as lungs, heart and eyes. Although numbers of synthetic drugs are being used as standard treatment for rheumatoid arthritis but they have adverse effect that can compromise the therapeutic treatment. Unfortunately, there is still no effective known medicinal treatment that cures rheumatoid arthritis as the modern medicine can only treat the symptoms of this disease that means to relieve pain and inflammation of joints. It is possible to use the herbs and plants in various forms in order to relieve the pain and inflammation in the joints. There are so many medicinal plants that have shown anti rheumatoid arthritis properties. So the plants and plant product with significant advantages are used for the treatment of rheumatoid arthritis. The present review is focused on the medicinal plants having anti rheumatoid arthritis activity

Sign in / Sign up

Export Citation Format

Share Document