Evaluation of Fibroblast Activation Protein-Alpha (FAP) as a Diagnostic Marker and Therapeutic Target in Prostate Cancer

2007 ◽  
Author(s):  
Nathaniel Brennen
Keyword(s):  
Prostate Cancer ◽  
Therapeutic Target ◽  
Diagnostic Marker ◽  
Fibroblast Activation Protein ◽  
Fibroblast Activation ◽  
Fibroblast Activation Protein Alpha

An improved production and purification protocol for recombinant soluble human fibroblast activation protein alpha

2021 ◽  
Vol 181 ◽  
pp. 105833
Author(s):  
Cecy R. Xi ◽  
Arianna Di Fazio ◽  
Naveed Ahmed Nadvi ◽  
Michelle Sui Wen Xiang ◽  
Hui Emma Zhang ◽  
...  
Keyword(s):  
Human Fibroblast ◽  
Fibroblast Activation Protein ◽  
Fibroblast Activation ◽  
Fibroblast Activation Protein Alpha ◽  
Purification Protocol

Somatostatin receptor subtype 1 as a potential diagnostic marker and therapeutic target in prostate cancer

The Prostate ◽  
2017 ◽  
Vol 77 (15) ◽  
pp. 1499-1511 ◽  
Author(s):  
Sergio Pedraza-Arévalo ◽  
Daniel Hormaechea-Agulla ◽  
Enrique Gómez-Gómez ◽  
María J. Requena ◽  
Luke A. Selth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Therapeutic Target ◽  
Diagnostic Marker ◽  
Somatostatin Receptor ◽  
Receptor Subtype

scholarly journals Overcoming stromal barriers to immuno-oncological responses via fibroblast activation protein-targeted therapy

Immunotherapy ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 155-175
Author(s):  
W Nathaniel Brennen ◽  
Daniel L J Thorek ◽  
Wen Jiang ◽  
Timothy E Krueger ◽  
Lizamma Antony ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Targeted Therapy ◽  
Immune Suppression ◽  
Feedback Loop ◽  
Wound Repair ◽  
Repair Process ◽  
Fibroblast Activation Protein ◽  
Primary Data ◽  
Positive Feedback Loop ◽  
Fibroblast Activation

The tumor microenvironment contributes to disease progression through multiple mechanisms, including immune suppression mediated in part by fibroblast activation protein (FAP)-expressing cells. Herein, a review of FAP biology is presented, supplemented with primary data. This includes FAP expression in prostate cancer and activation of latent reservoirs of TGF-β and VEGF to produce a positive feedback loop. This collectively suggests a normal wound repair process subverted during cancer pathophysiology. There has been immense interest in targeting FAP for diagnostic, monitoring and therapeutic purposes. Until recently, this development has outpaced an understanding of the biology; impeding optimal translation into the clinic. A summary of these applications is provided with an emphasis on eliminating tumor-infiltrating FAP-positive cells to overcome stromal barriers to immuno-oncological responses.

Role of Alpha-Smooth Muscle Actin and Fibroblast Activation Protein Alpha in Ovarian Neoplasms

2018 ◽  
Vol 83 (4) ◽  
pp. 381-387 ◽  
Author(s):  
Ana Carolinne da Silva ◽  
Millena Prata Jammal ◽  
Renata Margarida Etchebehere ◽  
Eddie Fernando Candido Murta ◽  
Rosekeila Simões Nomelini
Keyword(s):  
Smooth Muscle ◽  
Ovarian Neoplasms ◽  
Smooth Muscle Actin ◽  
Fibroblast Activation Protein ◽  
Muscle Actin ◽  
Alpha Smooth Muscle Actin ◽  
Fibroblast Activation ◽  
Fibroblast Activation Protein Alpha
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