Impact of C-neu/erbB2 on Estrogen and Estrogen Receptor Alpha-Dependent Proliferation of Mammary Ductal Epithelial Cells

2003 ◽  
Author(s):  
Gopalan Shyamala
Keyword(s):  
Estrogen Receptor ◽  
Epithelial Cells ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha

scholarly journals Mammary Fat Can Adjust Prolactin Effect on Mammary Epithelial Cells via Leptin and Estrogen

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Yonatan Feuermann ◽  
Sameer J. Mabjeesh ◽  
Avi Shamay
Keyword(s):  
Estrogen Receptor ◽  
Epithelial Cells ◽  
Estrogen Receptor Alpha ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Fat Pad ◽  
Paracrine Factors ◽  
Receptor Alpha ◽  
Mammary Fat Pad ◽  
Aromatase Mrna

Leptin, like estrogen, is one of the endo/paracrine factors, which are synthesized in and secreted from mature adipocytes. The roles of the mammary fat pad and mammary adipocytes in the initiation of lactation are not clear. In this study, we showed that combination of prolactin, leptin and estrogen elevated the expression of the milk protein beta-lactoglobulin. We also showed that after prolactin stimulate the secretion of leptin from the mammary fat, leptin upregulated the expression of estrogen receptor alpha in the mammary epithelial cells. Also, prolactin affected aromatase mRNA expression in the bovine mammary fat and we demonstrated that leptin and prolactin can affect cholesterol secretion from explants in culture to the medium. Therefore, we suggest that prolactin initiates estrogen expression (as represented by aromatase mRNA) in the mammary fat pad, whereas leptin stimulates estrogen receptor alpha expression in the mammary epithelial cells. We hypothesize that leptin and estrogen, secreted from the mammary fat regulate lactation after stimulation of prolactin.

Effects of phosphorylated estrogen receptor alpha on apoptosis in human endometrial epithelial cells

2019 ◽  
Vol 95 (2) ◽  
pp. 240-250
Author(s):  
Shunsuke Uchida ◽  
Mierxiati Saimi ◽  
Zhong-Lian Li ◽  
Hidenobu Miyaso ◽  
Kenta Nagahori ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Epithelial Cells ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Endometrial Epithelial Cells

scholarly journals Spontaneous Basaloid Adenomas of the Mammary Gland in Four Dogs: Clinicopathologic and Immunohistochemical Features

2002 ◽  
Vol 39 (6) ◽  
pp. 739-743 ◽  
Author(s):  
J. Martín de las Mulas ◽  
J. Ordás ◽  
M. Y. Millán ◽  
A. Espinosa de los Monteros ◽  
C. Reymundo
Keyword(s):  
Estrogen Receptor ◽  
Mammary Gland ◽  
Epithelial Cells ◽  
Tumor Cells ◽  
Basal Cell ◽  
Estrogen Receptor Alpha ◽  
Progesterone Receptors ◽  
Receptor Alpha ◽  
Contraceptive Steroids

Spontaneous basaloid adenomas occurred in four out of 354 dogs with mammary tumors. Affected dogs were pure-bred, intact females between 6 and 8 years of age. Three dogs were nuliparous, two had pseudopregnancies, and none had received contraceptive steroids. The tumors were multiple (three cases) or unique, less than 1 cm in diameter, well delineated, and composed of uniform cords and clusters of monomorphic epithelial cells with focal signs of squamous or glandular differentiation. A basal cell immunophenotype (cytokeratins 5 and 14 positive) without either glandular epithelial (cytokeratins 8, 18, and 19 negative) or myoepithelial (calponin negative) differentiation was observed in the majority of tumor cells. No recurrence or metastasis was recorded after follow-up periods between 3 and 24 months. In spite of the hormone-dependent nature of this tumor in female Beagles given experimental contraceptive steroids, spontaneous basaloid adenomas lacked estrogen receptor alpha and progesterone receptors.

Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells

2006 ◽  
Vol 99 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Abde M. Abukhdeir ◽  
Brian G. Blair ◽  
Keith Brenner ◽  
Bedri Karakas ◽  
Hiroyuki Konishi ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Epithelial Cells ◽  
Estrogen Receptor Alpha ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Receptor Alpha ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial
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