scholarly journals Evaluation Of Expression Patterns Of Cytokeratin And Mucin Peptide Core Antigen For Diagnostic Role In Upper Gastrointestinal Tract Pre Neoplastic And Neoplastic Lesions

2018 ◽  
Vol 5 (11) ◽  
pp. A952-962
Author(s):  
Mallika Dixit ◽  
Shruti Sharma ◽  
Zeeba Shamim Jairajpuri ◽  
Sujala Kapur ◽  
Usha Agrawal ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Expression Patterns ◽  
Upper Gastrointestinal Tract ◽  
Core Antigen ◽  
Neoplastic Lesions ◽  
Diagnostic Role ◽  
Upper Gastrointestinal ◽  
Peptide Core

scholarly journals Histopathological Study of Upper Gastrointestinal Tract Endoscopic Biopsies

2019 ◽  
Vol 6 (1) ◽  
pp. 42-46
Author(s):  
Mosammat Suchana Nazrin ◽  
Nur E Jannatul Ferdous ◽  
Madhusudan Saha ◽  
Fahmi Iqbal Rabbi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Gastrointestinal Tract ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Upper Gastrointestinal Tract ◽  
North East ◽  
Endoscopic Biopsies ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions ◽  
Upper Gastrointestinal

Background: Diseases of gastrointestinal tract are a major cause of morbidity and mortality. Objective: This study was carried out to determine the spectrum of histopathological lesions of upper gastrointestinal tract. Methodology: This retrospective study was conducted in the Department of Pathology at North East Medical College, Sylhet, Bangladesh during a 36 months period from January 2013 to December 2015. Endoscopies were performed using Olympus 150, forward viewing upper GI endoscope. The biopsy specimens received were fixed in 10.0% formalin and routinely processed in Haematoxyline & Eosin stain. Results: The present study included 135 endoscopic biopsies. The mean age with SD of the study population was 53.20±16.09 years. Among 53 cases of esophageal biopsies 8(15.08%) cases showed non-neoplastic lesions and 45(84.92%) cases were neoplastic of which 39(73.6%) cases and 6(11.32%) cases were squamous cell carcinoma and adenocarcinoma respectively. Among 6 cases of gastro esophageal junction biopsies 3(50%) cases showed non-neoplastic lesions and 3(50%) were neoplastic, of which 2(33.33%) were adenocarcinoma and 1(16.67%) were squamous cell carcinoma. Among 61 cases of stomach biopsies 34(55.74%) showed non-neoplastic lesions and 27(44.26%) were neoplastic, of which 1(1.64%) case was adenoma and 25(40.98%) were adenocarcinoma. Among 15 cases of duodenal biopsies 13(86.67%) cases showed non-neoplastic lesions and 2(13.33%) were neoplastic one of which was adenocarcinoma (6.67%). Among 135 cases endoscopist reported 82(60.74%) cases as neoplastic and 53(39.26%) as non-neoplastic, whereas histopathology revealed 77(57.03%) cases neoplastic and 58(42.97%) cases non-neoplastic. Conclusion: Common site of upper GIT endoscopic biopsy is stomach which are mostly neoplastic lesion; however, most common malignancy is squamous cell carcinoma of the oesophagus. Journal of Current and Advance Medical Research 2019;6(1):42-46

scholarly journals Prospective Study on Histopathological Spectrum of Upper Gastrointestinal Tract Lesions in a Teaching Hospital of Southern India

2020 ◽  
Author(s):  
Eslavath Aruna ◽  
V Kalyan Chakravarthy
Keyword(s):  
Gastrointestinal Tract ◽  
Histopathological Examination ◽  
Tissue Sample ◽  
Age Groups ◽  
Upper Gastrointestinal Tract ◽  
Female Ratio ◽  
Inflammatory Conditions ◽  
Endoscopic Biopsies ◽  
Neoplastic Lesions ◽  
Upper Gastrointestinal

