Folic acid on iron oxide nanoparticles: platform with high potential for simultaneous targeting, MRI detection and hyperthermia treatment of lymph node metastases of prostate cancer

2017 ◽  
Vol 46 (37) ◽  
pp. 12692-12704 ◽  
Author(s):  
Debora Bonvin ◽  
Jessica A. M. Bastiaansen ◽  
Matthias Stuber ◽  
Heinrich Hofmann ◽  
Marijana Mionić Ebersold
Keyword(s):  
Prostate Cancer ◽  
Folic Acid ◽  
Lymph Node ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Lymph Node Metastases ◽  
High Potential ◽  
Oxide Nanoparticles ◽  
Hyperthermia Treatment ◽  
Node Metastases

Folic acid directly bound to the surface of iron oxide nanoparticles with simultaneously high targeting, MRI relaxivity and heating efficacy.

scholarly journals Magnetic Marking and Intraoperative Detection of Primary Draining Lymph Nodes in High-Risk Prostate Cancer Using Superparamagnetic Iron Oxide Nanoparticles: Additional Diagnostic Value?

2017 ◽  
Author(s):  
Alexander Winter ◽  
Svenja Engels ◽  
Lena Reinhardt ◽  
Clara Wasylow ◽  
Holger Gerullis ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
High Risk ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Superparamagnetic Iron Oxide ◽  
Diagnostic Value ◽  
Sentinel Lymph Nodes ◽  
Oxide Nanoparticles ◽  
Node Metastases

Sentinel lymph node dissection (sLND) using a magnetometer and superparamagnetic iron oxide nanoparticles (SPIONs) as a tracer was successfully applied in prostate cancer (PCa). Radioisotope-guided sLND combined with extended pelvic LND (ePLND) achieved better node removal, increasing the number of affected nodes or the detection of sentinel lymph nodes outside the established ePLND template. We determined the diagnostic value of additional magnetometer-guided sLND after intraprostatic SPION-injection in high-risk PCa. This retrospective study included 104 high-risk PCa patients (PSA >20 ng/ml and/or Gleason score ≥8 and/or cT2c) from a prospective cohort who underwent radical prostatectomy with magnetometer-guided sLND and ePLND. The diagnostic accuracy of sLND was assessed using ePLND as a reference standard. Lymph node metastases were found in 61 of 104 patients (58.7%). sLND had a 100% diagnostic rate, 96.6% sensitivity, 95.6% specificity, 96.6% positive predictive value, 95.6% negative predictive value, 3.4% false negative rate, and 4.4% false positive rate (detecting lymph node metastases outside the ePLND template). These findings demonstrate the high sensitivity and additional diagnostic value of magnetometer-guided sLND, exceeding that of ePLND through the individualized extension of PLND or the detection of sentinel lymph nodes / lymph node metastases outside the established node template in high-risk PCa.

Shaping and Cellular Uptake of Folic Acid Coated Gold and Magnetite Nanoparticles

2019 ◽  
Vol 9 (2) ◽  
pp. 166-172
Author(s):  
Ahmed A.G. El-Shahawy ◽  
Gamal Elghnam ◽  
Alsayed A.M. Alsherbini
Keyword(s):  
Folic Acid ◽  
Iron Oxide ◽  
Tumor Cells ◽  
Iron Oxide Nanoparticles ◽  
Individual Cell ◽  
Oxide Nanoparticles ◽  
Cellular Compartment ◽  
Specific Tumor ◽  
Uv Visible

Background:Gold and Iron Oxide nanoparticles NPs play as nanocarriers for a specific drug delivery and contrast agents. Intercellular uptake of these nanoparticles and targeting to individual cell and sub-cellular compartment is essential.Objective:The aim of the current study is to evaluate the intracellular uptake of these NPs to specific tumor cells in vitro conjugated with folic acid with a goal of enhancing the efficiency of specific targeting to tumor cells.Methods:We synthesized the nanoparticles by a chemical method and characterized by UV-Visible, FTIR, XRD, and TEM.Results & Conclusion:The results revealed the conjugation of Gold and Iron Oxide nanoparticles with folic acid increased the intercellular uptake with high percent compared to non- conjugated nanoparticles.

scholarly journals Direct comparison of choline PET/CT and MRI in the diagnosis of lymph node metastases in patients with prostate cancer

Medicine ◽  
2018 ◽  
Vol 97 (50) ◽  
pp. e13344 ◽  
Author(s):  
Shi-ming Huang ◽  
Liang Yin ◽  
Jian-lan Yue ◽  
Yan-feng Li ◽  
Yang Yang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Choline Pet ◽  
Pet Ct ◽  
Node Metastases ◽  
Ct And Mri

Androgen receptor status of lymph node metastases from prostate cancer

The Prostate ◽  
1996 ◽  
Vol 28 (2) ◽  
pp. 129-135 ◽  
Author(s):  
Alfred Hobisch ◽  
Zoran Culig ◽  
Christian Radmayr ◽  
Georg Bartsch ◽  
Helmut Klocker ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Androgen Receptor ◽  
Lymph Node Metastases ◽  
Receptor Status ◽  
Node Metastases
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