Early Detection of Ovarian Cancer by Contrast-Enhanced Ultrasound-Targeted Imaging

2013 ◽  
Author(s):  
Animesh Barua
Keyword(s):  
Ovarian Cancer ◽  
Early Detection ◽  
Targeted Imaging ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

Enhancement of Ovarian Tumor Detection by DR6-Targeted Ultrasound Imaging Agents in Laying Hen Model of Spontaneous Ovarian Cancer

2016 ◽  
Vol 26 (8) ◽  
pp. 1375-1385 ◽  
Author(s):  
Animesh Barua ◽  
Seby L. Edassery ◽  
Sa’Rah McNeal ◽  
Janice M. Bahr ◽  
Pincas Bitterman ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Early Detection ◽  
Ultrasound Imaging ◽  
Signal Intensity ◽  
Laying Hen ◽  
Imaging Agents ◽  
Targeted Imaging ◽  
Malignant Cells ◽  
Targeted Ultrasound ◽  
Signal Intensities

ObjectiveThe lack of an effective early detection test leads to high case to death ratio of women with ovarian cancer (OVCA). To improve early detection, tumor-associated imaging targets need to be established and imaging agents to image these targets need to be developed. Targeted imaging agents offer potential for improvement of signal intensities from their targets. Expression of death receptor 6 (DR6) by ovarian malignant cells and tumor-associated microvessels increases during OVCA development and represents a novel target for ultrasound imaging. The goal of this study was to examine the feasibility of newly developed DR6-targeted ultrasound imaging agents in enhancing early detection of ovarian tumors in laying hen model of spontaneous OVCA.Materials and MethodsThe study was conducted in an exploratory cross-sectional design using 4-year-old laying hens (n = 130). DR6-targeted imaging agents were developed by conjugating microbubbles with rabbit anti-chicken DR6 antibodies. Changes in signal intensity of ultrasound imaging were determined before and after injection of targeted imaging agents in hens with or without spontaneous OVCA. Following targeted imaging, normal or tumor ovaries were processed for histopathological and immunohistochemical studies.ResultsDR6-targeted imaging agents bound with their targets expressed by malignant cells and tumor-associated microvessels in the ovary. Compared with pretargeted imaging, targeted imaging is enhanced by approximately 40% ultrasound echo signal intensity (P< 0.001) from early- and late-stage OVCA. Differences in signal enhancement were not observed among different histological subtypes of OVCA at early or late stages. Higher imaging signal intensities were associated with enhancement in DR6 expression by ovarian malignant cells and increase in the frequency of DR6-expressing microvessels during OVCA development.ConclusionsThe results of this study suggest that DR6-targeted imaging agents enhance the visualization of ovarian tumors and tumor-associated microvessels in hens with early-stage OVCA and will form a foundation for clinical studies.

Contrast-Enhanced Ultrasound and Near-Infrared Spectroscopy of the Neonatal Bowel: Novel, Bedside, Noninvasive, and Radiation-Free Imaging for Early Detection of Necrotizing Enterocolitis

2018 ◽  
Vol 35 (14) ◽  
pp. 1358-1365 ◽  
Author(s):  
Suzanne Al-Hamad ◽  
David Hackam ◽  
Seth Goldstein ◽  
Thierry Huisman ◽  
Kassa Darge ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Early Detection ◽  
Necrotizing Enterocolitis ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Morbidity And Mortality ◽  
Contrast Enhanced Ultrasound ◽  
Noninvasive Technique ◽  
Initial Development ◽  
Contrast Enhanced

AbstractDespite extensive research and improvements in the field of neonatal care, the morbidity and mortality associated with necrotizing enterocolitis (NEC) have remained unchanged over the past three decades. Early detection of ischemia and necrotic bowel is vital in improving morbidity and mortality associated with NEC; however, strategies for predicting and preventing NEC are lacking. Contrast-enhanced ultrasound (CEUS) and near-infrared spectroscopy (NIRS) are novel techniques in pediatrics that have been proven as safe modalities. CEUS has benefits over conventional ultrasound (US) by its improved real-time evaluation of the micro- and macrovascularities of normally and abnormally perfused tissue. US has been implemented as a useful adjunct to X-ray for earlier evaluation of NEC. NIRS is another noninvasive technique that has shown promise in improving early detection of NEC. The purpose of this article is to review the current understanding of changes in bowel perfusion in NEC, discuss the accuracy of abdominal US in detecting NEC, and explain how the use of CEUS and NIRS will enhance the precise and early detection of altered/pathological bowel wall perfusion in the initial development and course of NEC.

