Sonophoresis for Rapid Assessment of Interstitial Fluid and Drug Delivery

2007 ◽  
Author(s):  
Samir Mitragotri
Keyword(s):  
Drug Delivery ◽  
Interstitial Fluid ◽  
Rapid Assessment

Effect of Tumor Volume on Drug Delivery in Heterogeneous Vasculature of Human Brain Tumors

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Ajay Bhandari ◽  
Ankit Bansal ◽  
Rishav Jain ◽  
Anup Singh ◽  
Niraj Sinha
Keyword(s):  
Drug Delivery ◽  
Brain Tumors ◽  
Human Brain ◽  
Contrast Agent ◽  
Large Volume ◽  
Interstitial Fluid ◽  
Tumor Volume ◽  
Drug Distribution ◽  
Dce Mri ◽  
Concentration Of Contrast Agent

Drug distribution in tumors is strongly dependent on tumor biological properties such as tumor volume, vasculature, and porosity. An understanding of the drug distribution pattern in tumors can help in enhancing the effectiveness of anticancer treatment. A numerical model is employed to study the distribution of contrast agent in the heterogeneous vasculature of human brain tumors of different volumes. Dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) has been done for a number of patients with different tumor volumes. Leaky tracer kinetic model (LTKM) is employed to obtain perfusion parameters from the DCE-MRI data. These parameters are used as input in the computational fluid dynamics (CFD) model to predict interstitial fluid pressure (IFP), interstitial fluid velocity (IFV), and distribution of the contrast agent in different tumors. Numerical results demonstrate that the IFP is independent of tumor volume. On the other hand, the IFV increases as the tumor volume increases. Further, the concentration of contrast agent also increases with the tumor volume. The results obtained in this work are in line with the experimental DCE-MRI data. It is observed that large volume tumors tend to retain a higher concentration of contrast agent for a longer duration of time because of large extravasation flux and slow washout as compared to smaller tumors. These results may be qualitatively extrapolated to chemotherapeutic drug delivery, implying faster healing in large volume tumors. This study helps in understanding the effect of tumor volume on the treatment outcome for a wide range of human tumors.

scholarly journals Rapid assessment of ocular drug delivery in a novel ex vivo corneal model

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ghazala Begum ◽  
Thomas Leigh ◽  
Ella Courtie ◽  
Richard Moakes ◽  
Gibran Butt ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ex Vivo ◽  
Rapid Assessment ◽  
Ocular Drug Delivery

Numerical simulation of the tumor interstitial fluid transport: Consideration of drug delivery mechanism

2015 ◽  
Vol 101 ◽  
pp. 62-71 ◽  
Author(s):  
Mohammad Charjouei Moghadam ◽  
Amin Deyranlou ◽  
Alireza Sharifi ◽  
Hamid Niazmand
Keyword(s):  
Numerical Simulation ◽  
Drug Delivery ◽  
Interstitial Fluid ◽  
Fluid Transport ◽  
Tumor Interstitial Fluid ◽  
Delivery Mechanism

scholarly journals Targeting the invincible barrier for drug delivery in solid cancers: interstitial fluid pressure

Oncotarget ◽  
2018 ◽  
Vol 9 (87) ◽  
pp. 35723-35725 ◽  
Author(s):  
Steven K. Libutti ◽  
Lawrence Tamarkin ◽  
Naris Nilubol
Keyword(s):  
Drug Delivery ◽  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure

scholarly journals Microvasculature-on-a-Chip: Bridging the interstitial blood-lymph interface via mechanobiological stimuli

2021 ◽  
Author(s):  
Barbara Bachmann ◽  
Sarah Spitz ◽  
Christian Jordan ◽  
Patrick Schuller ◽  
Heinz D Wanzenboeck ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluid Flow ◽  
Interstitial Fluid ◽  
Lymphatic System ◽  
Immune Cell ◽  
Scientific Progress ◽  
Morphological Characteristics ◽  
Interstitial Fluid Flow

After decades of simply being referred to as the body's sewage system, the lymphatic system has recently been recognized as a key player in numerous physiological and pathological processes. As an essential site of immune cell interactions, the lymphatic system is a potential target for next-generation drug delivery approaches in treatments for cancer, infections, and inflammatory diseases. However, the lack of cell-based assays capable of recapitulating the required biological complexity combined with unreliable in vivo animal models currently hamper scientific progress in lymph-targeted drug delivery. To gain more in-depth insight into the blood-lymph interface, we established an advanced chip-based microvascular model to study mechanical stimulation's importance on lymphatic sprout formation. Our microvascular model's key feature is the co-cultivation of spatially separated 3D blood and lymphatic vessels under controlled, unidirectional interstitial fluid flow while allowing signaling molecule exchange similar to the in vivo situation. We demonstrate that our microphysiological model recreates biomimetic interstitial fluid flow, mimicking the route of fluid in vivo, where shear stress within blood vessels pushes fluid into the interstitial space, which is subsequently transported to the nearby lymphatic capillaries. Results of our cell culture optimization study clearly show an increased vessel sprouting number, length, and morphological characteristics under dynamic cultivation conditions and physiological relevant mechanobiological stimulation. For the first time, a microvascular on-chip system incorporating microcapillaries of both blood and lymphatic origin in vitro recapitulates the interstitial blood-lymph interface.

