Detection of DNA Adducts in Human Breast Tissues

1997 ◽  
Author(s):  
Roger Giese
Keyword(s):  
Dna Adducts ◽  
Human Breast ◽  
Breast Tissues

scholarly journals Oncologic photodynamic diagnosis and therapy: confocal Raman/fluorescence imaging of metal phthalocyanines in human breast cancer tissue in vitro

The Analyst ◽  
2014 ◽  
Vol 139 (21) ◽  
pp. 5547-5559 ◽  
Author(s):  
Halina Abramczyk ◽  
Beata Brozek-Pluska ◽  
Jakub Surmacki ◽  
Jacek Musial ◽  
Radzislaw Kordek
Keyword(s):  
Breast Cancer Tissue ◽  
Photodynamic Diagnosis ◽  
Cancer Tissue ◽  
Human Breast ◽  
Human Breast Cancer Tissue ◽  
Metal Phthalocyanines ◽  
Confocal Fluorescence ◽  
Confocal Raman ◽  
Breast Tissues

Raman microspectroscopy and confocal Raman imaging combined with confocal fluorescence were used to study the distribution and aggregation of aluminum tetrasulfonated phthalocyanine (AlPcS4) in breast tissues.

Spectral Characterization of Catechol Estrogen Quinone (CEQ)-Derived DNA Adducts and Their Identification in Human Breast Tissue Extract

2003 ◽  
Vol 16 (9) ◽  
pp. 1107-1117 ◽  
Author(s):  
Y. Markushin ◽  
W. Zhong ◽  
E. L. Cavalieri ◽  
E. G. Rogan ◽  
G. J. Small ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Breast Tissue ◽  
Spectral Characterization ◽  
Tissue Extract ◽  
Human Breast ◽  
Human Breast Tissue ◽  
Catechol Estrogen

scholarly journals AKT1 is differentially expressed in primary tumors and brain metastases in humans with breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Central Nervous System Metastasis ◽  
Human Breast ◽  
Primary Tumors ◽  
Breast Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We report here the differential expression of the protein kinase AKT1 in the primary tumors and brain metastases of humans with breast cancer. AKT1 mRNA was present at significantly increased quantities in brain metastatic tissues as compared to primary tumors of the breast. These data combined suggest that up-regulation of AKT1 is a conserved event, both during transformation of breast tissues and progression to central nervous system metastasis and further point to potential importance of AKT1 modulation during progression of human breast cancer.

Fluorescence study of normal, benign, and malignant human breast tissues

2000 ◽  
Author(s):  
Asima Pradhan ◽  
R. N. Panda ◽  
Maya S. Nair ◽  
B. V. Laxmi ◽  
Asha Agarwal ◽  
...  
Keyword(s):  
Human Breast ◽  
Fluorescence Study ◽  
Breast Tissues

Differences in Polyamine Metabolism between Carcinomatous and Uninvolved Human Breast Tissues

1986 ◽  
Vol 1 (2) ◽  
pp. 77-80 ◽  
Author(s):  
Marta Romano ◽  
Maria Assunta Santacroce ◽  
Patrizia Bonelli ◽  
Luigi Cecco ◽  
Maria Cerra
Keyword(s):  
Cell Growth ◽  
Breast Tissue ◽  
Lower Activity ◽  
Polyamine Metabolism ◽  
Biosynthetic Enzymes ◽  
Human Breast ◽  
Human Breast Tissue ◽  
Breast Tissues

The polyamine biosynthetic enzymes ODC and SAMDC show higher activity in carcinomatous human breast tissue than in uninvolved tissue of the same breast; the interconversion enzyme PAO shows significantly lower activity in carcinomatous than uninvolved tissue. The polyamine metabolism in carcinomatous human breast tissue thus appears to differ from that in uninvolved tissue. Intracellular polyamine concentrations, particularly spermine, are high in carcinomatous tissue. This increase and that of the biosynthetic enzymes suggest that a higher polyamine concentration is needed for carcinomatous cell growth. If this is the case, the lower PAO activity in carcinomatous tissue may be explained as a mechanism that conserves the high intracellular polyamine concentration.

Distribution of oncofetal fibronectin isoforms in normal, hyperplastic and neoplastic human breast tissues

1994 ◽  
Vol 59 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Janusz Kaczmarek ◽  
Patrizia Castellani ◽  
Guido Nicolo ◽  
Bruno Spina ◽  
Giorgio Allemanni ◽  
...  
Keyword(s):  
Human Breast ◽  
Oncofetal Fibronectin ◽  
Breast Tissues ◽  
Fibronectin Isoforms
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