scholarly journals Modelling estrogen receptor alpha-positive breast cancer by transformation of normal human mammary epithelial cells

2008 ◽  
Vol 10 (S2) ◽  
Author(s):  
X Schmidt ◽  
S Duss ◽  
RD Iggo
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Epithelial Cells ◽  
Estrogen Receptor Alpha ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Receptor Alpha ◽  
Human Mammary Epithelial ◽  
Normal Human ◽  
Positive Breast Cancer

Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells

2006 ◽  
Vol 99 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Abde M. Abukhdeir ◽  
Brian G. Blair ◽  
Keith Brenner ◽  
Bedri Karakas ◽  
Hiroyuki Konishi ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Epithelial Cells ◽  
Estrogen Receptor Alpha ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Receptor Alpha ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial

scholarly journals Mammary Fat Can Adjust Prolactin Effect on Mammary Epithelial Cells via Leptin and Estrogen

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Yonatan Feuermann ◽  
Sameer J. Mabjeesh ◽  
Avi Shamay
Keyword(s):  
Estrogen Receptor ◽  
Epithelial Cells ◽  
Estrogen Receptor Alpha ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Fat Pad ◽  
Paracrine Factors ◽  
Receptor Alpha ◽  
Mammary Fat Pad ◽  
Aromatase Mrna

Leptin, like estrogen, is one of the endo/paracrine factors, which are synthesized in and secreted from mature adipocytes. The roles of the mammary fat pad and mammary adipocytes in the initiation of lactation are not clear. In this study, we showed that combination of prolactin, leptin and estrogen elevated the expression of the milk protein beta-lactoglobulin. We also showed that after prolactin stimulate the secretion of leptin from the mammary fat, leptin upregulated the expression of estrogen receptor alpha in the mammary epithelial cells. Also, prolactin affected aromatase mRNA expression in the bovine mammary fat and we demonstrated that leptin and prolactin can affect cholesterol secretion from explants in culture to the medium. Therefore, we suggest that prolactin initiates estrogen expression (as represented by aromatase mRNA) in the mammary fat pad, whereas leptin stimulates estrogen receptor alpha expression in the mammary epithelial cells. We hypothesize that leptin and estrogen, secreted from the mammary fat regulate lactation after stimulation of prolactin.

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