CHEK2*1100DELC Variant and Breast Cancer Risk

2006 ◽  
Author(s):  
Habibul Ahsan
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Chek2 1100Delc

Excess breast cancer risk in first degree relatives of CHEK2∗1100delC positive familial breast cancer cases

2013 ◽  
Vol 49 (8) ◽  
pp. 1993-1999 ◽  
Author(s):  
Muriel A. Adank ◽  
Senno Verhoef ◽  
Rogier A. Oldenburg ◽  
Marjanka K. Schmidt ◽  
Maartje J. Hooning ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Familial Breast Cancer ◽  
Chek2 1100Delc ◽  
First Degree Relatives

scholarly journals Genetic modifiers of CHEK2*1100delC-associated breast cancer risk

2016 ◽  
Vol 19 (5) ◽  
pp. 599-603 ◽  
Author(s):  
Taru A. Muranen ◽  
◽  
Dario Greco ◽  
Carl Blomqvist ◽  
Kristiina Aittomäki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Genetic Modifiers ◽  
Chek2 1100Delc

scholarly journals CHEK2*1100delC and male breast cancer risk in Israel

2003 ◽  
Vol 108 (3) ◽  
pp. 479-480 ◽  
Author(s):  
Tal Ohayon ◽  
Inbar Gal ◽  
Ruth Gershoni Baruch ◽  
Csilla Szabo ◽  
Eitan Friedman
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Male Breast Cancer ◽  
Male Breast ◽  
Chek2 1100Delc

scholarly journals Age- and Tumor Subtype–Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers

2016 ◽  
Vol 34 (23) ◽  
pp. 2750-2760 ◽  
Author(s):  
Marjanka K. Schmidt ◽  
Frans Hogervorst ◽  
Richard van Hien ◽  
Sten Cornelissen ◽  
Annegien Broeks ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Risk Prediction ◽  
Invasive Breast Cancer ◽  
Taqman Assay ◽  
Tumor Subtype ◽  
Chek2 1100Delc ◽  
Risk Estimates ◽  
Er Positive

Purpose CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its usefulness in breast cancer risk prediction. We aimed to generate tumor subtype- and age-specific risk estimates by using data from the Breast Cancer Association Consortium, including 44,777 patients with breast cancer and 42,997 controls from 33 studies genotyped for CHEK2*1100delC. Patients and Methods CHEK2*1100delC genotyping was mostly done by a custom Taqman assay. Breast cancer odds ratios (ORs) for CHEK2*1100delC carriers versus noncarriers were estimated by using logistic regression and adjusted for study (categorical) and age. Main analyses included patients with invasive breast cancer from population- and hospital-based studies. Results Proportions of heterozygous CHEK2*1100delC carriers in controls, in patients with breast cancer from population- and hospital-based studies, and in patients with breast cancer from familial- and clinical genetics center–based studies were 0.5%, 1.3%, and 3.0%, respectively. The estimated OR for invasive breast cancer was 2.26 (95%CI, 1.90 to 2.69; P = 2.3 × 10−20). The OR was higher for estrogen receptor (ER)–positive disease (2.55 [95%CI, 2.10 to 3.10; P = 4.9 × 10−21]) than it was for ER-negative disease (1.32 [95%CI, 0.93 to 1.88; P = .12]; P interaction = 9.9 × 10−4). The OR significantly declined with attained age for breast cancer overall (P = .001) and for ER-positive tumors (P = .001). Estimated cumulative risks for development of ER-positive and ER-negative tumors by age 80 in CHEK2*1100delC carriers were 20% and 3%, respectively, compared with 9% and 2%, respectively, in the general population of the United Kingdom. Conclusion These CHEK2*1100delC breast cancer risk estimates provide a basis for incorporating CHEK2*1100delC into breast cancer risk prediction models and into guidelines for intensified screening and follow-up.

CHEK2*1100delC homozygosity is associated with a high breast cancer risk in women

2011 ◽  
Vol 48 (12) ◽  
pp. 860-863 ◽  
Author(s):  
M. A. Adank ◽  
M. A. Jonker ◽  
I. Kluijt ◽  
S. E. van Mil ◽  
R. A. Oldenburg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Chek2 1100Delc ◽  
High Breast Cancer Risk
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