Introduction: The Upper Gastrointestinal Tract (UGIT) disorders are quite common in routine clinical practice and have high degree of morbidity and mortality. They can be studied by collecting tissue sample by way of fiberoptic endoscope and by subjecting the tissue to histopathological examination. Aim: To study the spectrum of histopathological lesions of UGIT lesions by endoscopy. Materials and Methods: This was a prospective observational study done in the Department of Pathology at PSIMS, Chinna Avutapalli, Andhra Pradesh, India, over a period of one year from March 2019 to February 2020 on 160 endoscopic biopsies. All UGIT endoscopic biopsies received were examined histopathologically. The data was entered into excel sheets and percentages and ratios were calculated. Results: Lesions of UGIT were more common in the age groups of 31 to 50 years and the male to female ratio was 1.9:1. The patient age ranged from 20 years to 78 years. Stomach was the common site for UGIT endoscopic biopsies i.e., 80 (50%) followed by oesophagus 50 (31.2%) and then duodenum 30 (18.7%). At all three sites, non-neoplastic lesions predominated over neoplastic lesions. The gastric malignancies were more common in antral and pyloric regions. Conclusion: Males in the fourth and fifth decades are more prone for UGIT lesions with predominance of chronic non-specific inflammatory conditions as compared to neoplastic conditions. Malignancy within the stomach, more commonly affects the antrum and pylorus. Malignant lesions are very rare in duodenum.

scholarly journals Diagnostic ability of linked color imaging in ultraslim endoscopy to identify neoplastic lesions in the upper gastrointestinal tract

2022 ◽  
Vol 10 (01) ◽  
pp. E88-E95
Author(s):  
Ken Haruma ◽  
Mototsugu Kato ◽  
Kenro Kawada ◽  
Takahisa Murao ◽  
Shoko Ono ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Prospective Trial ◽  
Exploratory Analysis ◽  
Upper Gastrointestinal Tract ◽  
Color Imaging ◽  
Neoplastic Lesion ◽  
Multicenter Randomized Controlled Trial ◽  
Neoplastic Lesions ◽  
Linked Color Imaging ◽  
Upper Gastrointestinal

Abstract Background and study aims Linked color imaging (LCI) is a new image-enhancing technique that facilitates the differentiation of slight differences in mucosal color tone. We performed an exploratory analysis to evaluate the diagnostic capability of LCI in ultraslim endoscopy, using data from patients examined in the LCI-Further Improving Neoplasm Detection in upper gastrointestinal (LCI-FIND) trial, a large-scale, multicenter, randomized controlled trial that demonstrated the capability of LCI for detecting neoplastic lesions in the upper gastrointestinal tract. Patients and methods Data from the LCI-FIND prospective trial were used. In the LCI-FIND trial, 1502 patients with a history of gastrointestinal cancer were randomly assigned to two groups based on examination methods: white light imaging (WLI) followed by LCI (WLI group) and LCI followed by WLI (LCI group). The present exploratory analysis investigated the outcomes of patients who underwent ultraslim and standard endoscopies. Results Ultraslim endoscopes were used in 223 patients and standard endoscopes in 1279 patients. The primary endpoint of the LCI-FIND trial was the percentage of patients diagnosed with a neoplastic lesion using WLI or LCI. The corresponding percentage tended to be higher with LCI than with WLI among patients who underwent ultraslim endoscopy and among those who underwent standard endoscopy; the crude risk ratio was 2.21 [95 % confidence interval (CI): 1.06–4.67], and the adjusted odds ratio was 2.46 (95 % CI: 1.07–5.63). Conclusions Our exploratory analysis of data from the LCI-FIND trial showed that LCI is useful in identifying neoplastic lesions, when used in ultraslim endoscopy.

Intraluminal Pressures from the Upper Gastrointestinal Tract

1957 ◽  
Vol 32 (6) ◽  
pp. 1013-1024 ◽  
Author(s):  
E. Clinton Texter ◽  
Hubbard W. Smith ◽  
Hugo C. Moeller ◽  
Clifford J. Barborka
Keyword(s):  
Gastrointestinal Tract ◽  
Upper Gastrointestinal Tract ◽  
Upper Gastrointestinal
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