Biochemical Markers for Exposure to Low Doses of Organophosphorus Insecticides

2003 ◽  
Author(s):  
Oksana Lockridge
Keyword(s):  
Biochemical Markers ◽  
Low Doses ◽  
Organophosphorus Insecticides

scholarly journals EARLY PREDICTION OF PREECLAMPSIA ÎN PREGNANCY

2017 ◽  
Vol 64 (1) ◽  
pp. 34-37
Author(s):  
Oana Mihaela Iordache ◽  
◽  
Liliana Neştianu ◽  
George Erick Neştianu ◽  
◽  
...  
Keyword(s):  
Biochemical Markers ◽  
Perinatal Outcome ◽  
Early Prediction ◽  
Low Doses ◽  
Perinatal Morbidity ◽  
Maternal Risk Factors ◽  
Major Health Problem ◽  
Major Health ◽  
Maternal Risk ◽  
In Pregnancy

Preeclampsia is a major health problem because it determines higher incidence in maternal and perinatal morbidity. Early prediction of preeclampsia in pregnancy can improve both the maternal and perinatal outcome by ensuring appropriate management. There are multiple algorithms using maternal risk factors, biophysical markers, biochemical markers and they try to predict preeclampsia. Low doses of aspirin can improve the prognostic of preeclampsia.

scholarly journals Long Term Alteration of Immune Functions Following Low Level Exposure to Sarin in Rats

2000 ◽  
Vol 43 (3) ◽  
pp. 91-94 ◽  
Author(s):  
Jiří Kassa ◽  
Zuzana Kročová ◽  
Josef Vachek
Keyword(s):  
Bactericidal Activity ◽  
Inhalation Exposure ◽  
Nerve Agent ◽  
Peritoneal Macrophages ◽  
Low Doses ◽  
Immune Functions ◽  
Organophosphorus Insecticides ◽  
Spleen Cells

1. Long term alteration of immune functions caused by low doses of nerve agent sarin were studied in rats exposed to sarin by inhalation. The alteration of immune functions by sarin was monitored by using two methods (the evaluation of in vitro spontaneous as well as stimulated proliferation of spleen cells and in vitro bactericidal activity of peritoneal macrophages) at 3, 6 and 12 months following sarin exposure. 2. The results indicate that not only symptomatic but also asymptomatic dose of sarin is able to alter some immune functions at six and twelve months following exposure to sarin. 3. Thus, not only organophosphorus insecticides but also nerve agents such as sarin can be potentially immunotoxic even at very low doses that do not cause clinically manifested intoxication following the inhalation exposure. The ability of sarin at low doses to alter immune functions seems to be really long term (up to 12 months following the exposure).

The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

1982 ◽  
Vol 40 ◽  
pp. 252-253
Author(s):  
D.E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Dose ◽  
B Cell ◽  
Cell Survival ◽  
Spermatogonial Stem Cell ◽  
Low Doses ◽  
Particle Irradiation ◽  
Stem Cell Survival ◽  
Irradiation Injury ◽  
Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

Potentiation of bromotrichloromethane hepatotoxicity in male rats exposed to 10 ppm dietary chlordecone: Electron Microscopic and biochemical study

1990 ◽  
Vol 48 (3) ◽  
pp. 284-285
Author(s):  
O. M. Faroon ◽  
R. W. Henry ◽  
M. G. Soni ◽  
H. M. Mehendale
Keyword(s):  
Free Radical ◽  
Biochemical Study ◽  
Prior Exposure ◽  
Male Rats ◽  
Cellular Injury ◽  
Low Doses ◽  
Mixed Function Oxidase ◽  
Electron Microscopic ◽  
Potent Inducer ◽  
Cellular Energy

Previous work has shown that mirex undergoes photolytic dechlorination to chlordecone (CD) (KeponeR) in the environment. Much work has shown that prior exposure to nontoxic levels of CD causes potentiation of hepatotoxicity and lethality of CCl4, BrCCl3 and other halomethane compounds. Potentiation of bromotrichloromethane hepatotoxicity has been associated with compounds that stimulate the activity of hepatic mixed-function oxidase (MFO). An increase in the metabolism of halomethane by the MFO to a free radical initiates peroxidative decomposition of membranal lipids ending in massive cellular injury. However, not all MFO inducers potentiate BrCCl3 hepatotoxicity. Potentiation by much larger doses of phenobarbital is minimal and th at by a more potent inducer of MFO, mirex, is negligible at low doses. We suggest that the CD and bromotrichloromethane interaction results in a depletion of cellular energy and thereby reducing the cellular ability to undergo mitosis.

Low doses of pamidronate to treat osteopenia in children with severe cerebral palsy: a pilot study

2006 ◽  
Vol 48 (09) ◽  
pp. 709 ◽  
Author(s):  
Horacio Plotkin ◽  
Susan Coughlin ◽  
Rose Kreikemeier ◽  
Kathryn Heldt ◽  
Matias Bruzoni ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Pilot Study ◽  
Low Doses
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