Metabolic Mapping of Breast Cancer with Multiphoton Spectral and Lifetime Imaging

2008 ◽  
Author(s):  
Long Yan
Keyword(s):  
Breast Cancer ◽  
Metabolic Mapping ◽  
Lifetime Imaging

scholarly journals Automated detection of breast cancer in resected specimens with fluorescence lifetime imaging

2017 ◽  
Vol 63 (1) ◽  
pp. 015003 ◽  
Author(s):  
Jennifer E Phipps ◽  
Dimitris Gorpas ◽  
Jakob Unger ◽  
Morgan Darrow ◽  
Richard J Bold ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fluorescence Lifetime ◽  
Automated Detection ◽  
Fluorescence Lifetime Imaging ◽  
Lifetime Imaging

scholarly journals Metabolic Changes in Maternal and Cord Blood in One Case of Pregnancy-Associated Breast Cancer Seen by Fluorescence Lifetime Imaging Microscopy

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1494
Author(s):  
Li Zhou ◽  
Yawei Kong ◽  
Junxin Wu ◽  
Xingzhi Li ◽  
Yiyan Fei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cord Blood ◽  
Fluorescence Lifetime ◽  
Nicotinamide Adenine Dinucleotide Phosphate ◽  
Potential Method ◽  
Metabolic Changes ◽  
Diagnostic Methods ◽  
Fluorescence Lifetime Imaging Microscopy ◽  
Fluorescence Lifetime Imaging ◽  
Lifetime Imaging

Pregnancy-associated breast cancer (PABC) is a rare disease, which is frequently diagnosed at an advanced stage due to limitations in current diagnostic methods. In this study, fluorescence lifetime imaging microscopy (FLIM) was used to study the metabolic changes by measuring maternal blood and umbilical cord blood via the autofluorescence of coenzymes, reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H), and flavin adenine dinucleotide (FAD). The NAD(P)H data showed that a PABC case had significant differences compared with normal cases, which may indicate increased glycolysis. The FAD data showed that both maternal and cord blood of PABC had shorter mean lifetimes and higher bound-FAD ratios. The significant differences suggested that FLIM testing of blood samples may be a potential method to assist in PABC non-radiative screening.

Fluorescence lifetime imaging of unstained tissues: early results in human breast cancer

2003 ◽  
Vol 199 (3) ◽  
pp. 309-317 ◽  
Author(s):  
Paul J Tadrous ◽  
Jan Siegel ◽  
Paul MW French ◽  
Sami Shousha ◽  
El-Nasir Lalani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fluorescence Lifetime ◽  
Human Breast Cancer ◽  
Fluorescence Lifetime Imaging ◽  
Human Breast ◽  
Lifetime Imaging ◽  
Early Results

Metabolic Mapping of MCF10A Human Breast Cells via Multiphoton Fluorescence Lifetime Imaging of the Coenzyme NADH

2005 ◽  
Vol 65 (19) ◽  
pp. 8766-8773 ◽  
Author(s):  
Damian K. Bird ◽  
Long Yan ◽  
Kristin M. Vrotsos ◽  
Kevin W. Eliceiri ◽  
Emily M. Vaughan ◽  
...  
Keyword(s):  
Fluorescence Lifetime ◽  
Fluorescence Lifetime Imaging ◽  
Human Breast ◽  
Metabolic Mapping ◽  
Lifetime Imaging ◽  
Breast Cells
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