scholarly journals Targeting the invincible barrier for drug delivery in solid cancers: interstitial fluid pressure

Oncotarget ◽  
2018 ◽  
Vol 9 (87) ◽  
pp. 35723-35725 ◽  
Author(s):  
Steven K. Libutti ◽  
Lawrence Tamarkin ◽  
Naris Nilubol
Keyword(s):  
Drug Delivery ◽  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure

Control of interstitial fluid pressure: Role of [beta ]-integrins

2001 ◽  
Vol 21 (3) ◽  
pp. 222-230 ◽  
Author(s):  
Rolf K. Reed ◽  
Ansgar Berg ◽  
Eli-Anne B. Gjerde ◽  
Kristofer Rubin
Keyword(s):  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure

Dynamics of Interstitial Fluid Pressure in Extracellular Matrix Hydrogels in Microfluidic Devices

2015 ◽  
Vol 137 (9) ◽  
Author(s):  
Joe Tien ◽  
Le Li ◽  
Ozgur Ozsun ◽  
Kamil L. Ekinci
Keyword(s):  
Extracellular Matrix ◽  
Pressure Distribution ◽  
Interstitial Fluid ◽  
Scaling Laws ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure ◽  
External Loading ◽  
Interstitial Pressure ◽  
Time Resolved ◽  
Long Time

In order to understand how interstitial fluid pressure and flow affect cell behavior, many studies use microfluidic approaches to apply externally controlled pressures to the boundary of a cell-containing gel. It is generally assumed that the resulting interstitial pressure distribution quickly reaches a steady-state, but this assumption has not been rigorously tested. Here, we demonstrate experimentally and computationally that the interstitial fluid pressure within an extracellular matrix gel in a microfluidic device can, in some cases, react with a long time delay to external loading. Remarkably, the source of this delay is the slight (∼100 nm in the cases examined here) distension of the walls of the device under pressure. Finite-element models show that the dynamics of interstitial pressure can be described as an instantaneous jump, followed by axial and transverse diffusion, until the steady pressure distribution is reached. The dynamics follow scaling laws that enable estimation of a gel's poroelastic constants from time-resolved measurements of interstitial fluid pressure.

Simultaneous Measurement of Interstitial Fluid Pressure and Load in Rat Skin After Strain Application In Vitro

2003 ◽  
Vol 31 (10) ◽  
pp. 1246-1254 ◽  
Author(s):  
David M. Wright ◽  
Helge Wiig ◽  
C. Peter Winlove ◽  
Joel L. Bert ◽  
Rolf K. Reed
Keyword(s):  
Simultaneous Measurement ◽  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure ◽  
Rat Skin

scholarly journals Combined Anti-Angiogenic Therapy Targeting PDGF and VEGF Receptors Lowers the Interstitial Fluid Pressure in a Murine Experimental Carcinoma

PLoS ONE ◽  
2009 ◽  
Vol 4 (12) ◽  
pp. e8149 ◽  
Author(s):  
Agnieszka Kłosowska-Wardęga ◽  
Yoko Hasumi ◽  
Mikhail Burmakin ◽  
Aive Åhgren ◽  
Linda Stuhr ◽  
...  
Keyword(s):  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure ◽  
Vegf Receptors ◽  
Angiogenic Therapy ◽  
Experimental Carcinoma

scholarly journals A 3D CFD model of the interstitial fluid pressure and drug distribution in heterogeneous tumor nodules during intraperitoneal chemotherapy

Drug Delivery ◽  
2019 ◽  
Vol 26 (1) ◽  
pp. 404-415 ◽  
Author(s):  
Margo Steuperaert ◽  
Charlotte Debbaut ◽  
Charlotte Carlier ◽  
Olivier De Wever ◽  
Benedicte Descamps ◽  
...  
Keyword(s):  
Intraperitoneal Chemotherapy ◽  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Drug Distribution ◽  
Interstitial Fluid Pressure ◽  
Cfd Model ◽  
Heterogeneous Tumor
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