scholarly journals EP30.05: Contrast‐enhanced ultrasound imaging with MMP‐2 targeted microbubbles enhances detection of early‐stage vasculogenic mimicry in ovarian cancer xenograft

2019 ◽  
Vol 54 (S1) ◽  
pp. 421-421
Author(s):  
H. Xiang
Keyword(s):  
Ovarian Cancer ◽  
Ultrasound Imaging ◽  
Early Stage ◽  
Vasculogenic Mimicry ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Targeted Microbubbles

scholarly journals The Correlation between Targeted Contrast-Enhanced Ultrasound Imaging and Tumor Neovascularization of Ovarian Cancer Xenografts in Nude Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Rong Hu ◽  
Qianqian Zeng ◽  
Xiaoling Su ◽  
Wenxia Feng ◽  
Hong Xiang
Keyword(s):  
Ovarian Cancer ◽  
Ultrasound Imaging ◽  
Nude Mice ◽  
Growth Time ◽  
Contrast Enhanced Ultrasound ◽  
Time To Peak ◽  
Imaging Parameters ◽  
Contrast Enhanced ◽  
Tumor Neovascularization ◽  
Contrast Ultrasound

In order to explore the correlation between targeted contrast-enhanced ultrasound imaging and tumor neovascularization of ovarian cancer xenografts in nude mice, a total of 49 nude mice were selected and randomly divided into 1-week group, 2-week group, 3-week group, 4-week group, 5-week group, 6-week group, and 7-week group according to their ovarian cancer xenografts’ growth time, with 7 ovarian cancer xenografts in each group. After preparing antibody-carrying targeted contrast agent, each group of xenografts performed normal and targeted contrast ultrasound examinations to obtain peak intensity, time to peak, and other imaging parameters; then, those ovarian cancer xenografts were sacrificed for pathological analysis: the neovascular density and antibody expression of the cancer xenografts at different stages were observed and counted, and the correlation between targeted contrast-enhanced ultrasound parameters and tumor neovascular densities of the ovarian cancer xenografts was analyzed. The results show that the peak intensities of targeted contrast ultrasound imaging are greater than that of ordinary ultrasound imaging in the 2-, 3-, 4-, and 5-week groups with statistically significant differences ( P < 0.05 ); the time to peak of targeted contrast ultrasound imaging is shorter than that of ordinary ultrasound imaging in the 2-, 3-, 4-, and 5-week groups with statistically significant differences ( P < 0.05 ); there is a positive correlation between the peak intensities of targeted contrast ultrasound imaging and tumor neovascular densities of the ovarian cancer xenografts in the 2-, 3-, and 4-week group (r2 = 0.645, r3 = 0.668, and r4 = 0.693, P < 0.05 ); there is a negative correlation between the time to peak of targeted contrast ultrasound imaging and tumor neovascular densities of the ovarian cancer xenografts in the 2-, 3-, and 4-week groups (r2 = −0.669, r3 = −0.692, and r4 = −0.704, P < 0.05 ). Therefore, the targeted contrast-enhanced ultrasound imaging parameters have a certain correlation with tumor neovascular density of ovarian cancer xenografts in nude mice and this correlation is more significant in the early stage of ovarian cancer; hence, targeted contrast-enhanced ultrasound imaging may provide a new method, new idea, and new basis for the diagnosis of early ovarian cancer.

Contrast-Enhanced Ultrasound Imaging for Aortic Stent-Graft Surveillance

2003 ◽  
Vol 10 (2) ◽  
pp. 208-217 ◽  
Author(s):  
Maria Fabrizia Giannoni ◽  
Giovanni Palombo ◽  
Enrico Sbarigia ◽  
Francesco Speziale ◽  
Alvaro Zaccaria ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Stent Graft ◽  
Contrast Enhanced Ultrasound ◽  
Aortic Stent Graft ◽  
Contrast Enhanced

scholarly journals Contrast-Enhanced Ultrasound (CEUS) in Non-Traumatic Abdominal Emergencies

2020 ◽  
Vol 06 (03) ◽  
pp. E76-E86
Author(s):  
Diletta Cozzi ◽  
Simone Agostini ◽  
Elena Bertelli ◽  
Michele Galluzzo ◽  
Emanuela Papa ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Ultrasound Imaging ◽  
Acute Inflammation ◽  
Emergency Setting ◽  
Contrast Enhanced Ultrasound ◽  
First Line ◽  
Additional Information ◽  
Contrast Enhanced ◽  
Conventional Ultrasound ◽  
Abdominal Emergencies

AbstractConventional ultrasound imaging (US) is the first-line investigation in acute non-traumatic abdominal emergencies, but sometimes it needs further examinations, such as computed tomography (CT), to reach a certain diagnosis. Contrast-enhanced ultrasound (CEUS), through injection of contrast medium, may provide the radiologist with additional information that could not be investigated with baseline US. It could help reach a diagnosis and rapidly determine the proper therapy in an emergency setting. The purpose of this review is to explain and illustrate the various possibilities and limitations of CEUS in acute non-traumatic abdominal diseases, in particular acute inflammation, parenchymal infarcts, and hemorrhages.

scholarly journals The biological response of rodent kidneys to low frequency, full volume diagnostic contrast-enhanced ultrasound imaging: Pilot data

Data in Brief ◽  
2019 ◽  
Vol 25 ◽  
pp. 104170
Author(s):  
A. Gloria Nyankima ◽  
Sandeep Kasoji ◽  
Rachel Cianciolo ◽  
Paul A. Dayton ◽  
Emily H. Chang
Keyword(s):  
Ultrasound Imaging ◽  
Low Frequency ◽  
Biological Response ◽  
Contrast Enhanced Ultrasound ◽  
Pilot Data ◽  
Contrast Enhanced ◽  
Full Volume
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