Characterization of the Pathological and Biochemical Markers that Correlate to the Clinical Features of Autism: The Neuropathological Markers of Abnormal Brain Development and Aging in Autism

2010 ◽  
Author(s):  
Thomas Wisniewski
Keyword(s):  
Brain Development ◽  
Clinical Features ◽  
Biochemical Markers ◽  
Development And Aging ◽  
Abnormal Brain

scholarly journals Characterization of cortical neurons that transiently express TH during rat brain development

2006 ◽  
Vol 295 (1) ◽  
pp. 405
Author(s):  
Steve Asmus ◽  
Mark Ball ◽  
Angela Bohnen ◽  
Kevin Phelps ◽  
Cindy Hartley ◽  
...  
Keyword(s):  
Brain Development ◽  
Rat Brain ◽  
Cortical Neurons

Imaging Normal and Abnormal Brain Development: New Perspectives for Child Psychiatry

2001 ◽  
Vol 35 (3) ◽  
pp. 272-281 ◽  
Author(s):  
Judith L. Rapoport ◽  
Xavier F. Castellanos ◽  
Nitin Gogate ◽  
Kristin Janson ◽  
Shawn Kohler ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Brain Development ◽  
Attention Deficit ◽  
Grey Matter ◽  
Brain Volume ◽  
Brain Magnetic Resonance Imaging ◽  
Childhood And Adolescence ◽  
Hyperactivity Disorder ◽  
Developmental Neuroscience ◽  
Abnormal Brain

Objective: The availability of non-invasive brain imaging permits the study of normal and abnormal brain development in childhood and adolescence. This paper summarizes current knowledge of brain abnormalities of two conditions, attention deficit hyperactivity disorder (ADHD) and childhood onset schizophrenia (COS), and illustrates how such findings are bringing clinical and preclinical perspectives closer together. Method: A selected review is presented of the pattern and temporal characteristics of anatomic brain magnetic resonance imaging (MRI) studies in ADHD and COS. These results are discussed in terms of candidate mechanisms suggested by studies in developmental neuroscience. Results: There are consistent, diagnostically specific patterns of brain abnormality for ADHD and COS. Attention deficit hyperactivity disorder is characterized by a slightly smaller (4%) total brain volume (both white and grey matter), less-consistent abnormalities of the basal ganglia and a striking (15%) decrease in posterior inferior cerebellar vermal volume. These changes do not progress with age. In contrast, patients with COS have smaller brain volume due to a 10% decrease in cortical grey volume. Moreover, in COS there is a progressive loss of regional grey volume particularly in frontal and temporal regions during adolescence. Conclusions: In ADHD, the developmental pattern suggests an early non-progressive ‘lesion’ involving neurotrophic factors controlling overall brain growth and selected dopamine circuits. In contrast, in COS, which shows progressive grey matter loss, various candidate processes influencing later synaptic and dendritic pruning are suggested by human post-mortem and developmental animal studies.

scholarly journals TRENDS OF CONTEMPORARY LEPTOSPIROSIS (REVIEW OF LITERATURE)

2018 ◽  
Vol 23 (2) ◽  
pp. 93-100
Author(s):  
Vladimir N. Gorodin ◽  
D. L. Moysova ◽  
V. A. Bakhtina ◽  
S. V. Zotov
Keyword(s):  
Organ Dysfunction ◽  
Clinical Features ◽  
Review Of Literature ◽  
Review Of The Literature ◽  
Disease Complex ◽  
Modern Information ◽  
Clinically Significant

A review of the literature is devoted to one of the most common and clinically significant zoonoses - leptospirosis. The article summarizes modern information on prevalence, epidemiology, etiopathogenesis and clinical features, diagnosis of leptospirosis infection over the last 10 years. The particular attention is paid to the characterization of severe forms of the disease, complex approaches to the treatment of the disease, correction of organ dysfunction and hemostasis disorders; review.

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