scholarly journals Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors

2021 ◽  
Author(s):  
Mostafa Sefidgar ◽  
M Soltani ◽  
Kaamran Raahemifar ◽  
Hossein Bazmara ◽  
Seyed Mojtaba Mousavi Nayinian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluid Flow ◽  
Solute Transport ◽  
Solid Tumor ◽  
Drug Concentration ◽  
Interstitial Fluid ◽  
Initial Conditions ◽  
Surrounding Tissue ◽  
Governing Equations ◽  
Tumor Shape

Background The computational methods provide condition for investigation related to the process of drug delivery, such as convection and diffusion of drug in extracellular matrices, drug extravasation from microvessels or to lymphatic vessels. The information of this process clarifies the mechanisms of drug delivery from the injection site to absorption by a solid tumor. In this study, an advanced numerical method is used to solve fluid flow and solute transport equations simultaneously to investigate the effect of tumor shape and size on drug delivery to solid tumor. Methods The advanced mathematical model used in our previous work is further developed by adding solute transport equation to the governing equations. After applying appropriate boundary and initial conditions on tumor and surrounding tissue geometry, the element-based finite volume method is used for solving governing equations of drug delivery in solid tumor. Also, the effects of size and shape of tumor and some of tissue transport parameters such as effective pressure and hydraulic conductivity on interstitial fluid flow and drug delivery are investigated. Results Sensitivity analysis shows that drug delivery in prolate shape is significantly better than other tumor shapes. Considering size effect, increasing tumor size decreases drug concentration in interstitial fluid. This study shows that dependency of drug concentration in interstitial fluid to osmotic and intravascular pressure is negligible. Conclusions This study shows that among diffusion and convection mechanisms of drug transport, diffusion is dominant in most different tumor shapes and sizes. In tumors in which the convection has considerable effect, the drug concentration is larger than that of other tumors at the same time post injection.

scholarly journals Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors

2021 ◽  
Author(s):  
Mostafa Sefidgar ◽  
M Soltani ◽  
Kaamran Raahemifar ◽  
Hossein Bazmara ◽  
Seyed Mojtaba Mousavi Nayinian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluid Flow ◽  
Solute Transport ◽  
Solid Tumor ◽  
Drug Concentration ◽  
Interstitial Fluid ◽  
Initial Conditions ◽  
Surrounding Tissue ◽  
Governing Equations ◽  
Tumor Shape

Background The computational methods provide condition for investigation related to the process of drug delivery, such as convection and diffusion of drug in extracellular matrices, drug extravasation from microvessels or to lymphatic vessels. The information of this process clarifies the mechanisms of drug delivery from the injection site to absorption by a solid tumor. In this study, an advanced numerical method is used to solve fluid flow and solute transport equations simultaneously to investigate the effect of tumor shape and size on drug delivery to solid tumor. Methods The advanced mathematical model used in our previous work is further developed by adding solute transport equation to the governing equations. After applying appropriate boundary and initial conditions on tumor and surrounding tissue geometry, the element-based finite volume method is used for solving governing equations of drug delivery in solid tumor. Also, the effects of size and shape of tumor and some of tissue transport parameters such as effective pressure and hydraulic conductivity on interstitial fluid flow and drug delivery are investigated. Results Sensitivity analysis shows that drug delivery in prolate shape is significantly better than other tumor shapes. Considering size effect, increasing tumor size decreases drug concentration in interstitial fluid. This study shows that dependency of drug concentration in interstitial fluid to osmotic and intravascular pressure is negligible. Conclusions This study shows that among diffusion and convection mechanisms of drug transport, diffusion is dominant in most different tumor shapes and sizes. In tumors in which the convection has considerable effect, the drug concentration is larger than that of other tumors at the same time post injection.

Transient interstitial fluid flow in brain tumors: Effect on drug delivery

2005 ◽  
Vol 60 (17) ◽  
pp. 4803-4821 ◽  
Author(s):  
Chee Seng Teo ◽  
Wilson Hor Keong Tan ◽  
Timothy Lee ◽  
Chi-Hwa Wang
Keyword(s):  
Drug Delivery ◽  
Fluid Flow ◽  
Brain Tumors ◽  
Interstitial Fluid ◽  
Interstitial Fluid Flow

Fluid Flow Behaviour in Microneedle Arrays

2005 ◽  
Author(s):  
A. N. San ◽  
R. Ben Mrad ◽  
P. Sullivan
Keyword(s):  
Drug Delivery ◽  
Fluid Flow ◽  
Cross Sections ◽  
Transdermal Drug Delivery ◽  
Interstitial Fluid ◽  
Flow Behaviour ◽  
Electrokinetic Effect ◽  
Microneedle Arrays ◽  
Minor Losses ◽  
Array Geometry

This paper examines the geometries of basic straight microneedle arrays, slanted channel arrays with varying angles, and arrays with diverging and converging interior cross sections for the purpose of interstitial fluid extraction and transdermal drug delivery. Flow behaviour is analyzed under biometric pressure driven conditions including frictional losses, minor losses due to the array geometry, and losses due to electrokinetic effect in microchannels. This paper also presents design and fabrication details of preliminary work that will lead to a design for microneedle arrays.

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