Radiofrequency ablation of renal tumours: diagnostic accuracy of contrast-enhanced ultrasound for early detection of residual tumour

2010 ◽  
Vol 20 (8) ◽  
pp. 1812-1821 ◽  
Author(s):  
Christine Hoeffel ◽  
Maud Pousset ◽  
Marc-Olivier Timsit ◽  
Caroline Elie ◽  
Arnaud Méjean ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Early Detection ◽  
Diagnostic Accuracy ◽  
Residual Tumour ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Renal Tumours

scholarly journals Contrast-Enhanced Ultrasound Imaging of Prostate Gland in Neutered Dogs

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 559
Author(s):  
Stefano Spada ◽  
Gary C. W. England ◽  
Massimo Vignoli ◽  
Augusto Carluccio ◽  
Marco Russo
Keyword(s):  
Early Detection ◽  
Contrast Agent ◽  
Prostate Volume ◽  
Prostate Gland ◽  
Contrast Enhanced Ultrasound ◽  
Time To Peak ◽  
Peak Intensity ◽  
Linear Transducer ◽  
Contrast Enhanced ◽  
Rim Enhancement

Prostatic neoplasia (PN) occurs in 5–7% of dogs with prostatic disease, with castrated dogs having the same or higher prevalence when compared to intact dogs. Considering the promising results achieved by performing contrast-enhanced ultrasound (CEUS) in intact dogs to detect PN, the present study aimed to acquire data on the prostatic perfusion pattern in neutered dogs. CEUS was performed in 64 neutered dogs, using a 5–7.5 MHz linear transducer with coded harmonic capability, dedicated analytical software, and a second-generation contrast agent, SonoVue. After B-mode evaluation was performed to assess mean prostate volume, the CEUS examination was undertaken. The flow of contrast agent was visible 10 s after injection. The subcapsular vessels were highlighted and produced rapid peripheral rim enhancement. Subsequently, the contrast agent reached the prostatic urethra via the parenchymal arterioles and gradually reached the entire prostate. Perfusion peak intensity (PPI) and time to peak (TTP) values were respectively 45.3% and 34.1 s. The measured parameters were compared with those obtained in previous studies on intact dogs with normal and with pathological patterns. In this study, CEUS showed features that may be promising for its use as a diagnostic tool for early detection of PN in neutered dogs.

scholarly journals The Correlation between Targeted Contrast-Enhanced Ultrasound Imaging and Tumor Neovascularization of Ovarian Cancer Xenografts in Nude Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Rong Hu ◽  
Qianqian Zeng ◽  
Xiaoling Su ◽  
Wenxia Feng ◽  
Hong Xiang
Keyword(s):  
Ovarian Cancer ◽  
Ultrasound Imaging ◽  
Nude Mice ◽  
Growth Time ◽  
Contrast Enhanced Ultrasound ◽  
Time To Peak ◽  
Imaging Parameters ◽  
Contrast Enhanced ◽  
Tumor Neovascularization ◽  
Contrast Ultrasound

In order to explore the correlation between targeted contrast-enhanced ultrasound imaging and tumor neovascularization of ovarian cancer xenografts in nude mice, a total of 49 nude mice were selected and randomly divided into 1-week group, 2-week group, 3-week group, 4-week group, 5-week group, 6-week group, and 7-week group according to their ovarian cancer xenografts’ growth time, with 7 ovarian cancer xenografts in each group. After preparing antibody-carrying targeted contrast agent, each group of xenografts performed normal and targeted contrast ultrasound examinations to obtain peak intensity, time to peak, and other imaging parameters; then, those ovarian cancer xenografts were sacrificed for pathological analysis: the neovascular density and antibody expression of the cancer xenografts at different stages were observed and counted, and the correlation between targeted contrast-enhanced ultrasound parameters and tumor neovascular densities of the ovarian cancer xenografts was analyzed. The results show that the peak intensities of targeted contrast ultrasound imaging are greater than that of ordinary ultrasound imaging in the 2-, 3-, 4-, and 5-week groups with statistically significant differences ( P < 0.05 ); the time to peak of targeted contrast ultrasound imaging is shorter than that of ordinary ultrasound imaging in the 2-, 3-, 4-, and 5-week groups with statistically significant differences ( P < 0.05 ); there is a positive correlation between the peak intensities of targeted contrast ultrasound imaging and tumor neovascular densities of the ovarian cancer xenografts in the 2-, 3-, and 4-week group (r2 = 0.645, r3 = 0.668, and r4 = 0.693, P < 0.05 ); there is a negative correlation between the time to peak of targeted contrast ultrasound imaging and tumor neovascular densities of the ovarian cancer xenografts in the 2-, 3-, and 4-week groups (r2 = −0.669, r3 = −0.692, and r4 = −0.704, P < 0.05 ). Therefore, the targeted contrast-enhanced ultrasound imaging parameters have a certain correlation with tumor neovascular density of ovarian cancer xenografts in nude mice and this correlation is more significant in the early stage of ovarian cancer; hence, targeted contrast-enhanced ultrasound imaging may provide a new method, new idea, and new basis for the diagnosis of early ovarian cancer.

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