Optimized Hyperthermia Treatment of Prostate Cancer Using a Novel Intracavitary Ultrasound Array

2003 ◽  
Author(s):  
Nadine Smith ◽  
Lewis E. Harpster ◽  
Robert M. Keolian ◽  
Victor Sparrow ◽  
Andrew Webb
Keyword(s):  
Prostate Cancer ◽  
Hyperthermia Treatment

Comparison of low-temperature-sensitive liposome encapsulated docetaxel and doxorubicin in a murine model of prostate cancer.

2011 ◽  
Vol 29 (7_suppl) ◽  
pp. 31-31 ◽  
Author(s):  
S. Chokshi ◽  
A. Ranjan ◽  
C. J. Benjamin ◽  
P. H. Chung ◽  
A. Rastinehad ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Low Temperature ◽  
Tumor Growth ◽  
Temperature Sensitive ◽  
Complete Regression ◽  
Hyperthermia Treatment ◽  
Treatment Volume ◽  
Survival Studies ◽  
The Right ◽  
To Receive

31 Background: Low-temperature-sensitive liposomes (LTSLs) release their encapsulated drug into targeted tissue when activated by a source of hyperthermia. The efficacy of an LTSL formulation of docetaxel (DOC) or doxorubicin (DOX) was compared against prostate cancer in a xenograft mouse model. Methods: Under an approved IACUC protocol, Luciferase transfected human prostate PC-3M-luciferase cells were inoculated (3x106 cells) subcutaneously in the right hind leg of 8 wk old female athymic nude mice. When tumors reached a volume of 200–300 mm3, mice were randomized to receive one intravenous injection of saline, Stealth liposomal DOX (5 mg/kg), LTSL DOX (5 mg/kg), or LTSL DOC (15 mg/kg), with or without hyperthermia treatment (LTSL DOX and LTSL DOC were supplied by Celsion Corp., Columbia MD). Mice undergoing hyperthermia treatment were anesthetized and stabilized in a holder that allowed for only the leg with tumor to be heated to 41–42°C that triggered LTSL drug release. Mice were monitored daily for tumor volume and body weight. Study end-points included growth of tumor to 5x the initial treatment volume or monitoring of survival for 60 days. Results: The LTSL DOC delayed tumor growth longer (> 14 days) than DOX (0 day) and LTSL DOX (1 day) with hyperthermia (P<0.05). Mice treated with LTSL DOC and hyperthermia survived longest (60 days) compared to all other mice (range 6–8 days, P<0.05). LTSL in the setting of hyperthermia demonstrated complete regression of tumor in 57% of mice. Conclusions: LTSL DOC with hyperthermia delayed tumor growth more than all other treatments. Survival studies suggest LTSL DOC is a more effective temperature sensitive delivery system against PC-3M prostate tumors. No significant financial relationships to disclose.

Folic acid on iron oxide nanoparticles: platform with high potential for simultaneous targeting, MRI detection and hyperthermia treatment of lymph node metastases of prostate cancer

2017 ◽  
Vol 46 (37) ◽  
pp. 12692-12704 ◽  
Author(s):  
Debora Bonvin ◽  
Jessica A. M. Bastiaansen ◽  
Matthias Stuber ◽  
Heinrich Hofmann ◽  
Marijana Mionić Ebersold
Keyword(s):  
Prostate Cancer ◽  
Folic Acid ◽  
Lymph Node ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Lymph Node Metastases ◽  
High Potential ◽  
Oxide Nanoparticles ◽  
Hyperthermia Treatment ◽  
Node Metastases

Folic acid directly bound to the surface of iron oxide nanoparticles with simultaneously high targeting, MRI relaxivity and heating efficacy.

Optimized hyperthermia treatment of prostate cancer using a novel intravavitary ultrasound array

2003 ◽  
Vol 114 (4) ◽  
pp. 2347-2347
Author(s):  
Osama M. Al‐Bataineh ◽  
Nadine B. Smith ◽  
Robert M. Keolian ◽  
Victor W. Sparrow ◽  
Lewis E. Harpster
Keyword(s):  
Prostate Cancer ◽  
Hyperthermia Treatment

Sigmoidoscopic findings following radiation for prostate cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A284-A284
Author(s):  
T BOLIN ◽  
A KNEEBONE ◽  
T LARSSON
Keyword(s):  
Prostate Cancer

1625: Neuroligin 4 ISOFORM Y: A Novel Marker for Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 538-539
Author(s):  
Joseph F. Pazona ◽  
C. Shad Thaxton ◽  
Neema Navai ◽  
Brian T. Helfand ◽  
Lee C. Zhao ◽  
...  
Keyword(s):  
Prostate Cancer

232: Natural History of Treated Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 77-78
Author(s):  
Christopher R. Porter ◽  
Jochen Walz ◽  
Andrea Gallina ◽  
Claudio Jeldres ◽  
Koichi Kodama ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Natural History ◽  
Biochemical Recurrence ◽  
History Of
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